Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Cell - Tập 139 - Trang 485-498 - 2009
Ivaylo I. Ivanov1, Koji Atarashi2, Nicolas Manel1, Eoin L. Brodie3, Tatsuichiro Shima4, Ulas Karaoz3, Dongguang Wei5, Katherine C. Goldfarb3, Clark A. Santee3, Susan V. Lynch6, Takeshi Tanoue2, Akemi Imaoka4, Kikuji Itoh7, Kiyoshi Takeda2, Yoshinori Umesaki4, Kenya Honda2,8, Dan R. Littman1,9
1Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
2Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
3Center for Environmental Biotechnology, Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
4Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan
5Carl Zeiss SMT, Inc., Nanotechnology Systems Division, One Corporation Way, Peabody, MA 01960, USA
6Division of Gastroenterology, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
7Department of Veterinary Public Health, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
8Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan
9Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA

Tài liệu tham khảo

Abbas, 1996, Functional diversity of helper T lymphocytes, Nature, 383, 787, 10.1038/383787a0 Atarashi, 2008, ATP drives lamina propria T(H)17 cell differentiation, Nature, 455, 808, 10.1038/nature07240 Aujla, 2007, Th17 cells and mucosal host defense, Semin. Immunol., 19, 377, 10.1016/j.smim.2007.10.009 Backhed, 2005, Host-bacterial mutualism in the human intestine, Science, 307, 1915, 10.1126/science.1104816 Barman, 2008, Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract, Infect. Immun., 76, 907, 10.1128/IAI.01432-07 Bettelli, 2007, T(H)-17 cells in the circle of immunity and autoimmunity, Nat. Immunol., 8, 345, 10.1038/ni0407-345 Brandl, 2008, Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits, Nature, 455, 804, 10.1038/nature07250 Brodie, 2006, Application of a high-density oligonucleotide microarray approach to study bacterial population dynamics during uranium reduction and reoxidation, Appl. Environ. Microbiol., 72, 6288, 10.1128/AEM.00246-06 Cash, 2006, Symbiotic bacteria direct expression of an intestinal bactericidal lectin, Science, 313, 1126, 10.1126/science.1127119 Curtis, 2009, Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens, Immunology, 126, 177, 10.1111/j.1365-2567.2008.03017.x Davis, 1974, Habitat, succession, attachment, and morphology of segmented, filamentous microbes indigenous to the murine gastrointestinal tract, Infect. Immun., 10, 948, 10.1128/iai.10.4.948-956.1974 Dennis, 2003, DAVID: Database for Annotation, Visualization, and Integrated Discovery, Genome Biol., 4, 3, 10.1186/gb-2003-4-5-p3 DeSantis, 2007, High-density universal 16S rRNA microarray analysis reveals broader diversity than typical clone library when sampling the environment, Microb. Ecol., 53, 371, 10.1007/s00248-006-9134-9 Dewhirst, 1999, Phylogeny of the defined murine microbiota: altered Schaedler flora, Appl. Environ. Microbiol., 65, 3287, 10.1128/AEM.65.8.3287-3292.1999 Duerr, 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene, Science, 314, 1461, 10.1126/science.1135245 Elson, 2005, Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota, Immunol. Rev., 206, 260, 10.1111/j.0105-2896.2005.00291.x Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat. Immunol., 4, 330, 10.1038/ni904 Furlaneto, 2000, A novel function of serum amyloid A: a potent stimulus for the release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 by human blood neutrophil, Biochem. Biophys. Res. Commun., 268, 405, 10.1006/bbrc.2000.2143 Garland, 1982, Segmented filamentous bacteria in the rodent small intestine: their colonization of growing animals and possible role in host resistance to Salmonella, Microb. Ecol., 8, 181, 10.1007/BF02010451 Gavin, 2003, Control of immune homeostasis by naturally arising regulatory CD4+ T cells, Curr. Opin. Immunol., 15, 690, 10.1016/j.coi.2003.09.011 Glimcher, 2000, Lineage commitment in the immune system: the T helper lymphocyte grows up, Genes Dev., 14, 1693, 10.1101/gad.14.14.1693 Hall, 2008, Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses, Immunity, 29, 637, 10.1016/j.immuni.2008.08.009 He, 2006, Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23, J. Immunol., 177, 4072, 10.4049/jimmunol.177.6.4072 Heczko, 2000, Segmented filamentous bacteria prevent colonization of enteropathogenic Escherichia coli O103 in rabbits, J. Infect. Dis., 181, 1027, 10.1086/315348 Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490 Huang da, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc., 4, 44, 10.1038/nprot.2008.211 Hue, 2006, Interleukin-23 drives innate and T cell-mediated intestinal inflammation, J. Exp. Med., 203, 2473, 10.1084/jem.20061099 Itoh, 1985, Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice, Lab. Anim., 19, 111, 10.1258/002367785780942589 Ivanov, 2008, Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine, Cell Host Microbe, 4, 337, 10.1016/j.chom.2008.09.009 Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035 Khattri, 2003, An essential role for Scurfin in CD4+CD25+ T regulatory cells, Nat. Immunol., 4, 337, 10.1038/ni909 Kim, 2005, Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria, Gastroenterology, 128, 891, 10.1053/j.gastro.2005.02.009 Klaasen, 1993, Intestinal, segmented, filamentous bacteria in a wide range of vertebrate species, Lab. Anim., 27, 141, 10.1258/002367793780810441 Klaasen, 1993, Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice, Infect. Immun., 61, 303, 10.1128/iai.61.1.303-306.1993 Kolls, 2008, Cytokine-mediated regulation of antimicrobial proteins, Nat. Rev. Immunol., 8, 829, 10.1038/nri2433 Koopman, 1987, The attachment of filamentous segmented micro-organisms to the distal ileum wall of the mouse: a scanning and transmission electron microscopy study, Lab. Anim., 21, 48, 10.1258/002367787780740743 Krueger, 2007, A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis, N. Engl. J. Med., 356, 580, 10.1056/NEJMoa062382 Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J. Exp. Med., 201, 233, 10.1084/jem.20041257 Leppkes, 2009, RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F, Gastroenterology, 136, 257, 10.1053/j.gastro.2008.10.018 Ley, 2008, Evolution of mammals and their gut microbes, Science, 320, 1647, 10.1126/science.1155725 Macpherson, 2004, Interactions between commensal intestinal bacteria and the immune system, Nat. Rev. Immunol., 4, 478, 10.1038/nri1373 Mangan, 2006, Transforming growth factor-beta induces development of the T(H)17 lineage, Nature, 441, 231, 10.1038/nature04754 Mazmanian, 2005, An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system, Cell, 122, 107, 10.1016/j.cell.2005.05.007 Mazmanian, 2008, A microbial symbiosis factor prevents intestinal inflammatory disease, Nature, 453, 620, 10.1038/nature07008 Miyamoto, 2000, Bacteroides acidifaciens sp. nov., isolated from the caecum of mice, Int. J. Syst. Evol. Microbiol., 50, 145, 10.1099/00207713-50-1-145 Monach, 2008, The K/BxN arthritis model, Curr. Protoc. Immunol., Chapter 15, Unit 15 22 Murphy, 2003, Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation, J. Exp. Med., 198, 1951, 10.1084/jem.20030896 O'Dell, 2006, Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone, Arthritis Rheum., 54, 621, 10.1002/art.21620 Rakoff-Nahoum, 2006, Role of the innate immune system and host-commensal mutualism, Curr. Top. Microbiol. Immunol., 308, 1 Sartor, 2008, Microbial influences in inflammatory bowel diseases, Gastroenterology, 134, 577, 10.1053/j.gastro.2007.11.059 Seder, 1994, Acquisition of lymphokine-producing phenotype by CD4+ T cells, Annu. Rev. Immunol., 12, 635, 10.1146/annurev.iy.12.040194.003223 Severijnen, 1989, Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats, J. Rheumatol., 16, 1061 Simelyte, 2003, Role of peptidoglycan subtypes in the pathogenesis of bacterial cell wall arthritis, Ann. Rheum. Dis., 62, 976, 10.1136/ard.62.10.976 Snel, 1995, Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of “Candidatus Arthromitus”, Int. J. Syst. Bacteriol., 45, 780, 10.1099/00207713-45-4-780 Suzuki, 2004, Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut, Proc. Natl. Acad. Sci. USA, 101, 1981, 10.1073/pnas.0307317101 Talham, 1999, Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system, Infect. Immun., 67, 1992, 10.1128/IAI.67.4.1992-2000.1999 Torchinsky, 2009, Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation, Nature, 458, 78, 10.1038/nature07781 Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414 Uhlar, 1999, Serum amyloid A, the major vertebrate acute-phase reactant, Eur. J. Biochem., 265, 501, 10.1046/j.1432-1327.1999.00657.x Umesaki, 1995, Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse, Microbiol. Immunol., 39, 555, 10.1111/j.1348-0421.1995.tb02242.x Umesaki, 1999, Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system, Infect. Immun., 67, 3504, 10.1128/IAI.67.7.3504-3511.1999 Veldhoen, 2006, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, 24, 179, 10.1016/j.immuni.2006.01.001 Yen, 2006, IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6, J. Clin. Invest., 116, 1310, 10.1172/JCI21404 Zheng, 2008, Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, Nat. Med., 14, 282, 10.1038/nm1720 Zhou, 2008, TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function, Nature, 453, 236, 10.1038/nature06878