Link between obesity and type 2 diabetes

Alain Golay1, J. Ybarra2
1Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, 24 rue Micheli-du-Crest, Switzerland.
2Division of Endocrinology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain

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Caterson, 2002, Obesity: epidemiology and possible prevention, Best Pract Res Clin Endocrinol Metab, 16, 595, 10.1053/beem.2002.0228

Formiguera X & Canton A. Obesity: epidemiology and clinical aspects. Best Pract Res Clin Gastroenterol 2004; 18, 1125-1146.

World Health Organization. Obesity and Overweight. Facts. Geneva: World Health Organization, 2004. Available at: http://www.who.int/dietphysicalactivity/media/en/gsfs_obesity.pdf. Accessed 16 November 2004.

Field, 2001, Impact of overweight on the risk of developing common chronic diseases during a 10-year period, Arch Intern Med, 161, 1581, 10.1001/archinte.161.13.1581

Visscher, 2001, The public health impact of obesity, Annu Rev Public Health, 22, 355, 10.1146/annurev.publhealth.22.1.355

Ford, 1997, Weight change and diabetes incidence: findings from a national cohort of US adults, Am J Epidemiol, 146, 214, 10.1093/oxfordjournals.aje.a009256

King, 1998, Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections, Diabetes Care, 21, 1414, 10.2337/diacare.21.9.1414

Zimmet, 2001, Global and societal implications of the diabetes epidemic, Nature, 414, 782, 10.1038/414782a

Stumvoll, 2005, Type 2 diabetes: principles of pathogenesis and therapy, Lancet, 365, 1333, 10.1016/S0140-6736(05)61032-X

Halpern A & Mancini MC. Diabesity: are weight loss medications effective? Treat Endocrinol 2005; 4: 65-74.

Field, 2001, Impact of overweight on the risk of developing common chronic diseases during a 10-year period, Arch Int Med, 161, 1581, 10.1001/archinte.161.13.1581

Stumvoll, 2005, The hyperbolic law - a 25-year perspective, Diabetologia, 48, 207, 10.1007/s00125-004-1657-3

Hockaday TDR. Letter to the editor. Diabetologia 2005; 48.

Turner, 1979, Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations, Metabolism, 28, 1086, 10.1016/0026-0495(79)90146-X

Stumvoll, 2003, Glucose allostasis, Diabetes, 52, 903, 10.2337/diabetes.52.4.903

Stumvoll, 2004, The role of glucose allostasis in type 2 diabetes, Rev Endocr Metab Disord, 5, 99, 10.1023/B:REMD.0000021430.56457.2c

Gerich, 1998, The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity, Endocr Rev, 19, 491, 10.1210/er.19.4.491

Warram, 1990, Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents, Ann Intern Med, 113, 909, 10.7326/0003-4819-113-12-909

Gulli, 1992, The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents, Diabetes, 41, 1575, 10.2337/diabetes.41.12.1575

Eriksson, 1989, Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus, N Engl J Med, 321, 337, 10.1056/NEJM198908103210601

Lillioja, 1993, Spraul M, et al, Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med, 329, 1988

DeFronzo, 1979, Glucose clamp technique: a method for quantifying insulin secretion and resistance, Am J Physiol, 273, E214

Ferrannini E & Mari A. How to measure insulin sensitivity. J Hypertens 1998; 16: 895-906.

Bergman, 1985, Assessment of insulin sensitivity in vivo, Endocr Rev, 6, 45, 10.1210/edrv-6-1-45

Ferrannini, 1996, Insulin action and age, European Group for the Study of Insulin Resistance (EGIR). Diabetes, 45, 947

Haffner, 1997, Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanic with NIDDM: the insulin resistance atherosclerosis study, Diabetes, 46, 63, 10.2337/diabetes.46.1.63

Clausen, 1996, Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians, J Clin Invest, 98, 1195, 10.1172/JCI118903

Camastra, 1999, Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man, EGIR (European Group for the Study of Insulin Resistance). Int J Obes, 23, 1307

Howard, 1998, Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. Metabolism, 47, 1174

Kahn, 2003, The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes, Diabetologia, 46, 3, 10.1007/s00125-002-1009-0

McClenaghan, 1999, Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines, Diabetes Obes Metab, 1, 137, 10.1046/j.1463-1326.1999.00017.x

Ferrannini, 1997, Lalic N & Mingrone G, Insulin resistance and hypersecretion in obesity. J Clin Invest, 100, 1166

Ferrannini, 2004, E & Mari A, Beta cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia, 47, 943

Haffner, 1996, A prospective analysis of the HOMA model: the Mexico city diabetes study, Diabetes Care, 19, 1138, 10.2337/diacare.19.10.1138

Golay, 1988, Metabolic bases of obesity and non insulin-dependent diabetes mellitus, Diabetes Metab Rev, 4, 727, 10.1002/dmr.5610040803

Felber, 1988, The metabolic consequences of long-term human obesity, Int J Obes, 13, 377

Mari, 2002, Meal and oral glucose tests for assessment of beta-cell function: modelling analysis in normal subjects, Am J Physiol Endocrinol Metab, 283, E1159, 10.1152/ajpendo.00093.2002

Ferrannini, 2003, role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance, Diabetologia, 46, 1211, 10.1007/s00125-003-1169-6

Jallut, 1990, Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism, Metabolism, 39, 1068, 10.1016/0026-0495(90)90168-C

Golay, 1985, of weight loss on glucose disposal in obese and obese diabetic patients, Int J Obes, 9, 181

Golay, 2002, defect of insulin action on glycogen synthase in obesity and diabetes, Metabolism, 51, 549, 10.1053/meta.2002.31972

Ferrannini, 2005, function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis, J Clin Endocrinol Metab, 90, 493, 10.1210/jc.2004-1133

Ferrannini, 2004, Mode of onset of type 2 diabetes from normal or impaired glucose tolerance, Diabetes, 53, 160, 10.2337/diabetes.53.1.160

Boden, 1993, Effects of age and body fat on insulin resistance in healthy men, Diabetes Care, 16, 728, 10.2337/diacare.16.5.728

Russel, 2003, peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?, FEBS Letters, 551, 104, 10.1016/S0014-5793(03)00875-5

Wojtaszewski, 2000, Insulin signalling and insulin sensitivity after exercise in human skeletal muscle, Diabetes, 49, 325, 10.2337/diabetes.49.3.325

Houmard, 1991, Elevated skeletal muscle glucose transport levels in exercise-trained middle-aged men, Am J Physiol, 261, E437

Randle, 1963, The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus, Lancet, 1, 785, 10.1016/S0140-6736(63)91500-9

Heilbronn, 2004, & Ravussin E, Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes, 28, S12

Assimacopoulos-Jeannet, 2004, storage in pancreas and in insulin-sensitive tissues in pathogenesis of type 2 diabetes, Int J Obes, 28, S53, 10.1038/sj.ijo.0802857

Lam, 2003, Mechanisms of free fatty acid-induced increase in hepatic glucose production, Am J Physiol Endocrinol Metab, 284, E12

Boden, 2001, Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes, Diabetes, 50, 810, 10.2337/diabetes.50.4.810

Boden, 2001, Pathogenesis of type 2 diabetes, Insulin resistance. Endocrinol Metab Clin North Am, 30, 801, 10.1016/S0889-8529(05)70216-4

Boden, 1994, Mechanisms of fatty acid-induced inhibition of glucose uptake, J Clin Invest, 93, 2438, 10.1172/JCI117252

Boden, 2001, Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects, Diabetes, 50, 1612, 10.2337/diabetes.50.7.1612

Ravichandran, 2000, Protein kinase C-sigma phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin, J Biol Chem, 276, 3543, 10.1074/jbc.M007231200

Boden G & Chen X. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 1995; 96: 1261-1268.

Meylan, 1987, Metabolic factors in the insulin resistance in human obesity, Metabolism, 36, 256, 10.1016/0026-0495(87)90185-5

Felber, 2002, JP & Golay A, Pathways from obesity to diabetes. Int J Obes, 26, 539

Golay, 1995, Effect of lipid oxidation on the regulation of glucose utilization in obese patients, Acta Diabetol, 32, 44, 10.1007/BF00581044

Santomauro, 1999, Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and non-diabetic subjects, Diabetes, 48, 1836, 10.2337/diabetes.48.9.1836

Munger, 1993, Correlations of glycogen synthase and phosphorylase activities with glycogen concentration in human muscle biopsies, Evidence for a double feed-back mechanism regulating glycogen synthesis and breakdown. Metabolism, 42, 36

Schulman, 2000, Cellular mechanisms of insulin resistance, J Clin Invest, 106, 171, 10.1172/JCI10583

Dresner, 1999, Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity, J Clin Invest, 103, 253, 10.1172/JCI5001

Clausen, 1996, Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors, J Clin Invest, 98, 1195, 10.1172/JCI118903

Despres, 1995, The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications, Int J Obes, 19, S76

Banerji, 1995, Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?, Diabetes, 44, 141, 10.2337/diabetes.44.2.141

Albu, 1997, Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women, Diabetes, 46, 456, 10.2337/diabetes.46.3.456

Gastaldelli, 2002, Metabolic effects of visceral fat accumulation in type 2 diabetes, J Clin Endocrinol Metab, 87, 5098, 10.1210/jc.2002-020696

Brocha, 2000, Visceral adipose tissue is an independent correlate of glucose disposal in older obese post-menopausal women, J Clin Endocrinol Metab, 85, 2378, 10.1210/jc.85.7.2378

Zierath, 1998, Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocyte: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway, Diabetologia, 41, 1343, 10.1007/s001250051075

Gastaldelli, 2004, Separate contribution of diabetes, total fat mass and fat topography to glucose production, gluconeogenesis, and glycogenolysis, J Clin Endocrinol Metab, 89, 3914, 10.1210/jc.2003-031941

Goodpaster, 1997, Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat, Diabetes, 46, 1579, 10.2337/diabetes.46.10.1579

Goodpaster, 1998, Role of muscle in triglyceride metabolism, Curr Opin Lipidol, 9, 231, 10.1097/00041433-199806000-00008

Kelley, 2002, Muscle triglyceride and insulin resistance, Annu Rev Nutr, 22, 325, 10.1146/annurev.nutr.22.010402.102912

Szczepaniak, 1999, Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo, Am J Physiol, 276, E977

Perseghin, 1999, Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic patients, Diabetes, 48, 1600, 10.2337/diabetes.48.8.1600

Krssak, 1999, Falk Petersen K. Dresner A. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study, Diabetologia, 42, 113, 10.1007/s001250051123

Kim, 2001, Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance, Proc Natl Acad Sci USA, 98, 7522, 10.1073/pnas.121164498

Oakes, 1997, Diet induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA, Diabetes, 46, 2022, 10.2337/diabetes.46.12.2022

Dobbins, 2001, Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats, Diabetes, 50, 123, 10.2337/diabetes.50.1.123

Hajri, 2002, Bonen A & Abumrad NA, Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest, 109, 1381

Bachmann, 2001, Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans, Diabetes, 50, 2579, 10.2337/diabetes.50.11.2579

Goodpaster, 1999, Effects of weight loss on regional fat distribution and insulin sensitivity in obesity, Diabetes, 48, 839, 10.2337/diabetes.48.4.839

Greco, 2002, resistance in morbid obesity: reversal with intramyocellular fat depletion, Diabetes, 51, 144, 10.2337/diabetes.51.1.144

Hegarty, 2002, Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats, Diabetes, 51, 1477, 10.2337/diabetes.51.5.1477

Kelley, 2002, Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes, Diabetes, 51, 2944, 10.2337/diabetes.51.10.2944

Petersen, 2004, Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes, N Engl J Med, 350, 664, 10.1056/NEJMoa031314

Smith, 2000, Fat and carbohydrate balances during adaptation to a high-fat, Am J Clin Nutr, 71, 450, 10.1093/ajcn/71.2.450

Berthon, 1998, Human skeletal muscle carnitine palmitoyltransferase I activity determined in isolated intact mitochondria, J Appl Physiol, 85, 148, 10.1152/jappl.1998.85.1.148

Goodpaster, 2001, Watkins S & Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes, J Clin Endocrinol Metab, 86, 5755, 10.1210/jc.86.12.5755

Kelley, 1999, Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss, Am J Physiol, 277, E1130

Bobbioni-Harsch, 2000, Economy hampers body weight loss after gastric bypass, J Clin Endocrinol Metab, 85, 4695, 10.1210/jc.85.12.4695

Weyer, 2000, Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance, Diabetologia, 43, 1498, 10.1007/s001250051560