Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Nature Genetics - Tập 50 Số 1 - Trang 42-53 - 2018
Florence Démenais1,2, Patricia Margaritte‐Jeannin1,2, Kathleen C. Barnes3, William Cookson4, Janine Altmüller5, Wei Ang6, R. Graham Barr7, Terri H. Beaty8, Allan B. Becker9, John Beilby10, Hans Bisgaard11, Unnur Steina Björnsdóttir12, Eugene R. Bleecker13, Klaus Bønnelykke11, Dorret I. Boomsma14, Emmanuelle Bouzigon1,2, Christopher E. Brightling15, Myriam Brossard1,2, Guy Brusselle16,17,18, Esteban G. Burchard19, Kristin M. Burkart20, Andrew Bush21,22, Moira Chan‐Yeung23, Kian Fan Chung21, Alexessander Couto Alves24, John A. Curtin25, Adnan Čustović26, Denise Daley23, Johan C. de Jongste27, Blanca E. Del‐Rio‐Navarro28, Kathleen Donohue7, Liesbeth Duijts29, Celeste Eng30, Johan G. Eriksson31, Martin Farrall32,33, Yu. Yu. Fedorova34, Bjarke Feenstra35, Manuel A. R. Ferreira36, Maxim B. Freidin37, Zofia K. Z. Gajdos38, Jim Gauderman39, Ulrike Gehring40, Frank Geller35, Jon Genuneit41, Sina A. Gharib42, Frank D. Gilliland39, Raquel Granell43,44, Penelope E. Graves45, Daníel F. Guðbjartsson46,47, Tari Haahtela48, Susan R. Heckbert49, Dick Heederik40, Joachim Heinrich50,51, Markku Heliövaara52, John Henderson43,44, Blanca E. Himes53, Hiroshi Hirose54, Joel N. Hirschhorn55, Albert Hofman16, Patrick G. Holt56, Jouke‐Jan Hottenga14, Thomas J. Hudson57,58, Jennie Hui10, Medea Imboden59,60, В. П. Иванов61, Vincent W. V. Jaddoe62, Anthony James63,64, Christer Janson65, Marjo‐Riitta Järvelin66,67,68,69, Deborah Jarvis21, Graham Jones70, Ingileif Jónsdóttir47, Jari Lahti52, Michael Kabesch71, Mika Kähönen72, David B. Kantor73,74, А. С. Карунас34, Э. К. Хуснутдинова75,34, Gerard H. Koppelman76,77, Anita L. Kozyrskyj78, Eskil Kreiner11, Michiaki Kubo79, Rajesh Kumar80,81, Ashish Kumar59,60, Mikko Kuokkanen52, Lies Lahousse16, Tarja Laitinen82, Catherine Laprise83,84, Mark Lathrop85, Susanne Lau86, Young-Ae Lee87,88, Terho Lehtimäki89, Sébastien Letort1,2, Albert M. Levin90, Li Guo42, Liming Liang91, Laura R. Loehr92, Stephanie J. London93, Daan W. Loth16, Ani Manichaikul94, Ingo Marenholz87,88, Fernando J. Martínez45, Melanie C. Matheson95, Rasika A. Mathias96, Kenji Matsumoto97, Hamdi Mbarek14, Wendy L. McArdle98, Mads Melbye35, Erik Melén99, Deborah A. Meyers13, Sven Michel71, Hamida Mohamdi1,2, Arthur W. Musk100,101, Rachel A. Myers102, Maartje A. E. Nieuwenhuis76, Emiko Noguchi103, George O'connor104,105, Л. М. Огородова106, Cameron D. Palmer107, Aarno Palotie108, Julie E. Park23, Craig E. Pennell6, Göran Pershagen99, Alexey Polonikov61, Dirkje S. Postma76, Nicole Probst‐Hensch59,60, В. П. Пузырев37, Benjamin A. Raby109, Olli T. Raitakari110, Adaikalavan Ramasamy111, Stephen S. Rich94, Colin F. Robertson112, Isabelle Romieu113,114, Muhammad T. Salam115, Veikko Salomaa52, Vivi Schlünssen116, Robert A. Scott117, П. А. Селиванова118, Torben Sigsgaard116, Angela Simpson119, Valérie Siroux120,121, Lewis J. Smith122, Maria Solodilova61, Marie Standl51, Hreinn Stefánsson123, David P. Strachan124, Bruno H. Stricker125, Atsushi Takahashi79, Philip J. Thompson126, Guðmar Þorleifsson47, Unnur Þorsteinsdóttir123,47, Carla M. T. Tiesler127, Dara G. Torgerson30, Tatsuhiko Tsunoda79, André G. Uitterlinden128, Ralf J.P. van der Valk129, Amaury Vaysse1,2, Sailaja Vedantam55,38, Andrea von Berg130, Erika von Mutius131,132, Judith M. Vonk76, Johannes Waage11, Nicholas J. Wareham117, Scott T. Weiss109, Wendy White133, Magnus Wickman99, Elisabeth Widén108, Gonneke Willemsen14, L. Keoki Williams134,135, Inge M. Wouters40, James J. Yang136, Jing Hua Zhao117, Miriam F. Moffatt4, Carole Ober137, Dan L. Nicolae138
1Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
2Institut Universitaire d'Hématologie, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France
3Division of Biomedical Informatics and Personalized Medicine, Colorado Center for Personalized Medicine, University of Colorado, Denver, CO, USA
4Section of Genomic Medicine, National Heart and Lung Institute, London, UK
5Cologne Center for Genomics and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
6School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia
7Departments of Medicine and Epidemiology, Columbia University, New York, NY, USA
8Division of Genetic Epidemiology, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
9Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
10Department of the Diagnostic Genomics Laboratory, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia
11Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
12Department of Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland
13Center for Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA
14Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands
15University of Leicester, Institute for Lung Health, Glenfield Hospital, Leicester, UK
16Department of Epidemiology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands
17Department of Respiratory Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
18Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
19Department of Bioengineering & Therapeutic Sciences and Medicine, University of California, San Francisco, San Francisco, CA, USA
20Division of Pulmonary, Allergy and Critical Care, College of Physicians and Surgeons, Columbia University, New York, NY, USA
21National Heart and Lung Institute, Imperial College London, London, UK
22Royal Brompton Harefield National Health Service (NHS) Foundation Trust, London, UK
23Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
24Department of Epidemiology and Biostatistics, Imperial College London, London, UK
25Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
26Department of Paediatrics, Imperial College London, London, UK
27Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC–University Medical Center Rotterdam, Rotterdam, The Netherlands
28Hospital Infantil de Mexico “Federico Gomez”, Mexico City, Mexico
29Department of Pediatrics, Division of Respiratory Medicine, and Department of Pediatrics, Division of Neonatology, Erasmus MC–University Medical Center Rotterdam, Rotterdam, The Netherlands
30Department of Medicine, University of California San Francisco, San Francisco, CA, USA
31Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
32Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
33Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
34Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation
35Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
36Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
37Population Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russian Federation
38Divisions of Genetics and Endocrinology, Children's Hospital, Boston, MA, USA.
39Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
40Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
41Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
42Department of Medicine, University of Washington, Seattle, WA, USA.
43MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
44Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
45Asthma and Airway Disease Research Center and BIO5 Institute, University of Arizona, Tucson, AZ, USA
46School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
47deCODE genetics/Amgen, Inc., Reykjavik, Iceland
48Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland
49Department of Epidemiology, University of Washington, Seattle, WA, USA
50Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital in Munich, Munich, Germany
51Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany
52National Institute for Health and Welfare (THL), Helsinki, Finland
53Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA
54Health Center, Department of Internal Medicine, Keio University, Tokyo, Japan
55Broad Institute, Cambridge, MA, USA
56Cell Biology Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia
57AbbVie Inc, Redwood City, CA, USA
58Ontario Institute for Cancer Research, Toronto, Ontario, Canada
59Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
60University of Basel, Basel, Switzerland
61Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation
62The Generation R Study Group, Department of Pediatrics and Department of Epidemiology, Erasmus MC–University Medical Center Rotterdam, Rotterdam, The Netherlands
63Department of Pulmonary Physiology and Sleep Medicine, Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
64School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
65Department of Medical Sciences, Respiratory, Allergy & Sleep Research, Uppsala University, Uppsala, Sweden
66Biocenter Oulu, University of Oulu, Oulu, Finland
67Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
68Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK
69Unit of Primary Care, Oulu University Hospital, Oulu, Finland
70School of Science and Health, Western Sydney University, Sydney, New South Wales, Australia.
71Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO), Regensburg, Germany
72Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
73Department of Anaesthesia, Harvard Medical School, Boston, MA, USA
74Department of Anesthesiology, Perioperative and Pain Medicine, Division of Critical Care Medicine, Boston Children's Hospital, Boston, MA, USA
75Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation
76Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, The Netherlands
77University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen, The Netherlands
78Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
79RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
80Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA
81Divison of Allergy and Clinical Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
82Department of Pulmonary Medicine, University of Turku and Turku University Hospital, Turku, Finland
83Centre de Santé et de Services Sociaux du Saguenay-Lac-Saint-Jean, Saguenay, QC, Canada
84Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Quebec, Canada
85McGill University and Genome Quebec Innovation Centre, Montréal, QC, Canada
86Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany
87Max-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany
88Pediatric Allergology, Experimental and Clinical Research Center, Charité Universitätsmedizin, Berlin, Germany
89Department of Clinical Chemistry, Fimlab Laboratories, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
90Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA
91Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
92Division of General Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
93National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
94Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
95Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
96Division of Allergy & Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
97Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
98Bristol Bioresource Laboratories, School of Social and Community Medicine, University of Bristol, Bristol, UK
99Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
100Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
101Schools of Population Health and of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
102Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA
103Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
104Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
105The National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA, USA
106Department of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation
107Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA
108Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
109Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
110Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
111Department of Medical and Molecular Genetics, King’s College London, London, UK
112Respiratory Medicine, Murdoch Children's Research Institute, Melbourne, Victoria, Australia
113Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico
114Hubert Department of Global Health, Mory University, Atlanta, GA, USA
115Department of Psychiatry, Kern Medical, Bakersfield, CA, USA
116Department of Public Health, Section for Environment, Occupation & Health, Aarhus University, Aarhus, Denmark
117MRC Epidemiology Unit, University of Cambridge, School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
118Department of Faculty Therapy, Siberian State Medical University, Tomsk, Russian Federation
119University Hospital of South Manchester, National Health Service (NHS) Foundation Trust, Manchester, UK
120Institut National de la Santé et de la Recherche Médicale (INSERM) U1209, Institute for Advanced Biosciences, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
121Université de Grenoble Alpes/CNRS UMR5309, Institute for Advanced Biosciences, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
122Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
123Faculty of Medicine, University of Iceland, Reykjavik, Iceland
124Population Health Research Institute, St George's, University of London, London, UK
125Netherlands Healthcare Inspectorate, The Hague, The Netherlands
126Institute for Respiratory Health and Harry Perkins Institute of Medical Research, University of Western Australia and The Lung Health Clinic, Nedlands, Western Australia, Australia
127Division of Metabolic Diseases and Nutritional Medicine, Dr. Von Hauner Children’s Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany
128Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
129The Generation R Study Group, Department of Pediatrics, Division of Respiratory Medicine and Department of Epidemiology, Erasmus MC–University Medical Center Rotterdam, Rotterdam, The Netherlands
130Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany
131Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany
132German Center for Lung Research, Munich, Germany
133Undergraduate Training and Education Center (UTEC), Jackson Heart Study, Tougaloo College, Jackson, MI, USA
134Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, USA
135Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA
136School of Nursing, University of Michigan, Ann Arbor, MI, USA
137Department of Human Genetics, University of Chicago, Chicago, IL, USA
138Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA

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