Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

Armstrong, 2002, Insights from protein film voltammetry into mechanisms of complex biological electron-transfer reactions, J. Chem. Soc., Dalton Trans., 5, 661, 10.1039/b108359g

Balaban, 2005, Cell, 120, 483, 10.1016/j.cell.2005.02.001

Becker, 2004, New concepts in reactive oxygen species and cardiovascular reperfusion physiology, Cardiovasc. Res., 61, 461, 10.1016/j.cardiores.2003.10.025

Bernardi, 1981, Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes, J. Biol. Chem., 256, 7187, 10.1016/S0021-9258(19)68946-5

Bernardi, 2001, A mitochondrial perspective on cell death, Trends Biochem. Sci., 26, 112, 10.1016/S0968-0004(00)01745-X

Brownlee, 2001, Biochemistry and molecular cell biology of diabetic complications, Nature, 414, 813, 10.1038/414813a

Cai, 1998, Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss, J. Biol. Chem., 273, 11401, 10.1074/jbc.273.19.11401

Callegari, 2004, Functionalised single wall carbon nanotubes/polypyrrole composites for the preparation of amperometric glucose biosensors, J. Mat. Chem., 14, 807, 10.1039/B316806A

Chance, 1979, Hydroperoxide metabolism in mammalian organs, Physiol. Rev., 59, 527, 10.1152/physrev.1979.59.3.527

Chen, 2002, Redox properties of cytochrome c adsorbed on self-assembled monolayers: a probe for protein conformation and orientation, Langmuir, 18, 7009, 10.1021/la0204794

Danial, 2004, Cell death: critical control points, Cell, 116, 205, 10.1016/S0092-8674(04)00046-7

Diwan, 1988, Enhanced uptake of spermidine and methylglyoxal-bis(guanylhydrazone) by rat liver mitochondria following outer membrane lysis, Biochem. Pharmacol., 37, 957, 10.1016/0006-2952(88)90188-8

Francia, 2004, Deletion of p66shc gene protects against age-related endothelial dysfunction, Circulation, 110, 2889, 10.1161/01.CIR.0000147731.24444.4D

Green, 2004, The pathophysiology of mitochondrial cell death, Science, 305, 626, 10.1126/science.1099320

Griparic, 2004, Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria, J. Biol. Chem., 279, 18792, 10.1074/jbc.M400920200

LeBel, 1992, Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chem. Res. Toxicol., 5, 227, 10.1021/tx00026a012

Mayer, 1994, N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro, Proc. Natl. Acad. Sci. USA, 91, 7496, 10.1073/pnas.91.16.7496

Migliaccio, 1997, Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase fos signalling pathway, EMBO J., 16, 706, 10.1093/emboj/16.4.706

Migliaccio, 1999, The p66shc adaptor protein controls oxidative stress response and life span in mammals, Nature, 402, 309, 10.1038/46311

Napoli, 2003, Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet, Proc. Natl. Acad. Sci. USA, 18, 2112, 10.1073/pnas.0336359100

Nemoto, 2002, Redox regulation of forkhead proteins through a p66shc dependent signaling pathway, Science, 295, 2450, 10.1126/science.1069004

Orsini, 2004, The lifespan determinant p66Shc localizes to mitochondria where it associates with mtHsp70 and regulates trans-membrane potential, J. Biol. Chem., 11, 25689, 10.1074/jbc.M401844200

Pacini, 2004, P66Shc promotes apoptosis and antagonizes mitogenic signaling in T cells, Mol. Cell. Biol., 24, 1747, 10.1128/MCB.24.4.1747-1757.2004

Pelicci, 2004, Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?, J. Clin. Invest., 113, 4, 10.1172/JCI200420750

Pelicci, 1992, A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction, Cell, 70, 93, 10.1016/0092-8674(92)90536-L

Petronilli, 1994, The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents, J. Biol. Chem., 269, 16638, 10.1016/S0021-9258(19)89437-1

Sakon, 2003, NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death, EMBO J., 22, 3898, 10.1093/emboj/cdg379

Sarti, 2003, Nitric oxide and mitochondrial complex IV, IUBMB Life, 55, 605, 10.1080/15216540310001628726

Scorrano, 2002, A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis, Dev. Cell, 2, 55, 10.1016/S1534-5807(01)00116-2

Scorrano, 2003, Mechanisms of cytochrome c release by proapoptotic BCL-2 family members, Biochem. Biophys. Res. Commun., 304, 437, 10.1016/S0006-291X(03)00615-6

Trinei, 2002, A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis, Oncogene, 21, 3872, 10.1038/sj.onc.1205513

Ventura, 2004, A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria, J. Biol. Chem., 279, 2299, 10.1074/jbc.M307655200

Wallace, 1999, Mitochondrial diseases in man and mouse, Science, 283, 1482, 10.1126/science.283.5407.1482

Zaccagnini, 2004, P66ShcA modulates tissue response to hindlimb ischemia, Circulation, 109, 2917, 10.1161/01.CIR.0000129309.58874.0F

Zhao, 2003, Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide, Free Radic. Biol. Med., 34, 1359, 10.1016/S0891-5849(03)00142-4

Zhen, 1999, Definition of the interaction domain for cytochrome c on cytochrome c oxidase. I. Biochemical, spectral, and kinetic characterization of surface mutants in subunit ii of Rhodobacter sphaeroides cytochrome aa(3), J. Biol. Chem., 274, 38032, 10.1074/jbc.274.53.38032