The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFα and FGF7 in morphogenesis of mouse mammary epithelium

Adriance, 2005, Myoepithelial cells: good fences make good neighbors, Breast Cancer Res., 7, 190, 10.1186/bcr1286 Atwood, 2000, Progesterone induces side-branching of the ductal epithelium in the mammary glands of peripubertal mice, J. Endocrinol., 167, 39, 10.1677/joe.0.1670039 Ballif, 2001, Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals, Cell Growth Differ., 12, 397 Cabernard, 2005, Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila, Dev. Cell, 9, 831, 10.1016/j.devcel.2005.10.008 Coleman-Krnacik, 1994, Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development, Mol. Endocrinol., 8, 218 Corson, 2003, Spatial and temporal patterns of ERK signaling during mouse embryogenesis, Development, 130, 4527, 10.1242/dev.00669 Daniel, 1996, The role of TGF-beta in patterning and growth of the mammary ductal tree, J. Mammary Gland Biol. Neoplasia, 1, 331, 10.1007/BF02017389 Deugnier, 2006, Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line, Dev. Biol., 293, 414, 10.1016/j.ydbio.2006.02.007 Emerman, 1986, Cell size and shape changes in the myoepithelium of the mammary gland during differentiation, Anat. Rec., 216, 405, 10.1002/ar.1092160310 Faraldo, 2005, Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice, J. Mammary Gland Biol. Neoplasia, 10, 211, 10.1007/s10911-005-9582-8 Fata, 2001, Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle, Biol. Reprod., 65, 680, 10.1095/biolreprod65.3.680 Fata, 2004, Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes, Breast Cancer Res., 6, 1, 10.1186/bcr634 Gaggioli, 2005, HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1, Oncogene, 24, 1423, 10.1038/sj.onc.1208318 Grimm, 2006, Keratin 6 is not essential for mammary gland development, Breast Cancer Res., 8, R29, 10.1186/bcr1504 Gudjonsson, 2002, Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties, Genes Dev., 16, 693, 10.1101/gad.952602 Guo, 1996, Keratinocyte growth factor is required for hair development but not for wound healing, Genes Dev., 10, 165, 10.1101/gad.10.2.165 Hida, 2002, ERK and p38 MAP kinase are required for rat renal development, Kidney Int., 61, 1252, 10.1046/j.1523-1755.2002.00273.x Hirai, 1998, Epimorphin functions as a key morphoregulator for mammary epithelial cells, J. Cell Biol., 140, 159, 10.1083/jcb.140.1.159 Hirai, 2001, Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta, J. Cell Biol., 153, 785, 10.1083/jcb.153.4.785 Hovey, 2002, Establishing a framework for the functional mammary gland: from endocrinology to morphology, J. Mammary Gland Biol. Neoplasia, 7, 17, 10.1023/A:1015766322258 Karihaloo, 2004, Hepatocyte growth factor-mediated renal epithelial branching morphogenesis is regulated by glypican-4 expression, Mol. Cell. Biol., 24, 8745, 10.1128/MCB.24.19.8745-8752.2004 Kashimata, 2000, The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF, Dev. Biol., 220, 183, 10.1006/dbio.2000.9639 Kling, 2002, MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs, Am. J. Physiol.: Lung Cell. Mol. Physiol., 282, L370 Larsen, 2006, Cell and fibronectin dynamics during branching morphogenesis, J. Cell Sci., 119, 3376, 10.1242/jcs.03079 Li, 2003, Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells, Proc. Natl. Acad. Sci. U. S. A., 100, 15853, 10.1073/pnas.2136825100 Lin, 1995, Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice, J. Cell. Biol., 129, 1115, 10.1083/jcb.129.4.1115 Liscia, 1990, Transforming growth factor-alpha messenger RNA localization in the developing adult rat and human mammary gland by in situ hybridization, Dev. Biol., 140, 123, 10.1016/0012-1606(90)90059-R Luetteke, 1999, Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development, Development, 126, 2739, 10.1242/dev.126.12.2739 Mailleux, 2002, Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo, Development, 129, 53, 10.1242/dev.129.1.53 Maroun, 1999, The Gab1 PH domain is required for localization of Gab1 at sites of cell–cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase, Mol. Cell. Biol., 19, 1784, 10.1128/MCB.19.3.1784 Marshall, 1995, Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation, Cell, 80, 179, 10.1016/0092-8674(95)90401-8 Matsui, 1990, Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice, Cell, 61, 1147, 10.1016/0092-8674(90)90077-R Nelson, 2006, Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures, Science, 314, 298, 10.1126/science.1131000 Park, 2004, Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop, J. Invest. Dermatol., 123, 1012, 10.1111/j.0022-202X.2004.23487.x Parmar, 2004, Epithelial–stromal interactions in the mouse and human mammary gland in vivo, Endocr. Relat. Cancer, 11, 437, 10.1677/erc.1.00659 Pechoux, 1999, Human mammary luminal epithelial cells contain progenitors to myoepithelial cells, Dev. Biol., 206, 88, 10.1006/dbio.1998.9133 Pedchenko, 2000, Pattern of expression of the KGF receptor and its ligands KGF and FGF-10 during postnatal mouse mammary gland development, Mol. Reprod. Dev., 56, 441, 10.1002/1098-2795(200008)56:4<441::AID-MRD1>3.0.CO;2-C Qui, 1992, PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity, Neuron, 9, 705, 10.1016/0896-6273(92)90033-A Robinson, 2000, Side-branching in the mammary gland: the progesterone-Wnt connection, Genes Dev., 14, 889, 10.1101/gad.14.8.889 Roux, 2004, ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions, Microbiol. Mol. Biol. Rev., 68, 320, 10.1128/MMBR.68.2.320-344.2004 Sakai, 2003, Fibronectin requirement in branching morphogenesis, Nature, 423, 876, 10.1038/nature01712 Schedin, 2004, Mammary ECM composition and function are altered by reproductive state, Mol. Carcinog., 41, 207, 10.1002/mc.20058 Schlessinger, 2004, Common and distinct elements in cellular signaling via EGF and FGF receptors, Science, 306, 1506, 10.1126/science.1105396 Shackleton, 2006, Generation of a functional mammary gland from a single stem cell, Nature, 439, 84, 10.1038/nature04372 Simian, 2001, The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells, Development, 128, 3117, 10.1242/dev.128.16.3117 Sternlicht, 2006, Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis, Breast Cancer Res., 8, 201, 10.1186/bcr1368 Sternlicht, 2005, Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin, Development, 132, 3923, 10.1242/dev.01966 Traverse, 1992, Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor, Biochem. J., 288, 351, 10.1042/bj2880351 Wang, 2001, Cell differentiation lineage in the prostate, Differentiation, 68, 270, 10.1046/j.1432-0436.2001.680414.x Weaver, 2002, beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium, Cancer Cell, 2, 205, 10.1016/S1535-6108(02)00125-3 Welm, 2005, MET and MYC cooperate in mammary tumorigenesis, Proc. Natl. Acad. Sci. U. S. A., 102, 4324, 10.1073/pnas.0500470102 Wiesen, 1999, Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development, Development, 126, 335, 10.1242/dev.126.2.335 Wiseman, 2003, Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis, J. Cell Biol., 162, 1123, 10.1083/jcb.200302090 Xie, 1997, Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development, Mol. Endocrinol., 11, 1766, 10.1210/mend.11.12.0019 York, 1998, Rap1 mediates sustained MAP kinase activation induced by nerve growth factor, Nature, 392, 622, 10.1038/33451