The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

Ahima, 1992, Sexual dimorphism in regulation of type II corticosteroid receptor immunoreactivity in the rat hippocampus, Endocrinology, 131, 1409, 10.1210/en.131.3.1409 Al-Damluji, 1988, Adrenergic mechanisms in the control of corticotropin secretion, J. Endocr., 119, 5, 10.1677/joe.0.1190005 Baulieu, 1992, Neurosteroids: an overview, 1 Bitran, 1991, Anxiolytic effects of 3α-hydroxy-5α(β)-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J Blaustein, 1988, Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain, Brain Res., 474, 1, 10.1016/0006-8993(88)90664-6 Brady, 1990, Altered expression of hypothalamic neuropeptide mRNA in food-restricted and food-deprived rats, Neuroendocrinology, 52, 441, 10.1159/000125626 Britton, 1992, Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin-releasing factor and stress, Pharmac. Biochem. Behav., 41, 399, 10.1016/0091-3057(92)90117-X Britton, 1985, Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test, Psychopharmacology, 86, 170, 10.1007/BF00431704 Buckingham, 1979, The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone, J. Physiol., 286, 331, 10.1113/jphysiol.1979.sp012622 Canonaco, 1993, Steroid hormones and receptors of the GABAA supramolecular complex, Neuroendocrinology, 57, 965, 10.1159/000126461 Dardenne, 1986, Thymic hormone-containing cells. VII. Adrenals and gonads control the in vivo secretion of thymulin and its plasmatic inhibitor, J. Immun., 136, 1303 Dunn, 1990, Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety and stress responses?, Brain Res. Rev., 15, 71, 10.1016/0165-0173(90)90012-D File, 1988, Anxiolytic and anxiogenic drugs: changes in behaviour and endocrine responses, Stress Med., 4, 221, 10.1002/smi.2460040407 Freeman, 1993, Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers, Neuroendocrinology, 58, 478, 10.1159/000126579 Fujii-Hanamoto, 1985, Progestin receptors in the thymus of ovariectomized immature rats, J. Endocr., 107, 223, 10.1677/joe.0.1070223 Gee, 1988, Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanisms of action, J. Pharmac. exp. Ther., 246, 803 Gustafsson, 1987, Biochemistry, molecular biology, and physiology of the glucocorticoid receptor, Endocr. Rev., 8, 185, 10.1210/edrv-8-2-185 Holsboer, 1992, The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia, Prog. Brain Res., 93, 385, 10.1016/S0079-6123(08)64586-0 Jingami, 1985, Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/β-lipotropin precursor mRNA in the pituitary in rats, Endocrinology, 117, 1314, 10.1210/endo-117-4-1314 Jingami, 1985, Cloning and sequence analysis of cDNA for rat corticotropin-releasing factor precursor, Fedn Eur. biochem. Socs Lett., 191, 63, 10.1016/0014-5793(85)80994-7 Kavaliers, 1987, Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice, Brain Res., 415, 393, 10.1016/0006-8993(87)90228-9 Kiss, 1992, Participation of α1-adrenergic receptors in the secretion of hypothalamic corticotropin-releasing hormone during stress, Neuroendocrinology, 56, 153, 10.1159/000126223 Koob, 1993, The role of corticotropin-releasing factor in behavioural responses to stress, 277 Lauber, 1991, Gene expression for estrogen and progesterone receptor mRNAs in rat brain and possible relations to sexually dimorphic functions, J. Steroid Biochem. Molec. Biol., 40, 53, 10.1016/0960-0760(91)90167-4 MacLusky, 1980, Progestin receptors in rat brain: distribution and properties of cytoplasmic progestin-binding sites, Endocrinology, 106, 192, 10.1210/endo-106-1-192 Majewska, 1986, Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science, 232, 1004, 10.1126/science.2422758 Majzoub, 1993, Second messenger regulation of mRNA for corticotropin-releasing factor, 30 Mezey, 1991, CRF-containing neurons in the hypothalamic paraventricular nucleus: regulation, especially by catecholamines, Front. Neuroendocr., 12, 23 Owens, 1989, Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain, Synapse, 4, 196, 10.1002/syn.890040304 Owens, 1991, Physiology and pharmacology of corticotropin-releasing factor, Pharmac. Rev., 43, 425 Paul, 1992, Neuroactive steroids, 6, 2311 Patchev, 1992, Increased plasma concentrations, hypothalamie content and in vitro release of arginine vasopressin in inflammatory disease-prone, hypothalamic corticotropin-releasing hormone-deficient Lewis rats, Endocrinology, 131, 1453, 10.1210/en.131.3.1453 Patchev, 1991, Adrenalectomy and experimental hypercorticalism modulate the basal, corticotropin-releasing hormone- and arginine-vasopressin-stimulated release of hypothalamic beta-endorphin, Neuroendocrinology, 54, 111, 10.1159/000125859 Plotsky, 1987, Regulation of hypophysiotropic actions mediating ACTH secretion, Ann. N.Y. Acad. Sci., 512, 205, 10.1111/j.1749-6632.1987.tb24962.x Puia, 1990, Neurosteroids act on recombinant human GABA receptors, Neuron, 4, 759, 10.1016/0896-6273(90)90202-Q Purdy, 1990, Synthesis, metabolism and pharma[;cological activity of 3α-hydroxy steroids which potentiate GABA receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes, J. med. Chem., 33, 1572, 10.1021/jm00168a008 Purdy, 1991, Stress-induced elevations of τ-aminobutyric acid type A receptor-active steroids in the rat brain, 88, 4553 Rivier, 1986, Mediation by corticotropin-releasing factor (CRF) of adenohypophysial hormone secretion, A. Rev. Physiol., 48, 475, 10.1146/annurev.ph.48.030186.002355 Romano, 1989, Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridization study, Molec. Endocrinol., 3, 1295, 10.1210/mend-3-8-1295 Rupprecht, 1993, Progesterone receptor mediated effects of neurosteroids, Neuron, 11, 523, 10.1016/0896-6273(93)90156-L Sawchenko, 1987, Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvo-cellular neurosecretory neurons: anatomic, peptide, and steroid specificity, J. Neurosci., 7, 1093, 10.1523/JNEUROSCI.07-04-01093.1987 Spinedi, 1991, Changes in hypothalamo-corticotrope axis after bilateral adrenalectomy: evidence for a median eminence site of glucocorticoid action, Neuroendocrinology, 53, 160, 10.1159/000125713 Suda, 1985, In vitro study of immunoreactive eorticotropin-releasing factor from the rat hypothalamus, Life Sci., 37, 1499, 10.1016/0024-3205(85)90181-X Suthers, 1976, Glucocorticoid receptors: evidence for a second non-glucocorticoid binding site, Endocrinology, 99, 260, 10.1210/endo-99-1-260 Szafarczyk, 1987, Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat, Endocrinology, 121, 883, 10.1210/endo-121-3-883 Tsagarakis, 1990, GABA modulation of CRF-41 secretion from rat hypothalamus in vitro, J. Neuroendocrinol., 2, 221, 10.1111/j.1365-2826.1990.tb00854.x Turner, 1985, Sexual dimorphism of glucocorticoid binding in rat brain, Brain Res., 343, 16, 10.1016/0006-8993(85)91153-9 Young, 1986, Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in rats, Neurosci. Lett., 70, 198, 10.1016/0304-3940(86)90463-5