Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice

Lu, 2008, CYP2E1 and oxidative liver injury by alcohol, Free Radic Biol Med, 44, 723, 10.1016/j.freeradbiomed.2007.11.004 De Minicis, 2008, Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex, J Gastroenterol Hepatol, 23, S98, 10.1111/j.1440-1746.2007.05277.x Puntarulo, 1989, Chemiluminescence from acetaldehyde oxidation by xanthine oxidase involves generation of and interactions with hydroxyl radicals, Alcohol Clin Exp Res, 13, 84, 10.1111/j.1530-0277.1989.tb00288.x Shaw, 1990, The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat, Biochem J, 268, 579, 10.1042/bj2680579 Rhee, 2005, Controlled elimination of intracellular H2O2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification, Antioxid Redox Signal, 7, 619, 10.1089/ars.2005.7.619 Jones, 1981, Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2, Arch Biochem Biophys, 210, 505, 10.1016/0003-9861(81)90215-0 Chance, 1979, Hydroperoxide metabolism in mammalian organs, Physiol Rev, 59, 527, 10.1152/physrev.1979.59.3.527 Gong, 2006, Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1, Hepatology, 43, 144, 10.1002/hep.21004 Kinsell, 1947, Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage, Science, 106, 589, 10.1126/science.106.2763.589 Duce, 1988, S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis, Hepatology, 8, 65, 10.1002/hep.1840080113 Garcı´a-Tevijano, 2001, Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis, Hypertension, 38, 1217, 10.1161/hy1101.099499 Halsted, 1996, Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation, Hepatology, 23, 497, 10.1002/hep.510230314 Lee, 2004, Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis, Alcohol Clin Exp Res, 28, 173, 10.1097/01.ALC.0000108654.77178.03 Esfandiari, 2005, Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs, Am J Physiol Gastrointest Liver Physiol, 289, G54, 10.1152/ajpgi.00542.2004 Ji, 2003, Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice, Gastroenterology, 124, 1488, 10.1016/S0016-5085(03)00276-2 Fernández-Checa, 2002, S-Adenosyl-l-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease, Alcohol, 27, 179, 10.1016/S0741-8329(02)00229-X Kim, 2003, Alterations in hepatic metabolism of sulfur-containing amino acids induced by ethanol in rats, Amino Acids, 24, 103, 10.1007/s00726-002-0324-6 Reitman, 1957, Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases, Am J Clin Pathol, 28, 56, 10.1093/ajcp/28.1.56 Volpi, 1998, Improvement in the high-performance liquid chromatography malondialdehyde level determination in normal human plasma, J Chromatogr B Biomed Sci Appl, 713, 433, 10.1016/S0378-4347(98)00195-9 Griffith, 1980, Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine, Anal Biochem, 106, 207, 10.1016/0003-2697(80)90139-6 Gaitonde, 1967, A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids, Biochem J, 104, 627, 10.1042/bj1040627 She, 1994, A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver, Biochem Biophys Res Commun, 205, 1748, 10.1006/bbrc.1994.2871 Carducci, 1999, Automated high-performance liquid chromatographic method for the determination of homocysteine in plasma samples, J Chromatogr A, 846, 93, 10.1016/S0021-9673(98)01091-7 Rajendra, 1987, High performance liquid chromatographic determination of amino acids in biological samples by precolumn derivatization with O-phthaldehyde, J Liq Chromatogr, 10, 941, 10.1080/01483918708066746 Ide, 1997, Simple high-performance liquid chromatographic method for assaying cysteinesulfinic acid decarboxylase activity in rat tissue, J Chromatogr B Biomed Sci Appl, 694, 325, 10.1016/S0378-4347(97)00128-X Sánchez-Góngora, 1997, Interaction of liver methionine adenosyltransferase with hydroxyl radical, FASEB J, 11, 1013, 10.1096/fasebj.11.12.9337154 Ruiz, 1998, Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation, Hepatology, 28, 1051, 10.1002/hep.510280420 Kotb, 1997, Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products, Trends Genet, 13, 51, 10.1016/S0168-9525(97)01013-5 Avila, 2000, Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma, J Hepatol, 33, 907, 10.1016/S0168-8278(00)80122-1 Lu, 2000, Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver, Am J Physiol Gastrointest Liver Physiol, 279, G178, 10.1152/ajpgi.2000.279.1.G178 Lu, 2001, Methionine adenosyltransferase 1A KO mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation, Proc Natl Acad Sci USA, 98, 5560, 10.1073/pnas.091016398 Kim, 2008, Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation, Biochem Biophys Res Commun, 368, 893, 10.1016/j.bbrc.2008.02.003 Kwon, 2009, Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats, J Nutr, 139, 63, 10.3945/jn.108.094771 Song, 2003, S-Adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice, J Nutr Biochem, 14, 591, 10.1016/S0955-2863(03)00116-5 Gassó, 1996, Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis, J Hepatol, 25, 200, 10.1016/S0168-8278(96)80074-2 Wu, 1996, Protective effect of S-adenosyl-l-methionine on bromobenzene- and d-galactosamine-induced toxicity to isolated rat hepatocytes, Hepatology, 23, 359 Mato, 1997, S-Adenosylmethionine synthesis: molecular mechanisms and clinical implications, Pharmacol Ther, 73, 265, 10.1016/S0163-7258(96)00197-0 Lieber, 1999, Role of S-adenosyl-l-methionine in the treatment of liver diseases, J Hepatol, 30, 1155, 10.1016/S0168-8278(99)80274-8 Chawla, 1998, S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury, Am J Physiol Gastrointest Liver Physiol, 275, G125, 10.1152/ajpgi.1998.275.1.G125 Pastor, 1996, Microsomal function in biliary obstructed rats: effects of S-adenosylmethionine, J Hepatol, 24, 353, 10.1016/S0168-8278(96)80016-X Evans, 1997, Antioxidant properties of S-adenosyl-l-methionine: a proposed addition to organ storage fluids, Free Radic Biol Med, 23, 1002, 10.1016/S0891-5849(97)00124-X Caro, 2004, Antioxidant properties of S-adenosyl-l-methionine in Fe2+-initiated oxidations, Free Radic Biol Med, 36, 1303, 10.1016/j.freeradbiomed.2004.02.015 Kharbanda, 2005, Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine, Biochem Pharmacol, 70, 1883, 10.1016/j.bcp.2005.09.021 Kharbanda, 2007, Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-l-isoaspartyl methyltransferase activity, J Hepatol, 46, 1119, 10.1016/j.jhep.2007.01.026 Kharbanda, 2007, Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, J Hepatol, 46, 314, 10.1016/j.jhep.2006.08.024 Werstuck, 2001, Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways, J Clin Invest, 107, 1263, 10.1172/JCI11596 Song, 2008, Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease, Hepatology, 47, 867, 10.1002/hep.22074 Meister, 1983, Glutathione, Annu Rev Biochem, 52, 711, 10.1146/annurev.bi.52.070183.003431 Lee, 2004, Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level, J Nutr Biochem, 15, 112, 10.1016/j.jnutbio.2003.10.005 Stipanuk, 2006, Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism, J Nutr, 136, 1652S, 10.1093/jn/136.6.1652S Lieber CS. Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968–1998) – a review. Alcohol Clin Exp Res 1999;23:991–1007. Vasiliou, 2006, CYP2E1 and catalase influence ethanol sensitivity in the central nervous system, Pharmacogenet Genomics, 16, 51, 10.1097/01.fpc.0000182777.95555.56