Closing the evidence gap in infectious disease: point-of-care randomization and informed consent

Faden, 2014, Informed consent, comparative effectiveness, and learning health care, N Engl J Med, 370, 766, 10.1056/NEJMhle1313674 Mellanby, 1947, Medical experiments on human beings in concentration camps in Nazi Germany, Br Med J, 1, 148, 10.1136/bmj.1.4490.148 Rockwell, 1964, The Tuskegee Study of Untreated Syphilis; the 30th year of observation, Arch Intern Med, 114, 792, 10.1001/archinte.1964.03860120104011 Kant, 1993 Dreyfuss, 2005, Is it better to consent to an RCT or to care? Muetadeltaepsilonnu alphagammaalphanu (‘nothing in excess’), Intensive Care Med, 31, 345, 10.1007/s00134-004-2493-0 Whetstine, 2009, Conducting research on the critically ill: an ethical perspective, Minerva Anestesiol, 75, 443 Kass, 2011, Length and complexity of US and international HIV consent forms from federal HIV network trials, J Gen Intern Med, 26, 1324, 10.1007/s11606-011-1778-6 Chenaud, 2006, Informed consent for research obtained during the intensive care unit stay, Crit Care, 10, R170, 10.1186/cc5120 Roupie, 2000, Patients’ preferences concerning medical information and surrogacy: results of a prospective study in a French emergency department, Intensive Care Med, 26, 52, 10.1007/s001340050011 Coppolino, 2001, Do surrogate decision makers provide accurate consent for intensive care research?, Chest, 119, 603, 10.1378/chest.119.2.603 Sulmasy, 1994, More talk, less paper: predicting the accuracy of substituted judgments, Am J Med, 96, 432, 10.1016/0002-9343(94)90170-8 Postma, 2015, Antibiotic treatment strategies for community-acquired pneumonia in adults, N Engl J Med, 372, 1312, 10.1056/NEJMoa1406330 Connolly, 2013, Randomized cluster crossover trials for reliable, efficient, comparative effectiveness testing: design of the Prevention of Arrhythmia Device Infection Trial (PADIT), Can J Cardiol, 29, 652, 10.1016/j.cjca.2013.01.020 Paul, 2015, Trimethoprim–sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial, BMJ, 350, h2219, 10.1136/bmj.h2219 Paul, 2015, External validity of a randomised controlled trial on the treatment of severe infections caused by MRSA, BMJ Open, 5, e008838, 10.1136/bmjopen-2015-008838 Khan, 2010, Quality and strength of evidence of the Infectious Diseases Society of America clinical practice guidelines, Clin Infect Dis, 51, 1147, 10.1086/656735 Silberzahn, 2015, Crowdsourced research: many hands make tight work, Nature, 526, 189, 10.1038/526189a Fiore, 2011, A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen, Clin Trials, 8, 183, 10.1177/1740774511398368 Friedman, 2010, Achieving a nationwide learning health system, Sci Transl Med, 2, 57cm29, 10.1126/scitranslmed.3001456 Institute of Medicine, 2007 Boucher, 2013, 10 × ’20 Progress—development of new drugs active against Gram-negative bacilli: an update from the Infectious Diseases Society of America, Clin Infect Dis, 56, 1685, 10.1093/cid/cit152