Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway

PLoS ONE - Tập 12 Số 11 - Trang e0186520
Yang Cao1, Qing Ye2, Mengfei Zhuang1, Shuwu Xie3, Ruihua Zhong3, Jingang Cui4, Jieyun Zhou3, Yan Zhu3, Tingting Zhang1, Lin Cao3
1Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
3Department of Reproductive Pharmacology, NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China
4Clinical Research Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

PH Kodaman, 2015, Current strategies for endometriosis management, Obstet Gynecol Clin North Am, 42, 87, 10.1016/j.ogc.2014.10.005

SW Guo, 2009, Recurrence of endometriosis and its control, Hum Reprod Update, 15, 441, 10.1093/humupd/dmp007

T Matsumoto, 2015, Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and clear cell carcinomas, Am J Clin Pathol, 144, 452, 10.1309/AJCPZ5T2POOFMQVN

N Wang, 2014, Antiangiogenesis therapy of endometriosis using PAMAM as a gene vector in a noninvasive animal model, Biomed Res Int, 2014, 546479

S Carvalho Mde, 2015, Predictive factors for recurrence of ovarian endometrioma after laparoscopic excision, Rev Bras Ginecol Obstet, 37, 77

D Djokovic, 2014, Angiogenesis as a therapeutic target in endometriosis, Acta Med Port, 27, 489, 10.20344/amp.5244

MW Laschke, 2012, Anti-angiogenic treatment strategies for the therapy of endometriosis, Hum Reprod Update, 18, 682, 10.1093/humupd/dms026

S Liu, 2016, Efficacy of anti-VEGF/VEGFR agents on animal models of endometriosis: a systematic review and meta-analysis, PloSOne, 11, e0166658, 10.1371/journal.pone.0166658

M Mayerhofer, 2002, BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator,hypoxia inducible factor-1alpha,through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin, Blood, 100, 3767, 10.1182/blood-2002-01-0109

JW Kim, 2012, Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells, Cancer Biol Ther, 13, 504, 10.4161/cbt.19599

SH Chen, 2011, Changes of VEGF and MVD after treatment with ginsenoside Rg3 in rats with endometriosis, Chinese Medical Frontiers, 6, 26

L Steven, 2013, AVMA Guidelines for the Euthanasia of Animals, 2013, 20

W Wei, 2010, Experimental Methodology of Pharmacology, 68

RC Jones, 1984, The effect of luteinzing hormone releasing hormone (LRH) agonist(Wy-40972), levonorgestrel, danazol and ovariectomy on experimental endometriosis in the rat, Acta Endocrinol (Copenh), 106, 282, 10.1530/acta.0.1060282

H Zhang, 2010, 17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaBdependent pathway, Mol Cell Endocrinol, 317, 31, 10.1016/j.mce.2009.11.009

M Leconte, 2011, The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice, Am J Pathol, 179, 880, 10.1016/j.ajpath.2011.04.020

M Guba, 2002, Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis:involvement of vascular endothelial growth factor, Nat Med, 8, 128, 10.1038/nm0202-128

KK Chang, 2013, NME1 suppression of endometrial stromal cells promotes angiogenesis in the endometriotic milieu via stimulating the secretion of IL-8 and VEGF, Int J Clin Exp Pathol, 6, 2030

JX Liu, 2014, Marine compound catunaregin inhibits angiogenesis through the modulation of phosphorylation of akt and eNOS in vivo and in vitro, Mar Drugs, 12, 2790, 10.3390/md12052790

Z Kang, 2013, Protocatechuic acid induces angiogenesis through PI3K-Akt-eNOS-VEGF signalling pathway, Basic Clin Pharmacol Toxicol, 113, 221, 10.1111/bcpt.12094

SG Yeo, 2013, Increased expression of pattern recognition receptors and nitric oxide synthase in patients withendometriosis, Int J Med Sci, 10, 1199, 10.7150/ijms.5169

S Matsuzaki, 2015, Co-operation between the AKT and ERK signaling pathways may support growth of deep endometriosis in a fibrotic microenvironment in vitro, Hum Reprod, 30, 1606, 10.1093/humrep/dev108

ML Hull, 2003, Antiangiogenic agents are effective inhibiters of endometriosis, J Clin Endocinol Metab, 88, 2889, 10.1210/jc.2002-021912

S Matsuzaki, 2001, Immunohistochemical analysis of the role of angiogenic status in the vasculature of peritoneal endometriosis, Fertil Steril, 76, 712, 10.1016/S0015-0282(01)02003-9

N Ferrara, 2002, Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis:therapeutic implications, Semin Oncol, 29, 10, 10.1053/sonc.2002.37264

H Jie, 2011, Research progress of tumor angiogenesis inhibitors, Chin J New Drugs, 20, 2415

H Zhang, 2010, 17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaB-dependent pathway, Mol Cell Endocrinol, 317, 31, 10.1016/j.mce.2009.11.009