Impact of an Antibiotic-specific Sepsis Bundle on Appropriate and Timely Antibiotic Administration for Severe Sepsis in the Emergency Department

The Journal of Emergency Medicine - Tập 50 - Trang 79-88.e1 - 2016
Bethany A. Kalich1, Jennifer M. Maguire2, Stacy L. Campbell-Bright1, Abhi Mehrotra3, Tom Caffey4, Zeynep Tulu4, Feng-Chang Lin4, Shannon S. Carson2
1Department of Pharmacy, University of North Carolina Hospitals, Chapel Hill, North Carolina
2Division of Pulmonary and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina
3Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina
4University of North Carolina Hospitals, Chapel Hill, North Carolina

Tài liệu tham khảo

Dellinger, 2013, Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, Crit Care Med, 41, 580, 10.1097/CCM.0b013e31827e83af Kumar, 2006, Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock, Crit Care Med, 34, 1589, 10.1097/01.CCM.0000217961.75225.E9 Rivers, 2002, Early goal-directed therapy in the treatment of severe sepsis and septic shock, N Engl J Med, 57, ii8 Nguyen, 2007, Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality, Crit Care Med, 35, 1105, 10.1097/01.CCM.0000259463.33848.3D Levy, 2010, The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis, Crit Care Med, 38, 367, 10.1097/CCM.0b013e3181cb0cdc Shapiro, 2006, Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol, Crit Care Med, 34, 1025, 10.1097/01.CCM.0000206104.18647.A8 Gao, 2005, The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study, Crit Care, 9, R764, 10.1186/cc3909 Shorr, 2007, Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs?, Crit Care Med, 35, 1257, 10.1097/01.CCM.0000261886.65063.CC Kortgen, 2006, Implementation of an evidence-based “standard operating procedure” and outcome in septic shock, Crit Care Med, 34, 943, 10.1097/01.CCM.0000206112.32673.D4 Garnacho-Montero, 2003, Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis, Crit Care Med, 31, 2742, 10.1097/01.CCM.0000098031.24329.10 Kumar, 2009, Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock, Chest, 136, 1237, 10.1378/chest.09-0087 Harbarth, 2003, Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis, Am J Med, 115, 529, 10.1016/j.amjmed.2003.07.005 Micek, 2005, Predictors of hospital mortality for patients with severe sepsis treated with Drotrecogin alfa (activated), Pharmacotherapy, 25, 26, 10.1592/phco.25.1.26.55615 Kumar, 2010, Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis, Crit Care Med, 38, 1773, 10.1097/CCM.0b013e3181eb3ccd Mandell, 2007, Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults, Clin Infect Dis, 44, S27, 10.1086/511159 Ferrer, 2014, Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program, Crit Care Med, 42, 1749, 10.1097/CCM.0000000000000330 Yealy, 2014, A randomized trial of protocol-based care for early septic shock, N Engl J Med, 370, 1683, 10.1056/NEJMoa1401602 2005, Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia, Am J Respir Crit Care Med, 171, 388, 10.1164/rccm.200405-644ST Hooton, 2010, Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America, Clin Infect Dis Off Publ Infect Dis Soc Am, 50, 625, 10.1086/650482 Gupta, 2011, International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases, Clin Infect Dis, 52, e103, 10.1093/cid/ciq257 Solomkin, 2010, Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America, Clin Infect Dis, 50, 133, 10.1086/649554 Stevens, 2005, Practice guidelines for the diagnosis and management of skin and soft-tissue infections, Clin Infect Dis Off Publ Infect Dis Soc Am, 41, 1373, 10.1086/497143 Mermel, 2009, Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America, Clin Infect Dis, 49, 1, 10.1086/599376 Tunkel, 2004, Practice guidelines for the management of bacterial meningitis, Clin Infect Dis Off Publ Infect Dis Soc Am, 39, 1267, 10.1086/425368 Baddour, 2005, Circulation, 111, e394, 10.1161/CIRCULATIONAHA.105.165564 Dhainaut, 2003, The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results, Crit Care Med, 31, 2291, 10.1097/01.CCM.0000085089.88077.AF