The elusive function of metallothioneins

Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 15 - Trang 8428-8430 - 1998
Richard D. Palmiter1
1Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA

Tóm tắt

Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and consequences of genetic disruption and deliberate overexpression, the evolutionary forces that led to the initial appearance, gene duplications, and nearly ubiquitous expression of MTs remain enigmatic.

Từ khóa


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Proceedings of the National Academy of Sciences of the United States of America

Tập 95 Số 15

8428-8430

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