Celermajer DS, Chow CK, Marijon E, Anstey NM, Woo KS: Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J Am Coll Cardiol 2012, 60: 1207–1216. 10.1016/j.jacc.2012.03.074
Sanganalmath SK, Bolli R: Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res 2013,113(6):810–834. 10.1161/CIRCRESAHA.113.300219
Steinhauser ML, Lee RT: Regeneration of the heart. EMBO Mol Med 2011, 3: 701–712. 10.1002/emmm.201100175
Mingliang R, Bo Z, Zhengguo W: Stem cells for cardiac repair: status, mechanisms, and new strategies. Stem Cells Int 2011, 2011: 310928.
Duran JM, Makarewich CA, Sharp TE, Starosta T, Zhu F, Hoffman NE, Chiba Y, Madesh M, Berretta RM, Kubo H, Houser SR: Bone-Derived Stem Cells Repair the Heart after Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms. Circ Res 2013,113(5):539–552. 10.1161/CIRCRESAHA.113.301202
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J: Evidence for cardiomyocyte renewal in humans. Science 2009, 324: 98–102. 10.1126/science.1164680
Kajstura J, Gurusamy N, Ogorek B, Goichberg P, Clavo-Rondon C, Hosoda T, D'Amario D, Bardelli S, Beltrami AP, Cesselli D, Bussani R, del Monte F, Quaini F, Rota M, Beltrami CA, Buchholz BA, Leri A, Anversa P: Myocyte turnover in the aging human heart. Circ Res 2010, 107: 1374–1386. 10.1161/CIRCRESAHA.110.231498
Barile L, Messina E, Giacomello A, Marban E: Endogenous cardiac stem cells. Prog Cardiovasc Dis 2007, 50: 31–48. 10.1016/j.pcad.2007.03.005
Hou J, Wang L, Jiang J, Zhou C, Guo T, Zheng S, Wang T: Cardiac Stem Cells and their Roles in Myocardial Infarction. Stem Cell Rev 2013, 9: 326–338. 10.1007/s12015-012-9421-4
Hosoda T: C-kit-positive cardiac stem cells and myocardial regeneration. Am J Cardiovasc Dis 2012, 2: 58–67.
Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114: 763–776. 10.1016/S0092-8674(03)00687-1
Tallini YN, Greene KS, Craven M, Spealman A, Breitbach M, Smith J, Fisher PJ, Steffey M, Hesse M, Doran RM, Woods A, Singh B, Yen A, Fleischmann BK, Kotlikoff MI: c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci U S A 2009, 106: 1808–1813. 10.1073/pnas.0808920106
Hatzistergos KE, Quevedo H, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, Mazhari R, Boyle AJ, Zambrano JP, Rodriguez JE, Dulce R, Pattany PM, Valdes D, Revilla C, Heldman AW, McNiece I, Hare JM: Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 2010, 107: 913–922. 10.1161/CIRCRESAHA.110.222703
Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD: Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002, 105: 93–98. 10.1161/hc0102.101442
Fuh E, Brinton TJ: Bone marrow stem cells for the treatment of ischemic heart disease: a clinical trial review. J Cardiovasc Transl Res 2009, 2: 202–218. 10.1007/s12265-009-9095-8
Yoon YS, Wecker A, Heyd L, Park JS, Tkebuchava T, Kusano K, Hanley A, Scadova H, Qin G, Cha DH, Johnson KL, Aikawa R, Asahara T, Losordo DW: Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005, 115: 326–338. 10.1172/JCI200522326
Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P: Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A 2007, 104: 17783–17788. 10.1073/pnas.0706406104
Hwang JH, Shim SS, Seok OS, Lee HY, Woo SK, Kim BH, Song HR, Lee JK, Park YK: Comparison of cytokine expression in mesenchymal stem cells from human placenta, cord blood, and bone marrow. J Korean Med Sci 2009, 24: 547–554. 10.3346/jkms.2009.24.4.547
Murry CE, Kay MA, Bartosek T, Hauschka SD, Schwartz SM: Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD. J Clin Invest 1996, 98: 2209–2217. 10.1172/JCI119030
Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126: 663–676. 10.1016/j.cell.2006.07.024
Gnecchi M, Zhang Z, Ni A, Dzau VJ: Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008, 103: 1204–1219. 10.1161/CIRCRESAHA.108.176826
Maltais S, Tremblay JP, Perrault LP, Ly HQ: The paracrine effect: pivotal mechanism in cell-based cardiac repair. J Cardiovasc Transl Res 2010, 3: 652–662. 10.1007/s12265-010-9198-2
Aggarwal S, Pittenger MF: Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105: 1815–1822. 10.1182/blood-2004-04-1559
Chablais F, Jazwinska A: The regenerative capacity of the zebrafish heart is dependent on TGFbeta signaling. Development 2012, 139: 1921–1930. 10.1242/dev.078543
Abarbanell AM, Coffey AC, Fehrenbacher JW, Beckman DJ, Herrmann JL, Weil B, Meldrum DR: Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart. Ann Thorac Surg 2009, 88: 1036–1043. 10.1016/j.athoracsur.2009.02.093
Bujak M, Frangogiannis NG: The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 2007, 74: 184–195. 10.1016/j.cardiores.2006.10.002
Zhao L, Hantash BM: TGF-beta1 regulates differentiation of bone marrow mesenchymal stem cells. Vitam Horm 2011, 87: 127–141.
Ng F, Boucher S, Koh S, Sastry KS, Chase L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS, Tanavde V: PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood 2008, 112: 295–307. 10.1182/blood-2007-07-103697
Park JS, Chu JS, Tsou AD, Diop R, Tang Z, Wang A, Li S: The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-beta. Biomaterials 2011, 32: 3921–3930. 10.1016/j.biomaterials.2011.02.019
Rouhi L, Kajbafzadeh AM, Modaresi M, Shariati M, Hamrahi D: Autologous serum enhances cardiomyocyte differentiation of rat bone marrow mesenchymal stem cells in the presence of transforming growth factor-beta1 (TGF-beta1). In Vitro Cell Dev Biol Anim 2013, 49: 287–294. 10.1007/s11626-013-9597-1
Grotzinger J, Kurapkat G, Wollmer A, Kalai M, Rose-John S: The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes. Proteins 1997, 27: 96–109. 10.1002/(SICI)1097-0134(199701)27:1<96::AID-PROT10>3.0.CO;2-D
Hibi M, Nakajima K, Hirano T: IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med (Berl) 1996, 74: 1–12. 10.1007/BF00202068
Hou T, Tieu BC, Ray S, Recinos Iii A, Cui R, Tilton RG, Brasier AR: Roles of IL-6-gp130 signaling in vascular inflammation. Curr Cardiol Rev 2008, 4: 179–192. 10.2174/157340308785160570
Pachowka M, Zegarska J, Ciecierski R, Korczak-Kowalska G: The role of IL-6 during the late phase of liver regeneration. Ann Transplant 2008, 13: 15–19.
Toth KG, McKay BR, De Lisio M, Little JP, Tarnopolsky MA, Parise G: IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage. PLoS One 2011, 6: e17392. 10.1371/journal.pone.0017392
Zhang C, Li Y, Wu Y, Wang L, Wang X, Du J: Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration. J Biol Chem 2013, 288: 1489–1499. 10.1074/jbc.M112.419788
Freed DH, Cunnington RH, Dangerfield AL, Sutton JS, Dixon IM: Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc Res 2005, 65: 782–792. 10.1016/j.cardiores.2004.11.026
Jougasaki M: Cardiotrophin-1 in cardiovascular regulation. Adv Clin Chem 2010, 52: 41–76.
Apostolakis S, Papadakis EG, Krambovitis E, Spandidos DA: Chemokines in vascular pathology (review). Int J Mol Med 2006, 17: 691–701.
Yu J, Li M, Qu Z, Yan D, Li D, Ruan Q: SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt. J Cardiovasc Pharmacol 2010, 55: 496–505.
Li N, Lu X, Zhao X, Xiang FL, Xenocostas A, Karmazyn M, Feng Q: Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha. Stem Cells 2009, 27: 961–970. 10.1002/stem.6
Wang Y, Luther K: Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1alpha/CXCR4 signaling pathway. Prog Mol Biol Transl Sci 2012, 111: 265–284.
Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK: Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 2010, 4: 214–222. 10.1016/j.scr.2009.12.003
Boomsma RA, Geenen DL: Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis. PLoS One 2012, 7: e35685. 10.1371/journal.pone.0035685
Razban V, Lotfi AS, Soleimani M, Ahmadi H, Massumi M, Khajeh S, Ghaedi M, Arjmand S, Najavand S, Khoshdel A: HIF-1alpha Overexpression Induces Angiogenesis in Mesenchymal Stem Cells. Biores Open Access 2012, 1: 174–183. 10.1089/biores.2012.9905
Hoenig MR, Bianchi C, Sellke FW: Hypoxia inducible factor-1 alpha, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis. Curr Drug Targets 2008, 9: 422–435. 10.2174/138945008784221215
Przybylski M: A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care 2009, 18: 516–519.
Ramani P, Nash R, Radevsky L, Patel A, Luckett M, Rogers C: VEGF-C, VEGF-D and VEGFR-3 expression in peripheral neuroblastic tumours. Histopathology 2012, 61: 1006–1016. 10.1111/j.1365-2559.2012.04307.x
Stalmans I: Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. Verh K Acad Geneeskd Belg 2005, 67: 229–276.
Mathison M, Gersch RP, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK: In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. J Am Heart Assoc 2012, 1: e005652.
Ye L, Zhang S, Greder L, Dutton J, Keirstead SA, Lepley M, Zhang L, Kaufman D, Zhang J: Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF. PLoS One 2013, 8: e53764. 10.1371/journal.pone.0053764
Gentile C, Muise-Helmericks RC, Drake CJ: VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Dev Biol 2013, 373: 163–175. 10.1016/j.ydbio.2012.10.020
Beenken A, Mohammadi M: The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009, 8: 235–253. 10.1038/nrd2792
Holmes DI, Zachary IC: Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2. Cell Signal 2008, 20: 569–579. 10.1016/j.cellsig.2007.11.009
Murakami M, Simons M: Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol 2008, 15: 215–220. 10.1097/MOH.0b013e3282f97d98
Moya ML, Cheng MH, Huang JJ, Francis-Sedlak ME, Kao SW, Kao SW, Opara EC, Brey EM: The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering. Biomaterials 2010, 31: 2816–2826. 10.1016/j.biomaterials.2009.12.053
Takahashi M, Okubo N, Chosa N, Takahashi N, Ibi M, Kamo M, Mizuki H, Ishisaki A, Kyakumoto S: Fibroblast growth factor-1-induced ERK1/2 signaling reciprocally regulates proliferation and smooth muscle cell differentiation of ligament-derived endothelial progenitor cell-like cells. Int J Mol Med 2012, 29: 357–364.
Kim SW, Lee DW, Yu LH, Zhang HZ, Kim CE, Kim JM, Park TH, Cha KS, Seo SY, Roh MS, Lee KC, Jung JS, Kim MH: Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model. Cardiovasc Res 2012, 95: 495–506. 10.1093/cvr/cvs224
Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V: Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A 2007, 104: 1643–1648. 10.1073/pnas.0610024104
Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, Fan GC: Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells 2009, 27: 3021–3031.
Hahn JY, Cho HJ, Kang HJ, Kim TS, Kim MH, Chung JH, Bae JW, Oh BH, Park YB, Kim HS: Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 2008, 51: 933–943. 10.1016/j.jacc.2007.11.040
Chang MG, Tung L, Sekar RB, Chang CY, Cysyk J, Dong P, Marbán E, Abraham MR: Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model. Circulation 2006, 113: 1832–1841. 10.1161/CIRCULATIONAHA.105.593038
Ly HQ, Nattel S: Stem cells are not proarrhythmic: letting the genie out of the bottle. Circulation 2009, 119: 1824–1831. 10.1161/CIRCULATIONAHA.108.812701
Du YY, Zhou SH, Zhou T, Su H, Pan HW, Du WH, Liu B, Liu QM: Immuno-inflammatory regulation effect of mesenchymal stem cell transplantation in a rat model of myocardial infarction. Cytotherapy 2008, 10: 469–478. 10.1080/14653240802129893
Soleymaninejadian E, Pramanik K, Samadian E: Immunomodulatory properties of mesenchymal stem cells: cytokines and factors. Am J Reprod Immunol 2012, 67: 1–8.