Enhancing radiotherapy outcomes in rectal cancer: A systematic review of targeting hypoxia-induced radioresistance

Clinical and Translational Radiation Oncology - Tập 44 - Trang 100695 - 2024
Matthew Fok1, Rhianna Hill1, Hayley Fowler1, Rachael Clifford1, Aaron Kler1, Jayanma Uzzi-Daniel1, Sonia Rocha1, Gabrielle Grundy1, Jason Parsons2, Dale Vimalachandran1,3
1Institute of Systems, Molecular and Integrative Biology University of Liverpool, UK
2Institute of Cancer and Genomic Sciences, University of Birmingham, UK
3Countess of Chester Hospital, Colorectal Surgery Department, Chester, UK

Tài liệu tham khảo

Feeney, 2019, Neoadjuvant radiotherapy for rectal cancer management, World J Gastroenterol, 25, 4850, 10.3748/wjg.v25.i33.4850 Kuremsky, 2009, Biomarkers for response to neoadjuvant chemoradiation for rectal cancer, Int J Radiat Oncol Biol Phys, 74, 673, 10.1016/j.ijrobp.2009.03.003 Li M, Xiao Q, Venkatachalam N, Hofheinz RD, Veldwijk MR, Herskind C, et al. Predicting response to neoadjuvant chemoradiotherapy in rectal cancer: from biomarkers to tumor models. Ther Adv Med Oncol. 2022;14:17588359221077972. Joye, 2014, Early and late toxicity of radiotherapy for rectal cancer, Recent Results Cancer Res, 203, 189, 10.1007/978-3-319-08060-4_13 Evans, 2003, Prognostic significance of tumor oxygenation in humans, Cancer Lett, 195, 1, 10.1016/S0304-3835(03)00012-0 Vaupel, 2007, Hypoxia in cancer: significance and impact on clinical outcome, Cancer Metastasis Rev, 26, 225, 10.1007/s10555-007-9055-1 Wilson, 2011, Targeting hypoxia in cancer therapy, Nat Rev Cancer, 11, 393, 10.1038/nrc3064 Muz, 2015, The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy, Hypoxia (auckl), 3, 83, 10.2147/HP.S93413 Chen, 2021, Genome-Wide analysis reveals hypoxic microenvironment is associated with immunosuppression in poor survival of stage II/III colorectal cancer patients, Front Med, 8 Yang, 2020, Prognostic value of a hypoxia-related microRNA signature in patients with colorectal cancer, Aging (Albany NY), 12, 35, 10.18632/aging.102228 Qiao, 2023, Identification of a hypoxia-related gene prognostic signature in colorectal cancer based on bulk and single-cell RNA-seq, Sci Rep, 13, 2503, 10.1038/s41598-023-29718-2 Zou, 2019, A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients, Cancer Cell Int, 19(1):243 Dietz, 2008, Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study, Dis Colon Rectum, 51, 1641, 10.1007/s10350-008-9420-3 Grimes, 2015, A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio, Biomed Phys Eng Express, 1 Bouleftour, 2021, A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy, Med Sci Monit, 27, e934116, 10.12659/MSM.934116 Ziello, 2007, Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia, Yale J Biol Med, 80, 51 Xia, 2018, The role of HIF-1α in chemo-/radioresistant tumors, Onco Targets Ther, 11, 3003, 10.2147/OTT.S158206 Batie, 2019, Hypoxia induces rapid changes to histone methylation and reprograms chromatin, Science, 363, 1222, 10.1126/science.aau5870 Chakraborty, 2019, Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate, Science, 363, 1217, 10.1126/science.aaw1026 D'Ignazio L, Batie M, Rocha S. Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB. Biomedicines. 2017;5(2). Druker, 2021, Role of Hypoxia in the Control of the Cell Cycle, Int J Mol Sci, 22, 10.3390/ijms22094874 Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook. Macleod, 2004, Pooling of animal experimental data reveals influence of study design and publication bias, Stroke, 35, 1203, 10.1161/01.STR.0000125719.25853.20 de Mey, 2018, Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption, Front Pharmacol, 9, 1073, 10.3389/fphar.2018.01073 De Bruycker, 2019, Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [18F]HX4 PET imaging study in colorectal cancer xenografts, EJNMMI Research, 9, 74, 10.1186/s13550-019-0543-4 Janssens, 1999, Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation, Br J Cancer, 79, 1085, 10.1038/sj.bjc.6690173 Sanduleanu, 2020, Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer, Cancers (basel), 12, 10.3390/cancers12051322 Groselj, 2013, Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair, Br J Cancer, 108, 748, 10.1038/bjc.2013.21 Saelen, 2012, Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma, Radiat Oncol, 7, 165, 10.1186/1748-717X-7-165 Ashton, 2016, The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia, Nat Commun, 7, 12308, 10.1038/ncomms12308 Haynes, 2018, Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer, Clin Cancer Res, 24, 2116, 10.1158/1078-0432.CCR-17-1715 Glick, 2010, Autophagy: cellular and molecular mechanisms, J Pathol, 221, 3, 10.1002/path.2697 Classen, 2019, Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells, Exp Cell Res, 374, 29, 10.1016/j.yexcr.2018.11.004 Sun, 2015, Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells, Int J Oncol, 46, 750, 10.3892/ijo.2014.2745 Decuypere, 2012, Regulation of the autophagic bcl-2/beclin 1 interaction, Cells, 1, 284, 10.3390/cells1030284 Xu, 2013, The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions, PLoS One, 8, e63232, 10.1371/journal.pone.0063232 Hill, 2023, The Role of Autophagy in Hypoxia-Induced Radioresistance, Radiother Oncol, 109951 Kawai, 2017, Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis, Int J Oncol, 50, 525, 10.3892/ijo.2016.3814 Fletcher, 2022, The measurement and modification of hypoxia in colorectal cancer: overlooked but not forgotten, Gastroenterol Rep (oxf), 10, goac042, 10.1093/gastro/goac042 Clifford, 2021, Metformin as a radiosensitiser for pelvic malignancy: A systematic review of the literature, Eur J Surg Oncol, 47, 1252, 10.1016/j.ejso.2020.12.009 Chen, 2009, HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells, Cancer Biother Radiopharm, 24, 689 Carrier, 2013, Chromatin Modulation by Histone Deacetylase Inhibitors: Impact on Cellular Sensitivity to Ionizing Radiation, Mol Cell Pharm, 5, 51 Falk, 2007, Chromatin dynamics during DSB repair, Biochim Biophys Acta, 1773, 1534, 10.1016/j.bbamcr.2007.07.002 Munshi, 2005, Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity, Clin Cancer Res, 11, 4912, 10.1158/1078-0432.CCR-04-2088 Collier, 2023, Functional crosstalk between chromatin and hypoxia signalling, Cell Signal, 106, 10.1016/j.cellsig.2023.110660 Melvin, 2012, Chromatin as an oxygen sensor and active player in the hypoxia response, Cell Signal, 24, 35, 10.1016/j.cellsig.2011.08.019 Zhang, 2017, Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha, Oncotarget, 8, 56110, 10.18632/oncotarget.18125 Li, 2021, The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy, Front Pharmacol, 12 Baggish, 2002, Antiparasitic agent atovaquone, Antimicrob Agents Chemother, 46, 1163, 10.1128/AAC.46.5.1163-1173.2002 Gupta, 2019, Atovaquone: An Antiprotozoal Drug Suppresses Primary and Resistant Breast Tumor Growth by Inhibiting HER2/β-Catenin Signaling, Mol Cancer Ther, 18, 1708, 10.1158/1535-7163.MCT-18-1286 Semenza, 2003, Targeting HIF-1 for cancer therapy, Nat Rev Cancer, 3, 721, 10.1038/nrc1187 Havelund, 2011, Pretreatment HIF-1α and GLUT-1 expressions do not correlate with outcome after preoperative chemoradiotherapy in rectal cancer, Anticancer Res, 31, 1559 Tan, 2016, Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors, Neoplasia, 18, 347, 10.1016/j.neo.2016.04.003 Jing, 2019, Role of hypoxia in cancer therapy by regulating the tumor microenvironment, Mol Cancer, 18, 157, 10.1186/s12943-019-1089-9 Hansen, 2021, Angiogenesis Inhibitors for Colorectal Cancer. A Review of the Clinical Data, Cancers (basel), 13, 10.3390/cancers13051031 Miyazaki, 2014, Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts, Int J Cancer, 135, 295, 10.1002/ijc.28686 Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol. 1998;46(2):135-46. Bonnet, 2018, Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides, J Med Chem, 61, 1241, 10.1021/acs.jmedchem.7b01678 Hill, 2022, Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma, Cancers (basel), 14, 10.3390/cancers14174130 van der Wiel, 2021, Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506, Mol Cancer Ther, 20, 2372, 10.1158/1535-7163.MCT-21-0406 Jeong, 2022, Proton Tumor Control Relative Biological Effectiveness (RBE) Estimated for Various Fractionation Schedules and Hypoxia Levels, Int J Radiat Oncol*Biol*Phys, 114, e507, 10.1016/j.ijrobp.2022.07.2075 Fok, 2021, Proton beam therapy in rectal cancer: A systematic review and meta-analysis, Surg Oncol, 38, 10.1016/j.suronc.2021.101638 Köthe, 2021, Investigating the potential of proton therapy for hypoxia-targeted dose escalation in non-small cell lung cancer, Radiat Oncol, 16, 199, 10.1186/s13014-021-01914-2 Melia, 2023, DNA damage and repair dependencies of ionising radiation modalities, Biosci Rep, 43, 10.1042/BSR20222586