Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: In vitro plasma inactivation and pharmacological activity of its main metabolites

Barnes, 2004, The role of anticholinergics in chronic obstructive pulmonary disease, Am. J. Med., 117, 24S Ferrer, 2008, Pharmacokinetics and safety of aclidinium bromide, a novel long-acting, inhaled anticholinergic, in healthy subjects, Am. J. Respir. Crit. Care Med., 177, A655 Gavaldà, 2009, Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile, J. Pharmacol. Exp. Ther., 331, 740, 10.1124/jpet.109.151639 Gras, 2008, The preclinical safety profile of aclidinium bromide, a novel long-acting anticholinergic drug, Am. J. Respir. Crit. Care Med., 177, A654 Gras, 2008, The preclinical urinary and renal safety profile of aclidinium bromide, a novel long-acting anticholinergic drug, Eur. Resp. J., 32, P3640 Gross, 1984, Role of the parasympathetic system in airway obstruction due to emphysema, N. Engl. J. Med., 311, 421, 10.1056/NEJM198408163110701 Gross, 1984, Anticholinergic, antimuscarinic bronchodilators, Am. Rev. Respir. Dis., 129, 856, 10.1164/arrd.1984.129.5.856 Gross, 1988, Ipratropium bromide, N. Engl. J. Med., 319, 486, 10.1056/NEJM198808253190806 Gross, 2006, Anticholinergic agents in asthma and COPD, Eur. J. Pharmacol., 533, 36, 10.1016/j.ejphar.2005.12.072 Hanania, 2007, Pharmacologic interventions in chronic obstructive pulmonary disease: bronchodilators, Proc. Am. Thorac. Soc., 4, 526, 10.1513/pats.200701-016FM Jansat, 2009, Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects, Int. J. Clin. Pharmacol. Ther., 47, 460, 10.5414/CPP47460 Kesten, 2006, Pooled clinical trial analysis of tiotropium safety, Chest, 130, 1695, 10.1378/chest.130.6.1695 Lee, 2008, Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease, Ann. Intern. Med., 149, 380, 10.7326/0003-4819-149-6-200809160-00004 Lieberman, 2004, Managing anticholinergic side effects, Prim. Care Companion J. Clin. Psychiatry, 6, 20 Lopez, 2006, Chronic obstructive pulmonary disease: current burden and future projections, Eur. Respir. J., 27, 397, 10.1183/09031936.06.00025805 Montero, 2008, Effect of aclidinium bromide, a novel long-acting anticholinergic, on salivation, colonic motility and faecal output in different animal models, Eur. Resp. J., 32, P3637 Prat, 2009, J. Med. Chem., 52, 5076, 10.1021/jm900132z Rabe, 2007, Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary, Am. J. Respir. Crit. Care Med., 176, 532, 10.1164/rccm.200703-456SO Singh, 2008, Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease. A systematic review and meta-analysis, JAMA, 300, 12, 10.1001/jama.300.12.1439