A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

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Galanter, 2008, ORMDL3 gene is associated with asthma in three ethnically diverse populations, Am J Respir Crit Care Med, 177, 1194, 10.1164/rccm.200711-1644OC

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Bisgaard, 2009, Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood, Am J Respir Crit Care Med, 179, 179, 10.1164/rccm.200809-1436OC

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Scholtens, 2014, Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure, J Allergy Clin Immunol, 133, 885, 10.1016/j.jaci.2013.08.049

Stokholm, 2017, Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant, J Allergy Clin Immunol

Granell, 2013, Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes, J Allergy Clin Immunol, 131, 685, 10.1016/j.jaci.2012.09.021

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Granada, 2012, A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study, J Allergy Clin Immunol, 129, 840, 10.1016/j.jaci.2011.09.029

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Tomita, 2013, Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population, Allergy, 68, 92, 10.1111/all.12066

Ramasamy, 2011, A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order, J Allergy Clin Immunol, 128, 996, 10.1016/j.jaci.2011.08.030

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Yao, 2014, Genome-wide association study of lung function phenotypes in a founder population, J Allergy Clin Immunol, 133, 248, 10.1016/j.jaci.2013.06.018

van der Valk, 2014, Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants, J Allergy Clin Immunol, 134, 46, 10.1016/j.jaci.2013.08.053

Bouzigon, 2015, A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults, Clin Exp Allergy, 45, 797, 10.1111/cea.12461

Gudbjartsson, 2009, Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction, Nat Genet, 41, 342, 10.1038/ng.323

Barrett, 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nat Genet, 40, 955, 10.1038/ng.175

Anderson, 2011, Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47, Nat Genet, 43, 246, 10.1038/ng.764

Huang, 2015, Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans, Gastroenterology, 149, 1575, 10.1053/j.gastro.2015.07.065

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Stahl, 2010, Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci, Nat Genet, 42, 508, 10.1038/ng.582

Mells, 2011, Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis, Nat Genet, 43, 329, 10.1038/ng.789

Hirschfield, 2009, Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants, N Engl J Med, 360, 2544, 10.1056/NEJMoa0810440

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