Successful Reprogramming of Epiblast Stem Cells by Blocking Nuclear Localization of β-Catenin

Bao, 2009, Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells, Nature, 461, 1292, 10.1038/nature08534 Brons, 2007, Derivation of pluripotent epiblast stem cells from mammalian embryos, Nature, 448, 191, 10.1038/nature05950 Chen, 2009, Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer, Nat. Chem. Biol., 5, 100, 10.1038/nchembio.137 Chen, 2010, E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation, Stem Cells, 28, 1315, 10.1002/stem.456 Conacci-Sorrell, 2003, Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK, J. Cell Biol., 163, 847, 10.1083/jcb.200308162 del Valle, 2013, E-cadherin is required for the proper activation of the Lifr/Gp130 signaling pathway in mouse embryonic stem cells, Development, 140, 1684, 10.1242/dev.088690 Evans, 1981, Establishment in culture of pluripotential cells from mouse embryos, Nature, 292, 154, 10.1038/292154a0 Gafni, 2013, Derivation of novel human ground state naive pluripotent stem cells, Nature, 504, 282, 10.1038/nature12745 Gillich, 2012, Epiblast stem cell-based system reveals reprogramming synergy of germline factors, Cell Stem Cell, 10, 425, 10.1016/j.stem.2012.01.020 Hanna, 2010, Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs, Proc. Natl. Acad. Sci. USA, 107, 9222, 10.1073/pnas.1004584107 Huang, 2009, Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling, Nature, 461, 614, 10.1038/nature08356 Kim, 2013, Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal, Nat. Commun., 4, 2403, 10.1038/ncomms3403 Kobayashi, 2010, Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells, Cell, 142, 787, 10.1016/j.cell.2010.07.039 Li, 2009, Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors, Cell Stem Cell, 4, 16, 10.1016/j.stem.2008.11.014 Martin, 1981, Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells, Proc. Natl. Acad. Sci. USA, 78, 7634, 10.1073/pnas.78.12.7634 Nichols, 2009, Naive and primed pluripotent states, Cell Stem Cell, 4, 487, 10.1016/j.stem.2009.05.015 Nichols, 2006, Derivation and propagation of embryonic stem cells in serum- and feeder-free culture, Methods Mol. Biol., 329, 91 Niwa, 2002, Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells, Mol. Cell. Biol., 22, 1526, 10.1128/MCB.22.5.1526-1536.2002 Ogawa, 2004, A novel mechanism for regulating clonal propagation of mouse ES cells, Genes Cells, 9, 471, 10.1111/j.1356-9597.2004.00736.x Ohtsuka, 2012, E-cadherin promotes incorporation of mouse epiblast stem cells into normal development, PLoS ONE, 7, e45220, 10.1371/journal.pone.0045220 Sasaki, 2000, Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin, Cancer Res., 60, 7057 Silva, 2009, Nanog is the gateway to the pluripotent ground state, Cell, 138, 722, 10.1016/j.cell.2009.07.039 Smith, 1988, Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides, Nature, 336, 688, 10.1038/336688a0 Staal, 2002, Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin, EMBO Rep., 3, 63, 10.1093/embo-reports/kvf002 Stockinger, 2001, E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity, J. Cell Biol., 154, 1185, 10.1083/jcb.200104036 Tesar, 2007, New cell lines from mouse epiblast share defining features with human embryonic stem cells, Nature, 448, 196, 10.1038/nature05972 Toyooka, 2008, Identification and characterization of subpopulations in undifferentiated ES cell culture, Development, 135, 909, 10.1242/dev.017400 Veeman, 2003, Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements, Curr. Biol., 13, 680, 10.1016/S0960-9822(03)00240-9 Ware, 2014, Derivation of naive human embryonic stem cells, Proc. Natl. Acad. Sci. USA, 111, 4484, 10.1073/pnas.1319738111 Wray, 2010, The ground state of pluripotency, Biochem. Soc. Trans., 38, 1027, 10.1042/BST0381027 Wray, 2011, Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation, Nat. Cell Biol., 13, 838, 10.1038/ncb2267 Yamaguchi, 2012, Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming, PLoS ONE, 7, e41007, 10.1371/journal.pone.0041007 Ying, 2003, BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3, Cell, 115, 281, 10.1016/S0092-8674(03)00847-X Ying, 2008, The ground state of embryonic stem cell self-renewal, Nature, 453, 519, 10.1038/nature06968