Aescin: pharmacology, pharmacokinetics and therapeutic profile

Fournier, 1948 Tutin, 1968 Bombardelli, 1996, Aesculus hippocastanum L, Fitoterapia, 67, 483 Lorenz, 1960, Das therapeutische wirksame Prinzip der Rosskastanie (Aesculus hippocastanum), Arzneim-Forsch, 10, 263 Costantini, 1999, Escin in pharmaceutical oral dosage forms: quantitative densitometric HPTLC determination, Il Farmaco, 54, 728, 10.1016/S0014-827X(99)00090-7 Renger, 1990, Quantitative densitometric HPTLC determination of triterpenic saponins (escin) in horse-chestnut extract, J Planar Chromatogr, 3, 160 Griffini, 1997, Liquid chromatography-thermospray mass spectrometry analysis of beta-escin, Fitoterapia, 68, 520 Mrwa, 1986, Calcium-requirements for activation of skinned vascular smooth muscle from spontaneously hypertensive (SHRSP) and normotensive control rats, Life Sci, 38, 191, 10.1016/0024-3205(86)90011-1 Pearson, 1993, Vasodilator and vasoconstrictor substances produced by the endothelium, Rev Physiol Biochem Pharmacol, 122, 1, 10.1007/BFb0035273 Satoh, 1994, Augmented agonist-induced Ca++sensitization of coronary artery contraction in genetically hypertensive rats: evidence for altered signal transduction in the coronary smooth muscle cells, J Clin Invest, 94, 1397, 10.1172/JCI117475 Panigati, 1992, Farmacologia dell’escina, saponina dell’Aesculus hippocastanum L. Parte II. Farmacodinamica dell’escina. Capitolo II, Boll Chim Farm, 131, 284 Arnould, 1996, Effect of aescin on hypoxia-induced activation of human endothelial cells, Eur J Pharmacol, 315, 227, 10.1016/S0014-2999(96)00645-0 Enghofer, 1984, Die antiexudative Wirkung von Rosskastaniensamen Extrakt, Therapiewoche, 34, 4130 Bazzoni, 1991, Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation, Haematologica, 76, 491 Guillaume, 1994, Venotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract, Arzneim-Forsch, 44, 25 Bisler, 1986, Wirkung von Rosskastaniensamenextrakt auf die transkapillaere Filtration bei chronischer venoeser Insuffizienz, Dtsch Med Wochenschr, 111, 1321, 10.1055/s-2008-1068628 Facino, 1995, Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency, Arch Pharmacol, 328, 720, 10.1002/ardp.19953281006 Panigati, 1992, Farmacologia dell’escina, saponina dell’Aesculus hippocastanum L. Parte II. Farmacologia dell’escina. Capitolo I, Boll Chim Farm, 131, 242 Matsuda, 2000, Possible involvement of 5-HT and 5-HT2receptors in acceleration of gastrointestinal transit by escin Ib in mice, Life Sci, 66, 2233, 10.1016/S0024-3205(00)00551-8 Annoni, 1979, Venotonic activity of escin on the human saphenous vein, Arzneim-Forsch, 29, 672 Longiave, 1978, The mode of action of aescin on isolated veins: relationship with PGF2 α, Pharmacol Res Commun, 10, 145, 10.1016/S0031-6989(78)80072-1 Supplementary drugs and other substances: Aesculus, 1999 Panigati, 1992, Farmacologia dell’escina, saponina dell’Aesculus hippocastanum L. Parte III. Farmacocinetica e Tossicologia, Boll Chim Farm, 131, 320 von Kreybig, 1977, Toxizitaets- und Fertilitaetsstudien mit Aescin bei der Ratte, Arzneim-Forsch, 27, 1465 Frick, 2000, Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and daflon, Angiology, 51, 197, 10.1177/000331970005100303 Kobayashi, 1989, Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca sup 2+ release in smooth muscle, J Biol Chem, 264, 17997, 10.1016/S0021-9258(19)84670-7 Wilhelm, 1977, Thermometrische Untersuchungen der Wirksamkeit von Beta-Aescin auf den postoperativen Schwellungszustand, Med Klin, 72, 128 Oschmann, 1996, Pharmacokinetic of beta-escin after administration of various Aesculus extract containing formulations, Pharmazie, 51, 577 Schrodter, 1998, The validity of radioimmunologic determination of bioavailability of beta-escin in horse chestnut extracts, Arzneim-Forsch, 48, 905 Kunz, 1998, Bioavailability of escin after administration of two oral formulations containing aesculus extract, Arzneim-Forsch, 48, 822 Pittler, 1998, Horse-chestnut seed extract for chronic venous insufficiency, Arch Dermatol, 134, 1356, 10.1001/archderm.134.11.1356 Bielanski, 1999, Horse-chestnut seed extract for chronic venous insufficiency, J Fam Pract, 48, 171 Diehm, 1996, Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency, Lancet, 347, 292, 10.1016/S0140-6736(96)90467-5 Rehn, 1996, Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency, Arzneim-Forsch, 46, 483 Greeske, 1996, Rosskastaniensamenextrakt—ein wirksames Therapieprinzip in der Praxis, Fortschr Med, 114, 196 Pirard, 1976, Etude en double aveugle du Reparil en Proctologie, Rev Med Liege, 31, 343 Hefti, 1975, Klinischer Untersuchung von Aescin-Ampullen bei postoperativen und posttraumatischen Oedemen, Schweiz Rundsch Med Prax, 64, 73 Otto, 1974, Behandlung postoperativer Oedeme mit Reparil, Muensch Med Wochenschr, 116, 1085 Devin, 1976, Traitement préventif et curatif des oedémes en pathologie chirurgicale par le Réparil intraveineux, MM, 94, 106 Mouly, 1974, Tratement préventif et curatif de l’oedème post-opératoire en chirurgie plastique par le 1323 AN, GM de France, 81, 3127 Gualtieri, 1978, L’azione della escina nell’edema post-operatorio, Gazz Med It, 137, 339 Escribano, 1997, Contact urticaria due to aescin, Contact Dermatitis, 37, 233, 10.1111/j.1600-0536.1997.tb02440.x Wilhelm, 1975, Postoperative und posttraumatische Oedemprophylaxe und therapie, Med Klin, 70, 2079 Bastian, 1976, Nierenfunktion unter parenteraler Aescin-Behandlung, Med Kin, 71, 1295 Ascher, 1977, Renale Funktionsgroessen unter Na-Aescinat bei nierengesunden und nierenkranken Patienten, Therapiewoche, 52, 3