Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)

Springer Science and Business Media LLC - Tập 49 - Trang 2847-2852 - 2006
B. Littorin1,2, P. Blom3, A. Schölin4, H. J. Arnqvist5, G. Blohmé6, J. Bolinder7, A. Ekbom-Schnell8, J. W. Eriksson9, S. Gudbjörnsdottir10, L. Nyström11, J. Östman7, G. Sundkvist1
1Department of Clinical Sciences, University of Lund, Malmö University Hospital, Malmö, Sweden
2Södervärn Primary Health Care Centre, Malmö, Sweden
3Electra-Box Diagnostica, Tyresö, Sweden
4Department of Medical Science, Uppsala University, Uppsala, Sweden
5Department of Internal Medicine, Faculty of Health Sciences, University of Linköping, Linköping, Sweden
6Department of Internal Medicine, Söder Hospital, Stockholm, Sweden
7Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Huddinge, Sweden
8Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
9Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden
10Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
11Department of Public Health and Clinical Medicine, Epidemiology, Umeå University, Umeå, Sweden

Tóm tắt

Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes. The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15- to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age- and sex-matched control subjects (n=208). At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5±1.3 vs 96.7±2.0 nmol/l; p<0.0001). Eight years later, plasma 25OHD had decreased in patients (81.5±2.6 nmol/l; p=0.04). Plasma 25OHD levels were significantly lower in diabetic men than in diabetic women at diagnosis (77.9±1.4 vs 90.1±2.4 nmol/l; p<0.0001) and at follow-up (77.1±2.8 nmol/l vs 87.2±4.5 nmol/l; p=0.048). The plasma 25OHD level was lower at diagnosis of autoimmune type 1 diabetes than in control subjects, and may have a role in the development of type 1 diabetes. Plasma 25OHD levels were lower in men than in women with type 1 diabetes. This difference may be relevant to the high incidence of type 1 diabetes among young adult men.

Tài liệu tham khảo

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