Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

Kidney International - Tập 83 Số 4 - Trang 568-581 - 2013
Ming Zhan1, Craig R. Brooks2, Fuyou Liu1, Lin Sun1, Zheng Dong2,1
1Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China
2Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, Georgia, USA

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Westermann, 2010, Mitochondrial fusion and fission in cell life and death, Nat Rev Mol Cell Biol, 11, 872, 10.1038/nrm3013

Liesa, 2009, Mitochondrial dynamics in mammalian health and disease, Physiol Rev, 89, 799, 10.1152/physrev.00030.2008

Detmer, 2007, Functions and dysfunctions of mitochondrial dynamics, Nat Rev Mol Cell Biol, 8, 870, 10.1038/nrm2275

Suen, 2008, Mitochondrial dynamics and apoptosis, Genes Dev, 22, 1577, 10.1101/gad.1658508

Twig, 2008, Fission and selective fusion govern mitochondrial segregation and elimination by autophagy, Embo J, 27, 433, 10.1038/sj.emboj.7601963

Seo, 2010, New insights into the role of mitochondria in aging: mitochondrial dynamics and more, J Cell Sci, 123, 2533, 10.1242/jcs.070490

McBride, 2006, Mitochondria: more than just a powerhouse, Curr Biol, 16, R551, 10.1016/j.cub.2006.06.054

Okamoto, 2005, Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes, Annu Rev Genet, 39, 503, 10.1146/annurev.genet.38.072902.093019

Osteryoung, 2003, The division of endosymbiotic organelles, Science, 302, 1698, 10.1126/science.1082192

Hales, 1997, Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase, Cell, 90, 121, 10.1016/S0092-8674(00)80319-0

Chen, 2004, Mitochondrial dynamics in mammals, Curr Top Dev Biol, 59, 119, 10.1016/S0070-2153(04)59005-1

Meeusen, 2006, Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1, Cell, 127, 383, 10.1016/j.cell.2006.09.021

Chen, 2009, Mitochondrial dynamics—fusion, fission, movement, and mitophagy—in neurodegenerative diseases, Hum Mol Genet, 18, R169, 10.1093/hmg/ddp326

Waterham, 2007, A lethal defect of mitochondrial and peroxisomal fission, N Engl J Med, 356, 1736, 10.1056/NEJMoa064436

Pitts, 2004, Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains, J Biol Chem, 279, 50286, 10.1074/jbc.M405531200

Ingerman, 2005, Dnm1 forms spirals that are structurally tailored to fit mitochondria, J Cell Biol, 170, 1021, 10.1083/jcb.200506078

Wasiak, 2007, Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death, J Cell Biol, 177, 439, 10.1083/jcb.200610042

Smirnova, 2001, Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells, Mol Biol Cell, 12, 2245, 10.1091/mbc.12.8.2245

Yoon, 2003, The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1, Mol Cell Biol, 23, 5409, 10.1128/MCB.23.15.5409-5420.2003

Lee, 2004, Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis, Mol Biol Cell, 15, 5001, 10.1091/mbc.e04-04-0294

Song, 2011, Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity, Nat Med, 17, 377, 10.1038/nm.2313

Ishihara, 2009, Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice, Nat Cell Biol, 11, 958, 10.1038/ncb1907

Dohm, 2004, Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold, Proteins, 54, 153, 10.1002/prot.10524

Suzuki, 2005, Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission, J Biol Chem, 280, 21444, 10.1074/jbc.M414092200

James, 2003, hFis1, a novel component of the mammalian mitochondrial fission machinery, J Biol Chem, 278, 36373, 10.1074/jbc.M303758200

Stojanovski, 2004, Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology, J Cell Sci, 117, 1201, 10.1242/jcs.01058

Cuddeback, 2001, Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax, J Biol Chem, 276, 20559, 10.1074/jbc.M101527200

Rostovtseva, 2009, Bax activates endophilin B1 oligomerization and lipid membrane vesiculation, J Biol Chem, 284, 34390, 10.1074/jbc.M109.021873

Peter, 2004, BAR domains as sensors of membrane curvature: the amphiphysin BAR structure, Science, 303, 495, 10.1126/science.1092586

Karbowski, 2004, Endophilin B1 is required for the maintenance of mitochondrial morphology, J Cell Biol, 166, 1027, 10.1083/jcb.200407046

Tondera, 2005, The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells, J Cell Sci, 118, 3049, 10.1242/jcs.02415

Cipolat, 2004, OPA1 requires mitofusin 1 to promote mitochondrial fusion, Proc Natl Acad Sci USA, 101, 15927, 10.1073/pnas.0407043101

Santel, 2001, Control of mitochondrial morphology by a human mitofusin, J Cell Sci, 114, 867, 10.1242/jcs.114.5.867

Koshiba, 2004, Structural basis of mitochondrial tethering by mitofusin complexes, Science, 305, 858, 10.1126/science.1099793

Meeusen, 2004, Mitochondrial fusion intermediates revealed in vitro, Science, 305, 1747, 10.1126/science.1100612

Ishihara, 2004, Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity, J Cell Sci, 117, 6535, 10.1242/jcs.01565

Chan, 2006, Mitochondrial fusion and fission in mammals, Annu Rev Cell Dev Biol, 22, 79, 10.1146/annurev.cellbio.22.010305.104638

Chen, 2005, Disruption of fusion results in mitochondrial heterogeneity and dysfunction, J Biol Chem, 280, 26185, 10.1074/jbc.M503062200

Chen, 2003, Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development, J Cell Biol, 160, 189, 10.1083/jcb.200211046

Zuchner, 2004, Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, Nat Genet, 36, 449, 10.1038/ng1341

Chen, 2007, Mitochondrial fusion protects against neurodegeneration in the cerebellum, Cell, 130, 548, 10.1016/j.cell.2007.06.026

Chen, 2010, Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations, Cell, 141, 280, 10.1016/j.cell.2010.02.026

Baumann, 2010, Organelle dynamics: Fusing for stability, Nat Rev Mol Cell Biol, 11, 391, 10.1038/nrm2910

Chen, 2004, Dysregulation of HSG triggers vascular proliferative disorders, Nat Cell Biol, 6, 872, 10.1038/ncb1161

de Brito, 2008, Mitofusin 2 tethers endoplasmic reticulum to mitochondria, Nature, 456, 605, 10.1038/nature07534

Hailey, 2010, Mitochondria supply membranes for autophagosome biogenesis during starvation, Cell, 141, 656, 10.1016/j.cell.2010.04.009

Yoon, 2011, Mitochondrial dynamics in diabetes, Antioxid Redox Signal, 14, 439, 10.1089/ars.2010.3286

Delettre, 2000, Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nat Genet, 26, 207, 10.1038/79936

Alexander, 2000, OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28, Nat Genet, 26, 211, 10.1038/79944

Delettre, 2001, Mutation spectrum and splicing variants in the OPA1 gene, Hum Genet, 109, 584, 10.1007/s00439-001-0633-y

Ishihara, 2006, Regulation of mitochondrial morphology through proteolytic cleavage of OPA1, Embo J, 25, 2966, 10.1038/sj.emboj.7601184

Frezza, 2006, OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion, Cell, 126, 177, 10.1016/j.cell.2006.06.025

Cipolat, 2006, Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling, Cell, 126, 163, 10.1016/j.cell.2006.06.021

Ehses, 2009, Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1, J Cell Biol, 187, 1023, 10.1083/jcb.200906084

Head, 2009, Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells, J Cell Biol, 187, 959, 10.1083/jcb.200906083

McBride, 2010, Mitochondrial function: OMA1 and OPA1, the grandmasters of mitochondrial health, Curr Biol, 20, R274, 10.1016/j.cub.2010.02.011

Quiros, 2012, Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice, EMBO J, 31, 2117, 10.1038/emboj.2012.70

Zhang, 2011, The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells, Mol Biol Cell, 22, 2235, 10.1091/mbc.e10-12-0933

Amati-Bonneau, 2008, OPA1 mutations induce mitochondrial DNA instability and optic atrophy ‘plus’ phenotypes, Brain, 131, 338, 10.1093/brain/awm298

Yu-Wai-Man, 2010, OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules, Hum Mol Genet, 19, 3043, 10.1093/hmg/ddq209

Youle, 2008, The BCL-2 protein family: opposing activities that mediate cell death, Nat Rev Mol Cell Biol, 9, 47, 10.1038/nrm2308

Martinou, 2011, Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics, Dev Cell, 21, 92, 10.1016/j.devcel.2011.06.017

Karbowski, 2002, Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis, J Cell Biol, 159, 931, 10.1083/jcb.200209124

Karbowski, 2006, Role of Bax and Bak in mitochondrial morphogenesis, Nature, 443, 658, 10.1038/nature05111

Brooks, 2007, Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins, Proc Natl Acad Sci USA, 104, 11649, 10.1073/pnas.0703976104

Brooks, 2009, Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models, J Clin Invest, 119, 1275, 10.1172/JCI37829

Chang, 2007, Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology, J Biol Chem, 282, 21583, 10.1074/jbc.C700083200

Taguchi, 2007, Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission, J Biol Chem, 282, 11521, 10.1074/jbc.M607279200

Cribbs, 2007, Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death, EMBO Rep, 8, 939, 10.1038/sj.embor.7401062

Han, 2008, CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology, J Cell Biol, 182, 573, 10.1083/jcb.200802164

Cereghetti, 2008, Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria, Proc Natl Acad Sci USA, 105, 15803, 10.1073/pnas.0808249105

Cho, 2010, Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis, Am J Physiol Renal Physiol, 299, F199, 10.1152/ajprenal.00716.2009

Karbowski, 2007, The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division, J Cell Biol, 178, 71, 10.1083/jcb.200611064

Zunino, 2007, The SUMO protease SENP5 is required to maintain mitochondrial morphology and function, J Cell Sci, 120, 1178, 10.1242/jcs.03418

Cho, 2009, S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury, Science, 324, 102, 10.1126/science.1171091

Wang, 2012, Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells, Cell Metab, 15, 186, 10.1016/j.cmet.2012.01.009

Nowak, 2011, Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules, Am J Physiol Renal Physiol, 301, F197, 10.1152/ajprenal.00364.2010

Qi, 2011, Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo, Mol Biol Cell, 22, 256, 10.1091/mbc.e10-06-0551

Harder, 2004, Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission, Curr Biol, 14, 340, 10.1016/j.cub.2004.02.004

Dong, 2006, Calcium in cell injury and death, Annu Rev Pathol, 1, 405, 10.1146/annurev.pathol.1.110304.100218

Wang, 1999, Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD, Science, 284, 339, 10.1126/science.284.5412.339

Wang, 2011, miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1, Nat Med, 17, 71, 10.1038/nm.2282

Orrenius, 2007, Mitochondrial oxidative stress: implications for cell death, Annu Rev Pharmacol Toxicol, 47, 143, 10.1146/annurev.pharmtox.47.120505.105122

Makino, 2010, Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes, Diabetologia, 53, 1783, 10.1007/s00125-010-1770-4

Grohm, 2010, Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death, Brain Behav Immun, 24, 831, 10.1016/j.bbi.2009.11.015

Wu, 2011, Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins, FEBS J, 278, 941, 10.1111/j.1742-4658.2011.08010.x

Yu, 2006, Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology, Proc Natl Acad Sci USA, 103, 2653, 10.1073/pnas.0511154103

Yu, 2008, Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species, Cardiovasc Res, 79, 341, 10.1093/cvr/cvn104

Shenouda, 2011, Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus, Circulation, 124, 444, 10.1161/CIRCULATIONAHA.110.014506

Baines, 2005, Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death, Nature, 434, 658, 10.1038/nature03434

Rasola, 2010, Signal transduction to the permeability transition pore, FEBS Lett, 584, 1989, 10.1016/j.febslet.2010.02.022

Halestrap, 2009, The role of the mitochondrial permeability transition pore in heart disease, Biochim Biophys Acta, 1787, 1402, 10.1016/j.bbabio.2008.12.017

Nakagawa, 2005, Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death, Nature, 434, 652, 10.1038/nature03317

Schinzel, 2005, Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia, Proc Natl Acad Sci USA, 102, 12005, 10.1073/pnas.0505294102

Devalaraja-Narashimha, 2009, Cyclophilin D gene ablation protects mice from ischemic renal injury, Am J Physiol Renal Physiol, 297, F749, 10.1152/ajprenal.00239.2009

Park, 2011, Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury, Am J Physiol Renal Physiol, 301, F134, 10.1152/ajprenal.00033.2011

Feldkamp, 2009, Regulation of the mitochondrial permeability transition in kidney proximal tubules and its alteration during hypoxia-reoxygenation, Am J Physiol Renal Physiol, 297, F1632, 10.1152/ajprenal.00422.2009

Hunter, 1979, The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms, Arch Biochem Biophys, 195, 453, 10.1016/0003-9861(79)90371-0

Brooks, 2007, Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: a key in Bak?, Cell Cycle, 6, 3043, 10.4161/cc.6.24.5115

Wei, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108

Brooks, 2011, Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis, Am J Physiol Cell Physiol, 300, C447, 10.1152/ajpcell.00402.2010

Gall, 2012, Role of mitofusin 2 in the renal stress response, PloS one, 7, e31074, 10.1371/journal.pone.0031074

Montessuit, 2010, Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization, Cell, 142, 889, 10.1016/j.cell.2010.08.017

Scorrano, 2002, A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis, Dev Cell, 2, 55, 10.1016/S1534-5807(01)00116-2

Germain, 2005, Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis, EMBO J, 24, 1546, 10.1038/sj.emboj.7600592

Ulivieri, 2010, Cell death: insights into the ultrastructure of mitochondria, Tissue Cell, 42, 339, 10.1016/j.tice.2010.10.004

Olichon, 2003, Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis, J Biol Chem, 278, 7743, 10.1074/jbc.C200677200

Estaquier, 2007, Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis, Cell Death Differ, 14, 1086, 10.1038/sj.cdd.4402107

Gottlieb, 2006, OPA1 and PARL keep a lid on apoptosis, Cell, 126, 27, 10.1016/j.cell.2006.06.030

Scorrano, 2009, Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis, Int J Biochem Cell Biol, 41, 1875, 10.1016/j.biocel.2009.04.016

Palorini, 2012, Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration

Bach, 2003, Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity, J Biol Chem, 278, 17190, 10.1074/jbc.M212754200

Chen, 2011, Mitochondrial fusion is essential for organelle function and cardiac homeostasis, Circ Res, 109, 1327, 10.1161/CIRCRESAHA.111.258723

Benard, 2007, Mitochondrial bioenergetics and structural network organization, J Cell Sci, 120, 838, 10.1242/jcs.03381

Liu, 2011, Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission, Proc Natl Acad Sci USA, 108, 12920, 10.1073/pnas.1107332108

Kageyama, 2012, Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage, J Cell Biol, 197, 535, 10.1083/jcb.201110034

Zhang, 2012, Mitochondrial division prevents neurodegeneration, 8

Bonventre, 2011, Cellular pathophysiology of ischemic acute kidney injury, J Clin Invest, 121, 4210, 10.1172/JCI45161

Sharfuddin, 2011, Pathophysiology of ischemic acute kidney injury, Nat Rev Nephrol, 7, 189, 10.1038/nrneph.2011.16

Weinberg, 2011, Mitochondrial biogenesis in kidney disease, J Am Soc Nephrol, 22, 431, 10.1681/ASN.2010060643

Kanwar, 2011, A glimpse of various pathogenetic mechanisms of diabetic nephropathy, Annu Rev Pathol, 6, 395, 10.1146/annurev.pathol.4.110807.092150

Sun, 2008, Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction, J Am Soc Nephrol, 19, 2293, 10.1681/ASN.2008030336

Lo, 2009, Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease, Kidney Int, 76, 893, 10.1038/ki.2009.289

Lafrance, 2010, Acute kidney injury associates with increased long-term mortality, J Am Soc Nephrol, 21, 345, 10.1681/ASN.2009060636

Venkatachalam, 2010, Acute kidney injury: a springboard for progression in chronic kidney disease, Am J Physiol Renal Physiol, 298, F1078, 10.1152/ajprenal.00017.2010

Sanoff, 2011, Impact of acute kidney injury on chronic kidney disease and its progression, Contrib Nephrol, 171, 213, 10.1159/000327332

Devarajan, 2006, Update on mechanisms of ischemic acute kidney injury, J Am Soc Nephrol, 17, 1503, 10.1681/ASN.2006010017

Havasi, 2011, Apoptosis and acute kidney injury, Kidney Int, 80, 29, 10.1038/ki.2011.120

Pabla, 2008, Cisplatin nephrotoxicity: mechanisms and renoprotective strategies, Kidney Int, 73, 994, 10.1038/sj.ki.5002786

Weinberg, 1982, Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. I. Direct effects of in vitro mercuric chloride on renal mitochondrial function, J Biol Chem, 257, 60, 10.1016/S0021-9258(19)68325-0

Weinberg, 1982, Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury. II. Functional alterations of renal cortical mitochondria isolated after mercuric chloride treatment, J Biol Chem, 257, 68, 10.1016/S0021-9258(19)68326-2

Castaneda, 2003, Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injury, Transplantation, 76, 50, 10.1097/01.TP.0000069835.95442.9F

Ong, 2010, Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury, Circulation, 121, 2012, 10.1161/CIRCULATIONAHA.109.906610

Kumar, 2004, Evidence of apoptosis in human diabetic kidney, Mol Cell Biochem, 259, 67, 10.1023/B:MCBI.0000021346.03260.7e

Hall, 2007, The not so ‘mighty chondrion’: emergence of renal diseases due to mitochondrial dysfunction, Nephron Physiol, 105, p1, 10.1159/000096860

Zorov, 2010, Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria, Kidney Int, 77, 841, 10.1038/ki.2010.20

Casalena, 2012, Transforming growth factor-beta, bioenergetics, and mitochondria in renal disease, Semin Nephrol, 32, 295, 10.1016/j.semnephrol.2012.04.009

Feldkamp, 2004, Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules, Am J Physiol Renal Physiol, 286, F749, 10.1152/ajprenal.00276.2003

Funk, 2012, Persistent disruption of mitochondrial homeostasis after acute kidney injury, Am J Physiol Renal Physiol, 302, F853, 10.1152/ajprenal.00035.2011

Coughlan, 2009, RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes, J Am Soc Nephrol, 20, 742, 10.1681/ASN.2008050514

Munusamy, 2009, Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells, Free Radic Biol Med, 46, 1149, 10.1016/j.freeradbiomed.2009.01.022

Park, 2011, A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina, Invest Ophthalmol Vis Sci, 52, 2837, 10.1167/iovs.09-5010

Jheng, 2012, Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle, Mol Cell Biol, 32, 309, 10.1128/MCB.05603-11

Ferrari, 2011, Role of Drp1, a key mitochondrial fission protein, in neuropathic pain, J Neurosci, 31, 11404, 10.1523/JNEUROSCI.2223-11.2011

Tang, 2012, Early protective effect of mitofusion 2 overexpression in STZ-induced diabetic rat kidney, Endocrine, 41, 236, 10.1007/s12020-011-9555-1

Oettinghaus, 2012, Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration, Acta Neuropathol, 123, 189, 10.1007/s00401-011-0930-z

Lackner, 2010, Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine, Chem Biol, 17, 578, 10.1016/j.chembiol.2010.05.016