Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

Mucosal Immunology - Tập 6 - Trang 797-806 - 2013
M R Edwards1,2,3,4, N Regamey5,4, M Vareille5, E Kieninger5, A Gupta2,6, A Shoemark2,6, S Saglani2,6, A Sykes1,2,3, J Macintyre1,2,3, J Davies2,6, C Bossley2,6, A Bush2,6, S L Johnston1,2,3
1Respiratory Medicine, St Mary's Campus, National Heart Lung Institute, London, UK
2MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK
3Centre for Respiratory Infections, Imperial College, London, UK
4these authors contributed equally to this work
5Division of Paediatric Respiratory Medicine, Department of Paediatrics and Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
6Respiratory Paediatrics, Royal Brompton NHS Trust, Imperial College, London, UK

Tài liệu tham khảo

Johnston, 1995, Community study of role of viral infections in exacerbations of asthma in 9-11 year old children, BMJ, 310,, 1225, 10.1136/bmj.310.6989.1225 Message, 2008, Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production, Proc. Natl. Acad. Sci. USA, 105,, 13562, 10.1073/pnas.0804181105 Corne, 2002, Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study, Lancet, 359,, 831, 10.1016/S0140-6736(02)07953-9 Johnston, 2005, The September epidemic of asthma exacerbations in children: a search for etiology, J. Allergy Clin. Immunol., 115,, 132, 10.1016/j.jaci.2004.09.025 Grunberg, 2001, Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection, Am. J. Respir. Crit. Care Med., 164,, 1816, 10.1164/ajrccm.164.10.2102118 Pauwels, 1997, Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group, N. Engl. J. Med., 337,, 1405, 10.1056/NEJM199711133372001 Pauwels, 2003, Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial, Lancet, 361,, 1071, 10.1016/S0140-6736(03)12891-7 FitzGerald, 2004, Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations, Thorax, 59,, 550, 10.1136/thx.2003.014936 Bel, 2011, Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI), Thorax, 66,, 910, 10.1136/thx.2010.153643 Bossley, 2012, Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines, J. Allergy Clin. Immunol., 129,, 974, 10.1016/j.jaci.2012.01.059 Baraldo, S. et al. Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. J. Allergy Clin. Immunol. (2012) (in press). Wark, 2005, Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus, J. Exp. Med., 201,, 937, 10.1084/jem.20041901 Contoli, 2006, Role of deficient type III interferon-lambda production in asthma exacerbations, Nat. Med., 12,, 1023, 10.1038/nm1462 Uller, 2010, Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma, Thorax, 65,, 626, 10.1136/thx.2009.125930 Iikura, 2011, Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro, Int Arch. Allergy Immunol., 155, 27, 10.1159/000327262 Khaitov, M.R. [Acute respiratory viral infections and bronchial asthma. Cellular and molecular aspects of the problem]. Zh Mikrobiol. Epidemiol. Immunobiol. 84–93 (2002). Wang, 2009, Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses, J. Immunol., 183,, 6989, 10.4049/jimmunol.0901386 Slater, 2010, Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium, PLoS Pathog., 6,, e1001178, 10.1371/journal.ppat.1001178 Kotenko, 2003, IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex, Nat Immunol, 4,, 69, 10.1038/ni875 Meager, 2005, Biological activity of interleukins-28 and -29: comparison with type I interferons, Cytokine, 31,, 109, 10.1016/j.cyto.2005.04.003 Khaitov, 2009, Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells, Allergy, 64,, 375, 10.1111/j.1398-9995.2008.01826.x Bochkov, 2010, Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma, Mucosal Immunol., 3,, 69, 10.1038/mi.2009.109 Proud, 2008, Gene expression profiles during in vivo human rhinovirus infection: insights into the host response, Am. J. Respir. Crit. Care Med., 178,, 962, 10.1164/rccm.200805-670OC Schoggins, 2011, A diverse range of gene products are effectors of the type I interferon antiviral response, Nature, 472,, 481, 10.1038/nature09907 Theofilopoulos, 2005, Type I interferons (alpha/beta) in immunity and autoimmunity, Annu. Rev. Immunol., 23,, 307, 10.1146/annurev.immunol.23.021704.115843 Lopez-Souza, 2009, In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects, J. Allergy Clin. Immunol., 123,, 1384, 10.1016/j.jaci.2009.03.010 Sykes, 2012, Rhinovirus 16-induced IFN-alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients, J. Allergy Clin. Immunol., 129,, 1506, 10.1016/j.jaci.2012.03.044 Gehlhar, 2006, Impaired virus-induced interferon-alpha2 release in adult asthmatic patients, Clin Exp Allergy, 36,, 331, 10.1111/j.1365-2222.2006.02450.x Bufe, 2002, Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release, Int. Arch Allergy Immunol., 127,, 82, 10.1159/000048173 Gill, 2010, Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells, J. Immunol., 184,, 5999, 10.4049/jimmunol.0901194 Cakebread, 2011, Exogenous IFN-beta has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus, J. Allergy Clin. Immunol., 127,, 1148, 10.1016/j.jaci.2011.01.023 McNamara, 2008, Comparison of techniques for obtaining lower airway epithelial cells from children, Eur. Respir. J., 32,, 763, 10.1183/09031936.00162507 Fonceca, 2012, Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection, Thorax, 67,, 42, 10.1136/thoraxjnl-2011-200131 Lopez-Guisa, 2012, Airway epithelial cells from asthmatic children differentially express proremodeling factors, J. Allergy Clin. Immunol., 129,, 990, 10.1016/j.jaci.2011.11.035 Vareille, 2012, Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells, Thorax, 67,, 517, 10.1136/thoraxjnl-2011-200405 Pizzichini, 1998, Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study, Am. J. Respir. Crit. Care. Med, 158,, 1178, 10.1164/ajrccm.158.4.9712082 Hewson, 2010, Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways, Eur. Respir. J., 36,, 1425, 10.1183/09031936.00026910 Laza-Stanca, 2011, The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations, PLoS Pathog., 7,, e1002114, 10.1371/journal.ppat.1002114 Koltsida, 2011, IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease, EMBO Mol. Med., 3,, 348, 10.1002/emmm.201100142 Wang, 2011, MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness, PLoS Pathog., 7,, e1002070, 10.1371/journal.ppat.1002070 Moffatt, 2010, A large-scale, consortium-based genomewide association study of asthma, N. Engl. J. Med., 363,, 1211, 10.1056/NEJMoa0906312 Moffatt, 2007, Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma, Nature, 448,, 470, 10.1038/nature06014 Gupta, 2011, Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma, Am. J. Respir. Crit. Care Med., 184,, 1342, 10.1164/rccm.201107-1239OC Bush, 2010, Management of severe asthma in children, Lancet, 376,, 814, 10.1016/S0140-6736(10)61054-9 Bracken, 2009, The importance of nurse-led home visits in the assessment of children with problematic asthma, Arch Dis. Child, 94,, 780, 10.1136/adc.2008.152140 Gielen, 2010, Azithromycin induces anti-viral responses in bronchial epithelial cells, Eur. Respir. J., 36,, 646, 10.1183/09031936.00095809 Johnston, 2005