A different gut microbiome linked to inflammation found in cirrhotic patients with and without hepatocellular carcinoma

Annals of Hepatology - Tập 18 - Trang 480-487 - 2019
Federico Piñero1,2, Martín Vazquez3, Patricia Baré4, Cristian Rohr3, Manuel Mendizabal1,2, Mariela Sciara3, Cristina Alonso1,2, Fabián Fay3, Marcelo Silva1,2
1Hospital Universitario Austral, Liver Transplant and Hepatology Unit, Austral University School of Medicine, Argentina
2Latin American Liver Research, Education and Awareness Network (LALREAN), Argentina
3Heritas, Rosario, Santa Fe, Argentina
4IMEX, CONICET, National Academy of Medicine, Buenos Aires, Argentina

Tài liệu tham khảo

Chen, 2011, Characterization of fecal microbial communities in patients with liver cirrhosis, Hepatology, 54, 562, 10.1002/hep.24423 Bajaj, 2014, Altered profile of human gut microbiome is associated with cirrhosis and its complications, J Hepatol, 60, 940, 10.1016/j.jhep.2013.12.019 Qin, 2014, Alterations of the human gut microbiome in liver cirrhosis, Nature, 513, 59, 10.1038/nature13568 Grąt, 2014, Gut microbiota in cirrhotic liver transplant candidates, Hepatogastroenterology, 61, 1661 Chen, 2015, Gut dysbiosis in acute-on-chronic liver failure and its predictive value for mortality, J Gastroenterol Hepatol, 30, 1429, 10.1111/jgh.12932 D’Amico, 2014, The clinical course of cirrhosis. Population based studies and the need of personalized medicine, J Hepatol, 60, 241, 10.1016/j.jhep.2013.10.023 Sherman, 2010, Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis, Semin Liver Dis, 30, 3, 10.1055/s-0030-1247128 Ripoll, 2009, Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis, J Hepatol, 50, 923, 10.1016/j.jhep.2009.01.014 Dapito, 2012, Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4, Cancer Cell, 21, 504, 10.1016/j.ccr.2012.02.007 Zhang, 2012, Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats, J Hepatol, 57, 803, 10.1016/j.jhep.2012.06.011 Darnaud, 2013, Targeting gut flora to prevent progression of hepatocellular carcinoma, J Hepatol, 58, 385, 10.1016/j.jhep.2012.08.019 von Elm, 2007, STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies, Lancet, 370, 1453, 10.1016/S0140-6736(07)61602-X 2010, EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis, J Hepatol, 53, 397, 10.1016/j.jhep.2010.05.004 Trotti, 2003, CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment, Semin Radiat Oncol, 13, 176, 10.1016/S1053-4296(03)00031-6 European Association for the Study of the Liver, 2012, EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis, J Hepatol, 56, 908, 10.1016/j.jhep.2011.12.001 Carbonetto, 2016, Human microbiota of the argentine population – a pilot study, Front Microbiol, 7, 51, 10.3389/fmicb.2016.00051 Xia, 2013, A logistic normal multinomial regression model for microbiome compositional data analysis, Biometrics, 69, 1053, 10.1111/biom.12079 Oksanen, 2011, 17 Mandal, 2015, Analysis of composition of microbiomes: a novel method for studying microbial composition, Microb Ecol Health Dis, 26, 27663 Shaw, 2010, NOD-like receptor (NLR) signaling beyond the inflammasome, Eur J Immunol, 40, 624, 10.1002/eji.200940211 Bajaj, 2016, HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients, Aliment Pharmacol Ther, 44, 638, 10.1111/apt.13732 Flemer, 2017, Tumour-associated and non-tumour-associated microbiota in colorectal cancer, Gut, 66, 633, 10.1136/gutjnl-2015-309595 Morgan, 2012, Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment, Genome Biol, 13, R79, 10.1186/gb-2012-13-9-r79 Zackular, 2013, The gut microbiome modulates colon tumorigenesis, MBio, 4, 10.1128/mBio.00692-13 Simpson, 2015, Review article: dietary fibre–microbiota interactions, Aliment Pharmacol Ther, 42, 158, 10.1111/apt.13248 Bultman, 2014, Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?, Cell Host Microbe, 16, 143, 10.1016/j.chom.2014.07.011 Li, 2016, Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice, Proc Natl Acad Sci USA, 113, E1306, 10.1073/pnas.1518189113 Ponziani, 2018, Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease, Hepatology Grat, 2016, Profile of gut microbiota associated with the presence of hepatocellular cancer in patients with liver cirrhosis, Transplant Proc, 48, 1687, 10.1016/j.transproceed.2016.01.077