The Emerging Hallmarks of Cancer Metabolism
Tài liệu tham khảo
Almuhaideb, 2011, 18F-FDG PET/CT imaging in oncology, Ann. Saudi Med., 31, 3, 10.4103/0256-4947.75771
Astuti, 2001, Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma, Am. J. Hum. Genet., 69, 49, 10.1086/321282
Balss, 2008, Analysis of the IDH1 codon 132 mutation in brain tumors, Acta Neuropathol., 116, 597, 10.1007/s00401-008-0455-2
Barthel, 1999, Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1, J. Biol. Chem., 274, 20281, 10.1074/jbc.274.29.20281
Bauer, 2005, ATP citrate lyase is an important component of cell growth and transformation, Oncogene, 24, 6314, 10.1038/sj.onc.1208773
Ben-Sahra, 2013, Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1, Science, 339, 1323, 10.1126/science.1228792
Benz, 2011, (18)F-FDG PET/CT for monitoring treatment responses to the epidermal growth factor receptor inhibitor erlotinib, J. Nucl. Med., 52, 1684, 10.2967/jnumed.111.095257
Bertout, 2008, The impact of O2 availability on human cancer, Nat. Rev. Cancer, 8, 967, 10.1038/nrc2540
Berwick, 2002, The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes, J. Biol. Chem., 277, 33895, 10.1074/jbc.M204681200
Birsoy, 2015, An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis, Cell, 162, 540, 10.1016/j.cell.2015.07.016
Blaschke, 2013, Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells, Nature, 500, 222, 10.1038/nature12362
Borger, 2012, Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping, Oncologist, 17, 72, 10.1634/theoncologist.2011-0386
Bowles, 2008, Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase, Int. J. Cancer, 123, 1950, 10.1002/ijc.23723
Boxer, 2006, Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation, Cell Metab., 4, 475, 10.1016/j.cmet.2006.10.011
Boya, 2013, Emerging regulation and functions of autophagy, Nat. Cell Biol., 15, 713, 10.1038/ncb2788
Brady, 2014, Copper is required for oncogenic BRAF signalling and tumorigenesis, Nature, 509, 492, 10.1038/nature13180
Brand, 1986, Metabolic alterations associated with proliferation of mitogen-activated lymphocytes and of lymphoblastoid cell lines: evaluation of glucose and glutamine metabolism, Immunobiology, 173, 23, 10.1016/S0171-2985(86)80086-9
Cai, 2011, Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes, Mol. Cell, 42, 426, 10.1016/j.molcel.2011.05.004
Carey, 2015, Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells, Nature, 518, 413, 10.1038/nature13981
Carmona-Fontaine, 2013, Emergence of spatial structure in the tumor microenvironment due to the Warburg effect, Proc. Natl. Acad. Sci. USA, 110, 19402, 10.1073/pnas.1311939110
Casero, 2007, Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases, Nat. Rev. Drug Discov., 6, 373, 10.1038/nrd2243
Cavalli, 1997, Diminished tumorigenic phenotype after depletion of mitochondrial DNA, Cell Growth Differ., 8, 1189
Chajès, 2006, Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival, Cancer Res., 66, 5287, 10.1158/0008-5472.CAN-05-1489
Chambers, 2010, Glutamine metabolism is essential for human cytomegalovirus infection, J. Virol., 84, 1867, 10.1128/JVI.02123-09
Chaneton, 2012, Serine is a natural ligand and allosteric activator of pyruvate kinase M2, Nature, 491, 458, 10.1038/nature11540
Chen, 2007, Lysine propionylation and butyrylation are novel post-translational modifications in histones, Mol. Cell. Proteomics, 6, 812, 10.1074/mcp.M700021-MCP200
Cheng, 2011, Pyruvate carboxylase is required for glutamine-independent growth of tumor cells, Proc. Natl. Acad. Sci. USA, 108, 8674, 10.1073/pnas.1016627108
Chiang, 2009, Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation, J. Clin. Endocrinol. Metab., 94, 1017, 10.1210/jc.2008-2038
Choi, 2012, 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas, Nat. Med., 18, 624, 10.1038/nm.2682
Chowdhury, 2005, High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines, Biochem. Biophys. Res. Commun., 333, 1139, 10.1016/j.bbrc.2005.06.017
Christofk, 2008, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, Nature, 452, 230, 10.1038/nature06734
Christofk, 2008, Pyruvate kinase M2 is a phosphotyrosine-binding protein, Nature, 452, 181, 10.1038/nature06667
Cohen, 2013, IDH1 and IDH2 mutations in gliomas, Curr. Neurol. Neurosci. Rep., 13, 345, 10.1007/s11910-013-0345-4
Colegio, 2014, Functional polarization of tumour-associated macrophages by tumour-derived lactic acid, Nature, 513, 559, 10.1038/nature13490
Collins, 1998, Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines, J. Cell. Physiol., 176, 166, 10.1002/(SICI)1097-4652(199807)176:1<166::AID-JCP18>3.0.CO;2-5
Comerford, 2014, Acetate dependence of tumors, Cell, 159, 1591, 10.1016/j.cell.2014.11.020
Commisso, 2013, Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells, Nature, 497, 633, 10.1038/nature12138
Conrad, 2012, The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-): cystine supplier and beyond, Amino Acids, 42, 231, 10.1007/s00726-011-0867-5
Constant, 2000, Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia, Wound Repair Regen., 8, 353, 10.1111/j.1524-475X.2000.00353.x
Courtois-Cox, 2008, Many roads lead to oncogene-induced senescence, Oncogene, 27, 2801, 10.1038/sj.onc.1210950
Cunningham, 2014, Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer, Cell, 157, 1088, 10.1016/j.cell.2014.03.052
Dang, 2010, Cancer-associated IDH1 mutations produce 2-hydroxyglutarate, Nature, 465, 966, 10.1038/nature09132
DeBerardinis, 2007, Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc. Natl. Acad. Sci. USA, 104, 19345, 10.1073/pnas.0709747104
Delage, 2010, Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer, Int. J. Cancer, 126, 2762
Denu, 1998, Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation, Biochemistry, 37, 5633, 10.1021/bi973035t
Deprez, 1997, Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades, J. Biol. Chem., 272, 17269, 10.1074/jbc.272.28.17269
Donald, 2001, Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species, Cancer Res., 61, 1810
Du, 2009, Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model, BMC Cancer, 9, 261, 10.1186/1471-2407-9-261
Durán, 2012, Glutaminolysis activates Rag-mTORC1 signaling, Mol. Cell, 47, 349, 10.1016/j.molcel.2012.05.043
Eagle, 1955, The minimum vitamin requirements of the L and HeLa cells in tissue culture, the production of specific vitamin deficiencies, and their cure, J. Exp. Med., 102, 595, 10.1084/jem.102.5.595
Eberhardy, 2001, c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism, J. Biol. Chem., 276, 48562, 10.1074/jbc.M109014200
Ensor, 2002, Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo, Cancer Res., 62, 5443
Fallarino, 2002, T cell apoptosis by tryptophan catabolism, Cell Death Differ., 9, 1069, 10.1038/sj.cdd.4401073
Fallarino, 2006, The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells, J. Immunol., 176, 6752, 10.4049/jimmunol.176.11.6752
Fan, 2014, Quantitative flux analysis reveals folate-dependent NADPH production, Nature, 510, 298, 10.1038/nature13236
Figueroa, 2010, Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, 18, 553, 10.1016/j.ccr.2010.11.015
Fischer, 2007, Inhibitory effect of tumor cell-derived lactic acid on human T cells, Blood, 109, 3812, 10.1182/blood-2006-07-035972
Flavin, 2010, Fatty acid synthase as a potential therapeutic target in cancer, Future Oncol., 6, 551, 10.2217/fon.10.11
Fontenelle, 1969, Sources of nitrogen as rate-limiting factors for purine biosynthesis de novo in Ehrlich ascites tumor cells, Biochim. Biophys. Acta, 177, 88, 10.1016/0304-4165(69)90067-1
Freed-Pastor, 2012, Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway, Cell, 148, 244, 10.1016/j.cell.2011.12.017
Gaglio, 2009, Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts, PLoS ONE, 4, e4715, 10.1371/journal.pone.0004715
Gao, 2009, c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism, Nature, 458, 762, 10.1038/nature07823
Garrett, 2015, Cancer and the microbiota, Science, 348, 80, 10.1126/science.aaa4972
Gerner, 2004, Polyamines and cancer: old molecules, new understanding, Nat. Rev. Cancer, 4, 781, 10.1038/nrc1454
Goetze, 2011, Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release, Int. J. Oncol., 39, 453
Gottfried, 2006, Tumor-derived lactic acid modulates dendritic cell activation and antigen expression, Blood, 107, 2013, 10.1182/blood-2005-05-1795
Gottlob, 2001, Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase, Genes Dev., 15, 1406, 10.1101/gad.889901
Grassian, 2011, Extracellular matrix regulation of metabolism and implications for tumorigenesis, Cold Spring Harb. Symp. Quant. Biol., 76, 313, 10.1101/sqb.2011.76.010967
Graves, 2000, Regulation of carbamoyl phosphate synthetase by MAP kinase, Nature, 403, 328, 10.1038/35002111
Guo, 2013, Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis, Genes Dev., 27, 1447, 10.1101/gad.219642.113
Gupte, 2009, Elevated copper and oxidative stress in cancer cells as a target for cancer treatment, Cancer Treat. Rev., 35, 32, 10.1016/j.ctrv.2008.07.004
Hanahan, 2012, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Cancer Cell, 21, 309, 10.1016/j.ccr.2012.02.022
Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9
Hill, 1967, L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia, JAMA, 202, 882, 10.1001/jama.1967.03130220070012
Hino, 2012, FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure, Nat. Commun., 3, 758, 10.1038/ncomms1755
Hirata, 2015, Mutant IDH is sufficient to initiate enchondromatosis in mice, Proc. Natl. Acad. Sci. USA, 112, 2829, 10.1073/pnas.1424400112
Imai, 2000, Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase, Nature, 403, 795, 10.1038/35001622
Intlekofer, 2015, Hypoxia induces production of L-2-hydroxyglutarate, Cell Metab., 22, 304, 10.1016/j.cmet.2015.06.023
Itkonen, 2013, O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells, Cancer Res., 73, 5277, 10.1158/0008-5472.CAN-13-0549
Janeway, 2011, Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations, Proc. Natl. Acad. Sci. USA, 108, 314, 10.1073/pnas.1009199108
Jewell, 2015, Metabolism. Differential regulation of mTORC1 by leucine and glutamine, Science, 347, 194, 10.1126/science.1259472
Jiang, 2011, p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase, Nat. Cell Biol., 13, 310, 10.1038/ncb2172
Kamata, 2005, Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases, Cell, 120, 649, 10.1016/j.cell.2004.12.041
Kamphorst, 2013, Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids, Proc. Natl. Acad. Sci. USA, 110, 8882, 10.1073/pnas.1307237110
Kamphorst, 2015, Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein, Cancer Res., 75, 544, 10.1158/0008-5472.CAN-14-2211
Kaplon, 2013, A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence, Nature, 498, 109, 10.1038/nature12154
Katada, 2012, Connecting threads: epigenetics and metabolism, Cell, 148, 24, 10.1016/j.cell.2012.01.001
Keller, 2012, SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions, Science, 338, 1069, 10.1126/science.1224409
Kerr, 2009, Defining macropinocytosis, Traffic, 10, 364, 10.1111/j.1600-0854.2009.00878.x
Killian, 2013, Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor, Cancer Discov., 3, 648, 10.1158/2159-8290.CD-13-0092
Kim, 2006, HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia, Cell Metab., 3, 177, 10.1016/j.cmet.2006.02.002
Kollareddy, 2015, Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities, Nat. Commun., 6, 7389, 10.1038/ncomms8389
Krajcovic, 2013, mTOR regulates phagosome and entotic vacuole fission, Mol. Biol. Cell, 24, 3736, 10.1091/mbc.E13-07-0408
Krause, 2013, Imaging of prostate cancer with PET/CT and radioactively labeled choline derivates, Urol. Oncol., 31, 427, 10.1016/j.urolonc.2010.08.008
Kuemmerle, 2011, Lipoprotein lipase links dietary fat to solid tumor cell proliferation, Mol. Cancer Ther., 10, 427, 10.1158/1535-7163.MCT-10-0802
Kung, 2011, Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia, PLoS Genet., 7, e1002229, 10.1371/journal.pgen.1002229
Kwee, 2007, Cancer imaging with fluorine-18-labeled choline derivatives, Semin. Nucl. Med., 37, 420, 10.1053/j.semnuclmed.2007.07.003
LeBleu, 2014, PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis, Nat. Cell Biol., 16, 992, 10.1038/ncb3039
Lee, 2002, Reversible inactivation of the tumor suppressor PTEN by H2O2, J. Biol. Chem., 277, 20336, 10.1074/jbc.M111899200
Lee, 2014, Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation, Cell Metab., 20, 306, 10.1016/j.cmet.2014.06.004
Letouzé, 2013, SDH mutations establish a hypermethylator phenotype in paraganglioma, Cancer Cell, 23, 739, 10.1016/j.ccr.2013.04.018
Lheureux, 2013, (18)F-FDG is a surrogate marker of therapy response and tumor recovery after drug withdrawal during treatment with a dual PI3K/mTOR inhibitor in a preclinical model of cisplatin-resistant ovarian cancer, Transl. Oncol., 6, 586, 10.1593/tlo.13100
Li, 2014, Direct visualization of de novo lipogenesis in single living cells, Sci. Rep., 4, 6807, 10.1038/srep06807
Lieberman, 2011, PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine, J. Nucl. Med., 52, 1947, 10.2967/jnumed.111.093815
Lindsten, 2003, The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool, J. Neurosci., 23, 11112, 10.1523/JNEUROSCI.23-35-11112.2003
Liu, 2008, Global regulation of nucleotide biosynthetic genes by c-Myc, PLoS ONE, 3, e2722, 10.1371/journal.pone.0002722
Liu, 2009, Proline oxidase functions as a mitochondrial tumor suppressor in human cancers, Cancer Res., 69, 6414, 10.1158/0008-5472.CAN-09-1223
Liu, 2012, Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC, Proc. Natl. Acad. Sci. USA, 109, 8983, 10.1073/pnas.1203244109
Lo, 2008, The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases, J. Cell. Physiol., 215, 593, 10.1002/jcp.21366
Locasale, 2011, Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis, Nat. Genet., 43, 869, 10.1038/ng.890
Losman, 2013, (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible, Science, 339, 1621, 10.1126/science.1231677
Lu, 2012, IDH mutation impairs histone demethylation and results in a block to cell differentiation, Nature, 483, 474, 10.1038/nature10860
Lu, 2013, Induction of sarcomas by mutant IDH2, Genes Dev., 27, 1986, 10.1101/gad.226753.113
Lum, 2005, Growth factor regulation of autophagy and cell survival in the absence of apoptosis, Cell, 120, 237, 10.1016/j.cell.2004.11.046
Lunt, 2011, Aerobic glycolysis: meeting the metabolic requirements of cell proliferation, Annu. Rev. Cell Dev. Biol., 27, 441, 10.1146/annurev-cellbio-092910-154237
Ma, 2009, [18F]fluorodeoxyglucose positron emission tomography correlates with Akt pathway activity but is not predictive of clinical outcome during mTOR inhibitor therapy, J. Clin. Oncol., 27, 2697, 10.1200/JCO.2008.18.8383
MacDonald, 1990, High activity of mitochondrial glycerol phosphate dehydrogenase in insulinomas and carcinoid and other tumors of the amine precursor uptake decarboxylation system, Cancer Res., 50, 7203
MacKenzie, 2007, Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells, Mol. Cell. Biol., 27, 3282, 10.1128/MCB.01927-06
Maddocks, 2013, Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells, Nature, 493, 542, 10.1038/nature11743
Maher, 2012, Metabolism of [U-13 C]glucose in human brain tumors in vivo, NMR Biomed., 25, 1234, 10.1002/nbm.2794
Mannava, 2008, Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells, Cell Cycle, 7, 2392, 10.4161/cc.6390
Mardis, 2009, Recurring mutations found by sequencing an acute myeloid leukemia genome, N. Engl. J. Med., 361, 1058, 10.1056/NEJMoa0903840
Marin-Valencia, 2012, Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo, Cell Metab., 15, 827, 10.1016/j.cmet.2012.05.001
Márquez, 1989, Nitrogen metabolism in tumor bearing mice, Arch. Biochem. Biophys., 268, 667, 10.1016/0003-9861(89)90335-4
Martínez-Zaguilán, 1996, Acidic pH enhances the invasive behavior of human melanoma cells, Clin. Exp. Metastasis, 14, 176, 10.1007/BF00121214
Mashimo, 2014, Acetate is a bioenergetic substrate for human glioblastoma and brain metastases, Cell, 159, 1603, 10.1016/j.cell.2014.11.025
McAlpine, 2014, Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy, BMC Cancer, 14, 621, 10.1186/1471-2407-14-621
Mehedint, 2010, Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene, FASEB J., 24, 184, 10.1096/fj.09-140145
Menendez, 2007, Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nat. Rev. Cancer, 7, 763, 10.1038/nrc2222
Metallo, 2012, Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia, Nature, 481, 380, 10.1038/nature10602
Migita, 2008, ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer, Cancer Res., 68, 8547, 10.1158/0008-5472.CAN-08-1235
Milgraum, 1997, Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma, Clin. Cancer Res., 3, 2115
Minor, 2013, Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine, J. Biol. Chem., 288, 13669, 10.1074/jbc.C113.464800
Morais, 1994, Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA, Cancer Res., 54, 3889
Munn, 2007, Indoleamine 2,3-dioxygenase and tumor-induced tolerance, J. Clin. Invest., 117, 1147, 10.1172/JCI31178
Murakami, 1992, Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes, J. Biol. Chem., 267, 9300, 10.1016/S0021-9258(19)50423-9
Nicholson, 2009, Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer, Int. J. Cancer, 125, 1454, 10.1002/ijc.24546
Nicklin, 2009, Bidirectional transport of amino acids regulates mTOR and autophagy, Cell, 136, 521, 10.1016/j.cell.2008.11.044
Niculescu, 2006, Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains, FASEB J., 20, 43, 10.1096/fj.05-4707com
Nieman, 2011, Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth, Nat. Med., 17, 1498, 10.1038/nm.2492
Nilsson, 2014, Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer, Nat. Commun., 5, 3128, 10.1038/ncomms4128
Noch, 2012, Oncogenic viruses and tumor glucose metabolism: like kids in a candy store, Mol. Cancer Ther., 11, 14, 10.1158/1535-7163.MCT-11-0517
Noguchi, 1986, The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing, J. Biol. Chem., 261, 13807, 10.1016/S0021-9258(18)67091-7
Nomura, 2010, Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis, Cell, 140, 49, 10.1016/j.cell.2009.11.027
Oldham, 2015, Hypoxia-mediated increases in l-2-hydroxyglutarate coordinate the metabolic response to reductive stress, Cell Metab., 22, 291, 10.1016/j.cmet.2015.06.021
Opitz, 2011, An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor, Nature, 478, 197, 10.1038/nature10491
Osada, 2000, Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma, J. Hepatol., 33, 247, 10.1016/S0168-8278(00)80365-7
Palm, 2015, The utilization of extracellular proteins as nutrients is suppressed by mTORC1, Cell, 162, 259, 10.1016/j.cell.2015.06.017
Papandreou, 2006, HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption, Cell Metab., 3, 187, 10.1016/j.cmet.2006.01.012
Parsons, 2008, An integrated genomic analysis of human glioblastoma multiforme, Science, 321, 1807, 10.1126/science.1164382
Paschka, 2010, IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication, J. Clin. Oncol., 28, 3636, 10.1200/JCO.2010.28.3762
Pate, 2014, Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer, EMBO J., 33, 1454, 10.15252/embj.201488598
Phang, 2008, The metabolism of proline, a stress substrate, modulates carcinogenic pathways, Amino Acids, 35, 681, 10.1007/s00726-008-0063-4
Pieters, 2011, L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase, Cancer, 117, 238, 10.1002/cncr.25489
Plas, 2001, Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology, J. Biol. Chem., 276, 12041, 10.1074/jbc.M010551200
Possemato, 2011, Functional genomics reveal that the serine synthesis pathway is essential in breast cancer, Nature, 476, 346, 10.1038/nature10350
Rathmell, 2000, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability, Mol. Cell, 6, 683, 10.1016/S1097-2765(00)00066-6
Rathmell, 2003, Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival, Mol. Cell. Biol., 23, 7315, 10.1128/MCB.23.20.7315-7328.2003
Reynolds, 2014, Control of glutamine metabolism by the tumor suppressor Rb, Oncogene, 33, 556, 10.1038/onc.2012.635
Richman, 2012, Choline intake and risk of lethal prostate cancer: incidence and survival, Am. J. Clin. Nutr., 96, 855, 10.3945/ajcn.112.039784
Rivera, 1988, Amino acid metabolism in tumour-bearing mice, Biochem. J., 249, 443, 10.1042/bj2490443
Roberts, 1949, Free amino acids in normal and neoplastic tissues of mice as studied by paper chromatography, Cancer Res., 9, 645
Robitaille, 2013, Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis, Science, 339, 1320, 10.1126/science.1228771
Rohle, 2013, An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells, Science, 340, 626, 10.1126/science.1236062
Rothberg, 2013, Acid-mediated tumor proteolysis: contribution of cysteine cathepsins, Neoplasia, 15, 1125, 10.1593/neo.13946
Rysman, 2010, De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation, Cancer Res., 70, 8117, 10.1158/0008-5472.CAN-09-3871
Sabari, 2015, Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation, Mol. Cell, 58, 203, 10.1016/j.molcel.2015.02.029
Sasaki, 2012, IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics, Nature, 488, 656, 10.1038/nature11323
Sauer, 1982, Amino acid, glucose, and lactic acid utilization in vivo by rat tumors, Cancer Res., 42, 4090
Schafer, 2009, Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment, Nature, 461, 109, 10.1038/nature08268
Schmid, 2007, Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1, Exp. Cell Res., 313, 2531, 10.1016/j.yexcr.2007.05.016
Schug, 2015, Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress, Cancer Cell, 27, 57, 10.1016/j.ccell.2014.12.002
Schwer, 2008, Conserved metabolic regulatory functions of sirtuins, Cell Metab., 7, 104, 10.1016/j.cmet.2007.11.006
Selak, 2005, Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase, Cancer Cell, 7, 77, 10.1016/j.ccr.2004.11.022
Sellers, 2015, Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation, J. Clin. Invest., 125, 687, 10.1172/JCI72873
Shi, 2013, Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae, Proc. Natl. Acad. Sci. USA, 110, 7318, 10.1073/pnas.1302490110
Shi, 2004, Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Cell, 119, 941, 10.1016/j.cell.2004.12.012
Shim, 2014, L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer, Cancer Discov., 4, 1290, 10.1158/2159-8290.CD-13-0696
Shyh-Chang, 2013, Influence of threonine metabolism on S-adenosylmethionine and histone methylation, Science, 339, 222, 10.1126/science.1226603
Sircar, 2012, Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer, Am. J. Pathol., 180, 895, 10.1016/j.ajpath.2011.11.030
Som, 1980, A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection, J. Nucl. Med., 21, 670
Son, 2013, Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway, Nature, 496, 101, 10.1038/nature12040
Sonveaux, 2012, Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis, PLoS ONE, 7, e33418, 10.1371/journal.pone.0033418
Spiro, 2002, Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds, Glycobiology, 12, 43R, 10.1093/glycob/12.4.43R
Sporn, 2012, NRF2 and cancer: the good, the bad and the importance of context, Nat. Rev. Cancer, 12, 564, 10.1038/nrc3278
Stern, 2002, Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited, Exp. Cell Res., 276, 24, 10.1006/excr.2002.5508
Stolzing, 2004, Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells, FASEB J., 18, 743, 10.1096/fj.03-0374fje
Strohecker, 2013, Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors, Cancer Discov., 3, 1272, 10.1158/2159-8290.CD-13-0397
Sullivan, 2014, Mitochondrial reactive oxygen species and cancer, Cancer Metab., 2, 17, 10.1186/2049-3002-2-17
Sullivan, 2015, Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells, Cell, 162, 552, 10.1016/j.cell.2015.07.017
Sun, 2014, Competition between human cells by entosis, Cell Res., 24, 1299, 10.1038/cr.2014.138
Svastová, 2004, Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH, FEBS Lett., 577, 439, 10.1016/j.febslet.2004.10.043
Swietach, 2007, Regulation of tumor pH and the role of carbonic anhydrase 9, Cancer Metastasis Rev., 26, 299, 10.1007/s10555-007-9064-0
Tan, 2015, Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA, Cell Metab., 21, 81, 10.1016/j.cmet.2014.12.003
Terunuma, 2014, MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis, J. Clin. Invest., 124, 398, 10.1172/JCI71180
Thompson, 2011, Rethinking the regulation of cellular metabolism, Cold Spring Harb. Symp. Quant. Biol., 76, 23, 10.1101/sqb.2012.76.010496
Tibbetts, 2010, Compartmentalization of Mammalian folate-mediated one-carbon metabolism, Annu. Rev. Nutr., 30, 57, 10.1146/annurev.nutr.012809.104810
Tomlinson, 2002, Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer, Nat. Genet., 30, 406, 10.1038/ng849
Towbin, 2012, Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery, Cell, 150, 934, 10.1016/j.cell.2012.06.051
Turcan, 2012, IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype, Nature, 483, 479, 10.1038/nature10866
Vacchelli, 2014, Trial watch: IDO inhibitors in cancer therapy, OncoImmunology, 3, e957994, 10.4161/21624011.2014.957994
Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Vaupel, 1989, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review, Cancer Res., 49, 6449
Végran, 2011, Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis, Cancer Res., 71, 2550, 10.1158/0008-5472.CAN-10-2828
Venneti, 2015, Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo, Sci. Transl. Med., 7, 274ra17, 10.1126/scitranslmed.aaa1009
Viale, 2014, Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function, Nature, 514, 628, 10.1038/nature13611
Vogelstein, 2004, Cancer genes and the pathways they control, Nat. Med., 10, 789, 10.1038/nm1087
Wahlström, 2015, Impact of MYC in regulation of tumor cell metabolism, Biochim. Biophys. Acta, 1849, 563, 10.1016/j.bbagrm.2014.07.004
Wang, 2011, Identification of transaldolase as a novel serum biomarker for hepatocellular carcinoma metastasis using xenografted mouse model and clinic samples, Cancer Lett., 313, 154, 10.1016/j.canlet.2011.08.031
Wang, 2011, The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation, Immunity, 35, 871, 10.1016/j.immuni.2011.09.021
Wang, 2013, Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation, Science, 340, 622, 10.1126/science.1234769
Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309
Warburg, 1924, Über den Stoffwechsel der Carcinomzelle, Biochem Zeitschr, 152, 309
Warburg, 1927, The metabolism of tumors in the body, J. Gen. Physiol., 8, 519, 10.1085/jgp.8.6.519
Ward, 2010, The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate, Cancer Cell, 17, 225, 10.1016/j.ccr.2010.01.020
Wellen, 2009, ATP-citrate lyase links cellular metabolism to histone acetylation, Science, 324, 1076, 10.1126/science.1164097
Wellen, 2010, The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism, Genes Dev., 24, 2784, 10.1101/gad.1985910
Wieman, 2007, Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking, Mol. Biol. Cell, 18, 1437, 10.1091/mbc.E06-07-0593
Wise, 2008, Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction, Proc. Natl. Acad. Sci. USA, 105, 18782, 10.1073/pnas.0810199105
Wise, 2011, Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability, Proc. Natl. Acad. Sci. USA, 108, 19611, 10.1073/pnas.1117773108
Wisniewski, 2008, Nepsilon-formylation of lysine is a widespread post-translational modification of nuclear proteins occurring at residues involved in regulation of chromatin function, Nucleic Acids Res., 36, 570, 10.1093/nar/gkm1057
Wu, 2015, Hydrogen sulfide in cancer: friend or foe?, Nitric Oxide, 50, 38, 10.1016/j.niox.2015.08.004
Xiao, 2012, Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors, Genes Dev., 26, 1326, 10.1101/gad.191056.112
Xie, 2012, Lysine succinylation and lysine malonylation in histones, Mol. Cell. Proteomics, 11, 100, 10.1074/mcp.M111.015875
Xu, 2009, High intakes of choline and betaine reduce breast cancer mortality in a population-based study, FASEB J., 23, 4022, 10.1096/fj.09-136507
Xu, 2009, Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells, Int. J. Cancer, 124, 1330, 10.1002/ijc.24078
Xu, 2011, Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases, Cancer Cell, 19, 17, 10.1016/j.ccr.2010.12.014
Yan, 1996, Regulation of Src family tyrosine kinase activities in adherent human neutrophils. Evidence that reactive oxygen intermediates produced by adherent neutrophils increase the activity of the p58c-fgr and p53/56lyn tyrosine kinases, J. Biol. Chem., 271, 23464, 10.1074/jbc.271.38.23464
Yanagida, 2001, Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines, Biochim. Biophys. Acta, 1514, 291, 10.1016/S0005-2736(01)00384-4
Ye, 2012, Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation, Proc. Natl. Acad. Sci. USA, 109, 6904, 10.1073/pnas.1204176109
Ye, 2014, Serine catabolism regulates mitochondrial redox control during hypoxia, Cancer Discov., 4, 1406, 10.1158/2159-8290.CD-14-0250
Ying, 2012, Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism, Cell, 149, 656, 10.1016/j.cell.2012.01.058
Ying, 2013, Associations between dietary intake of choline and betaine and lung cancer risk, PLoS ONE, 8, e54561, 10.1371/journal.pone.0054561
Yoon, 2007, Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase, Int. J. Cancer, 120, 897, 10.1002/ijc.22322
Young, 2013, Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress, Genes Dev., 27, 1115, 10.1101/gad.198630.112
Yuneva, 2007, Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells, J. Cell Biol., 178, 93, 10.1083/jcb.200703099
Yuneva, 2012, The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type, Cell Metab., 15, 157, 10.1016/j.cmet.2011.12.015
Zhang, 2013, Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China, Cancer Sci., 104, 250, 10.1111/cas.12064
Zhang, 2014, Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion, Mol. Cell, 56, 205, 10.1016/j.molcel.2014.08.018
