Eliminating race-based reference ranges in haematology: a call to action

Gräsbeck, 2004, The evolution of the reference value concept, Clin Chem Lab Med, 42, 692, 10.1515/CCLM.2004.118 Cheng, 2004, Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race, Lab Hematol, 10, 42, 10.1532/LH96.04010 Beutler, 2005, Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume, Blood, 106, 740, 10.1182/blood-2005-02-0713 McLaren, 2001, Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey, Blood, 98, 2345, 10.1182/blood.V98.8.2345 Allen, 1998, Measurement of soluble transferrin receptor in serum of healthy adults, Clin Chem, 44, 35, 10.1093/clinchem/44.1.35 Powers Fedorowicz Thornburg, 2020, The anemias Brugnara, 2015, Diagnostic approach to the anemic patient, 293 Burns LJ, Lichtman MA, Kaushansky K, Prchal JT, Levi M. C. Linch D. Consultative hematology. In: Kaushansky K, Prchal JT, Burns LJ, Lichtman MA, Levi M, Linch DC, eds. Williams hematology, 10th edn. New York, NY: McGraw-Hill. Brugnara, 2016, Hematologic aspects of kidney disease, 1875 2008, ACOG Practice Bulletin No. 95: anemia in pregnancy, Obstet Gynecol, 112, 201, 10.1097/AOG.0b013e3181809c0d Marcewicz, 2017, Screening and treatment for iron deficiency anemia in women: results of a survey of obstetrician-gynecologists, Matern Child Health J, 21, 1627, 10.1007/s10995-016-2252-1 Short, 2013, Iron deficiency anemia: evaluation and management, Am Fam Physician, 87, 98 Artz, 2018, Hematology in aging, 2328 Chiossi, 2019, Reference intervals for hemoglobin and hematocrit in a low-risk pregnancy cohort: implications of racial differences, J Matern Fetal Neonatal Med, 32, 2897, 10.1080/14767058.2018.1452905 Vyas, 2020, Hidden in plain sight - reconsidering the use of race correction in clinical algorithms, N Engl J Med, 383, 874, 10.1056/NEJMms2004740 Norris, 2021, Removal of race from estimates of kidney function: first, do no harm, JAMA, 325, 135 Diao, 2021, Clinical implications of removing race from estimates of kidney function, JAMA, 325, 184, 10.1001/jama.2021.3461 Merz, 2021, When non-whiteness becomes a condition, Blood, 137, 13, 10.1182/blood.2020008600 Wolf, 2020, Examining “race” in physiology, Am J Physiol Heart Circ Physiol, 319, H1409, 10.1152/ajpheart.00698.2020 Eichelberger, 2018, Should race be used as a variable in research on preterm birth?, AMA J Ethics, 20, 296, 10.1001/journalofethics.2018.20.3.sect1-1803 Cunningham, 2017, Vital signs: racial disparities in age-specific mortality among blacks or African Americans - United States, 1999–2015, MMWR Morb Mortal Wkly Rep, 66, 444, 10.15585/mmwr.mm6617e1 Singh, 2017, Socioeconomic and racial/ethnic disparities in cancer mortality, incidence, and survival in the United States, 1950–2014: over six decades of changing patterns and widening inequalities, J Environ Public Health, 2017, 10.1155/2017/2819372 Hunt, 2014, Increasing Black:White disparities in breast cancer mortality in the 50 largest cities in the United States, Cancer Epidemiol, 38, 118, 10.1016/j.canep.2013.09.009 Tangel, 2019, Racial and ethnic disparities in maternal outcomes and the disadvantage of peripartum black women: a multistate analysis, 2007–2014, Am J Perinatol, 36, 835, 10.1055/s-0038-1675207 Sigurdson, 2019, at al. Racial/ethnic disparities in neonatal intensive care: a systematic review, Pediatrics, 144, 10.1542/peds.2018-3114 Price-Haywood, 2020, Hospitalization and mortality among Black patients and White patients with COVID-19, N Engl J Med, 382, 2534, 10.1056/NEJMsa2011686 Feagin, 2014, Systemic racism and U.S. health care, Soc Sci Med, 103, 7, 10.1016/j.socscimed.2013.09.006 Evans, 2020, Diagnosing and treating systemic racism, N Engl J Med, 383, 274, 10.1056/NEJMe2021693 Bailey, 2017, Structural racism and health inequities in the USA: evidence and interventions, Lancet, 389, 1453, 10.1016/S0140-6736(17)30569-X Collins, 2004, What we do and don't know about ‘race’, ‘ethnicity’, genetics and health at the dawn of the genome era, Nat Genet, 36, S13, 10.1038/ng1436 Robins, 2007, Hematologic reference values for African American children and adolescents, Am J Hematol, 82, 611, 10.1002/ajh.20848 1993, Institute of Medicine (US) Committee on the Prevention, Detection, and Management of Iron Deficiency Anemia Among U.S. Children and Women of Childbearing Age Anyane-Yeboa, 2020, Black race and public insurance are predictive of inappropriate evaluation of iron deficiency anemia and diarrhea, Dig Dis Sci Weisbord, 2007, Associations of race and ethnicity with anemia management among patients initiating renal replacement therapy, J Natl Med Assoc, 99, 1218 Barton, 2020, Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study, PLoS One, 15, 10.1371/journal.pone.0232125 Le, 2016, The prevalence of anemia and moderate-severe anemia in the US population (NHANES 2003-2012), PLoS One, 11, 10.1371/journal.pone.0166635 Gonzalez-Velez, 2020, Racial/ethnic differences in patients with anemia and folate deficiency, Int J Lab Hematol, 42, 403, 10.1111/ijlh.13205 Vichinsky, 2018, Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States, Pediatr Blood Cancer, 65, 10.1002/pbc.27067 Zacharski, 2000, Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data, Am Heart J, 140, 98, 10.1067/mhj.2000.106646 Pan, 2008, Insights into the ethnic differences in serum ferritin between black and white US adult men, Am J Hum Biol, 20, 406, 10.1002/ajhb.20745 Perry, 1992, Iron nutrition does not account for the hemoglobin differences between blacks and whites, J Nutr, 122, 1417, 10.1093/jn/122.7.1417 Rees, 1998, Alpha thalassaemia is associated with increased soluble transferrin receptor levels, Br J Haematol, 103, 365, 10.1046/j.1365-2141.1998.00971.x Duits, 2003, Erythropoiesis and serum sVCAM-1 levels in adults with sickle cell disease, Ann Hematol, 82, 171, 10.1007/s00277-003-0610-8 Mast, 1998, Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations, Clin Chem, 44, 45, 10.1093/clinchem/44.1.45 Lulla, 2010, Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease, Pediatr Blood Cancer, 55, 141, 10.1002/pbc.22471 Suárez-Ortegón, 2016, Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components, Br J Nutr, 116, 1165, 10.1017/S0007114516002968 Freixenet, 2009, Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia, Clin Chim Acta, 400, 111, 10.1016/j.cca.2008.10.019 Allen, 1998, Measurement of soluble transferrin receptor in serum of healthy adults, Clin Chem, 44, 35, 10.1093/clinchem/44.1.35 Brugnara, 1999, Reticulocyte hemoglobin content to diagnose iron deficiency in children, JAMA, 281, 2225, 10.1001/jama.281.23.2225 Mast, 2008, Reticulocyte hemoglobin content, Am J Hematol, 83, 307, 10.1002/ajh.21090 Gelaw, 2019, The role of reticulocyte hemoglobin content for diagnosis of iron deficiency and iron deficiency anemia, and monitoring of iron therapy: a literature review, Clin Lab, 65, 10.7754/Clin.Lab.2019.190315 Power-Hays, 2020, When actions speak louder than words - racism and sickle cell disease, N Engl J Med, 383, 1902, 10.1056/NEJMp2022125 Liu, 2019, Relations of anemia with the all-cause mortality and cardiovascular mortality in general population: a meta-analysis, Am J Med Sci, 358, 191, 10.1016/j.amjms.2019.05.016 Li, 2016, Anemia increases the mortality risk in patients with stroke: a meta-analysis of cohort studies, Sci Rep, 6 Smith, 2019, Maternal and perinatal morbidity and mortality associated with anemia in pregnancy, Obstet Gynecol, 134, 1234, 10.1097/AOG.0000000000003557 Wallace, 2020, Platelet and hemoglobin count at diagnosis are associated with survival in African American and Caucasian patients with colorectal cancer, Cancer Epidemiol, 67, 10.1016/j.canep.2020.101746 Chan, 2017, Black patients with colorectal cancer have more advanced cancer stage at time of diagnosis: a community-based safety-net hospital experience, J Community Health, 42, 724, 10.1007/s10900-016-0309-0 Lozoff, 2006, Long-lasting neural and behavioral effects of iron deficiency in infancy, Nutr Rev, 64, S34, 10.1301/nr.2006.may.S34-S43