BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
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Mangelsdorf, 1995, The nuclear receptor superfamily: the second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X
Mangelsdorf, 1995, The RXR heterodimers and orphan receptors, Cell, 83, 841, 10.1016/0092-8674(95)90200-7
Glass, 1994, Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers, Endocr. Rev., 15, 391
Glass, 2000, The coregulator exchange in transcriptional functions of nuclear receptors, Genes Dev., 14, 121, 10.1101/gad.14.2.121
Rosenfeld, 2001, Coregulator codes of transcriptional regulation by nuclear receptors, J. Biol. Chem., 276, 36865, 10.1074/jbc.R100041200
Forman, 1997, The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism, Proc. Natl. Acad. Sci. USA., 94, 10588, 10.1073/pnas.94.20.10588
Lehmann, 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J. Biol. Chem., 272, 3137, 10.1074/jbc.272.6.3137
Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha, Nature, 383, 728, 10.1038/383728a0
Parks, 1999, Bile acids: natural ligands for an orphan nuclear receptor, Science, 284, 1365, 10.1126/science.284.5418.1365
Makishima, 1999, Identification of a nuclear receptor for bile acids, Science, 284, 1362, 10.1126/science.284.5418.1362
Wang, 1999, Endogenous bile acids are ligands for the nuclear receptor FXR/BAR, Mol. Cell., 3, 543, 10.1016/S1097-2765(00)80348-2
Staudinger, 2001, The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity, Proc. Natl. Acad. Sci. USA., 98, 3369, 10.1073/pnas.051551698
Xie, 2001, An essential role for nuclear receptors SXR/RXR in detoxification of cholestatic bile acids, Proc. Natl. Acad. Sci. USA., 98, 3375, 10.1073/pnas.051014398
Willy, 1995, LXR, a nuclear receptor that defines a distinct retinoid response pathway, Genes Dev., 9, 1033, 10.1101/gad.9.9.1033
Repa, 2000, The role of orphan nuclear receptors in the regulation of cholesterol homeostasis, Annu. Rev. Cell Dev. Biol., 16, 459, 10.1146/annurev.cellbio.16.1.459
Janowski, 1999, Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta, Proc. Natl. Acad. Sci. USA., 96, 266, 10.1073/pnas.96.1.266
Forman, 1995, Identification of a nuclear receptor that is activated by farnesol metabolites, Cell, 81, 687, 10.1016/0092-8674(95)90530-8
Seol, 1995, Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors, Mol. Endocrinol., 9, 72
Edwards, 1999, Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway, Annu. Rev. Biochem., 68, 157, 10.1146/annurev.biochem.68.1.157
Grober, 1999, Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer, J. Biol. Chem., 274, 29749, 10.1074/jbc.274.42.29749
Laffitte, 2000, Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor, J Biol Chem., 275, 10638, 10.1074/jbc.275.14.10638
Kast, 2001, Regulation of multidrug resistance-associated protein 2 (MRP2; ABCC2) by the nuclear receptors PXR, FXR, and CAR, J. Biol. Chem.
Howard, 2000, Catabolites of cholesterol synthesis pathways and forskolin as activators of the farnesoid X-activated nuclear receptor, Toxicol. Appl. Pharmacol., 163, 195, 10.1006/taap.1999.8869
Kliewer, 2002, Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor, J. Lipid Res., 10.1016/S0022-2275(20)30141-3
Kliewer, 1999, Orphan nuclear receptors: shifting endocrinology into reverse, Science, 284, 757, 10.1126/science.284.5415.757
Xie, 2001, Orphan nuclear receptors: the exotics of xenobiotics, J. Biol. Chem., 276, 37739, 10.1074/jbc.R100033200
Bertilsson, 1998, Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction, Proc. Natl. Acad. Sci. USA., 95, 12208, 10.1073/pnas.95.21.12208
Blumberg, 1998, SXR, a novel steroid and xenobiotic-sensing nuclear receptor, Genes Dev., 12, 3195, 10.1101/gad.12.20.3195
Kliewer, 1998, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway, Cell, 92, 73, 10.1016/S0092-8674(00)80900-9
Lehmann, 1998, The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions, J. Clin. Invest., 102, 1016, 10.1172/JCI3703
Moore, 2000, St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor, Proc. Natl. Acad. Sci. USA., 97, 7500, 10.1073/pnas.130155097
Goodwin, 1999, The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module, Mol. Pharmacol., 56, 1329, 10.1124/mol.56.6.1329
Berge, 2000, Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters, Science, 290, 1771, 10.1126/science.290.5497.1771
Lee, 2001, Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption, Nat. Genet., 27, 79, 10.1038/83799
Goldstein, 2001, Molecular medicine. The cholesterol quartet, Science, 292, 1310, 10.1126/science.1061815
Lu, 2001, Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively, Am. J. Hum. Genet., 69, 278, 10.1086/321294
Repa, 2000, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers, Science, 289, 1524, 10.1126/science.289.5484.1524
Lu, 2001, Dietary cholesterol absorption: more than just bile, Trends Endocrinol. Metab., 12, 314, 10.1016/S1043-2760(01)00433-7
Rust, 1999, Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1, Nat. Genet., 22, 352, 10.1038/11921
Brooks-Wilson, 1999, Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency, Nat. Genet., 22, 336, 10.1038/11905
Bodzioch, 1999, The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. [see comments], Nat. Genet., 22, 347, 10.1038/11914
McNeish, 2000, High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1, Proc. Natl. Acad. Sci. USA., 97, 4245, 10.1073/pnas.97.8.4245
Orsó, 2000, Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice, Nat. Genet., 24, 192, 10.1038/72869
Christiansen-Weber, 2000, Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency, Am. J. Pathol., 157, 1017, 10.1016/S0002-9440(10)64614-7
Drobnik, 2001, ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism, Gastroenterology, 120, 1203, 10.1053/gast.2001.23250
Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4
Russell, 1999, Nuclear orphan receptors control cholesterol catabolism, Cell, 97, 539, 10.1016/S0092-8674(00)80763-1
Repa, 2000, Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta, Genes Dev., 14, 2819, 10.1101/gad.844900
Alberti, 2001, Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice, J. Clin. Invest., 107, 565, 10.1172/JCI9794
Chang, 2001, Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis, J. Lipid Res., 42, 1933, 10.1016/S0022-2275(20)31521-2
Yoshikawa, 2001, Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter, Mol. Cell Biol., 21, 2991, 10.1128/MCB.21.9.2991-3000.2001
DeBose-Boyd, 2001, Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands, Proc. Natl. Acad. Sci. USA., 98, 1477, 10.1073/pnas.98.4.1477
Edwards, 2000, Regulation of gene expression by SREBP and SCAP, Biochim. Biophys. Acta., 1529, 103, 10.1016/S1388-1981(00)00140-2
Kast, 2001, CTP:phosphocholine cytidylyltransferase, a new sterol and SREBP-responsive gene, J. Lipid Res., 42, 1266, 10.1016/S0022-2275(20)31577-7
Osborne, 2000, Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action, J. Biol. Chem., 275, 32379, 10.1074/jbc.R000017200
Goodwin, 2000, A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis, Mol. Cell., 6, 517, 10.1016/S1097-2765(00)00051-4
Lu, 2000, Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors, Mol. Cell., 6, 507, 10.1016/S1097-2765(00)00050-2
Nitta, 1999, CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene, Proc. Natl. Acad. Sci. USA., 96, 6660, 10.1073/pnas.96.12.6660
del Castillo-Olivares, 2000, Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription, Nucleic Acids Res., 28, 3587, 10.1093/nar/28.18.3587
Miyake, 2000, Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase, J. Biol. Chem., 275, 21805, 10.1074/jbc.C000275200
Sinal, 2000, Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis, Cell, 102, 731, 10.1016/S0092-8674(00)00062-3
Ananthanarayanan, 2001, Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor, J. Biol. Chem., 276, 28857, 10.1074/jbc.M011610200
Childs, 1995, Identification of a sister gene to P-glycoprotein, Cancer Res., 55, 2029
Gerloff, 1998, The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver, J. Biol. Chem., 273, 10046, 10.1074/jbc.273.16.10046
Nelson, 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics, 6, 1, 10.1097/00008571-199602000-00002
Noé, 1997, Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain, Proc. Natl. Acad. Sci. USA., 94, 10346, 10.1073/pnas.94.19.10346
Reichel, 1999, Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver, Gastroenterology, 117, 688, 10.1016/S0016-5085(99)70463-4
Geick, 2001, Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin, J. Biol. Chem., 276, 14581, 10.1074/jbc.M010173200
Xie, 2000, Humanized xenobiotic response in mice expressing nuclear receptor SXR, Nature, 406, 435, 10.1038/35019116
Venkateswaran, 2000, Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha, Proc. Natl. Acad. Sci. USA., 97, 12097, 10.1073/pnas.200367697
Schwartz, 2000, ABC1 gene expression and apoA-I-mediated cholesterol efflux are regulated by LXR, Biochem. Biophys. Res. Commun., 274, 794, 10.1006/bbrc.2000.3243
Costet, 2000, Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor, J. Bio. Chem., 275, 28240, 10.1074/jbc.M003337200
Venkateswaran, 2000, Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols, J. Bio. Chem., 275, 14700, 10.1074/jbc.275.19.14700
Whitney, 2001, LXR regulation of the LXRa gene in human macrophages, J. Bio. Chem., 10.1074/jbc.M106155200
Laffitte, 2001, Autoregulation of the human LXRa promoter, Mol. Cell. Biol., 21, 7558, 10.1128/MCB.21.22.7558-7568.2001
Chawla, 2001, A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Mol. Cell., 7, 161, 10.1016/S1097-2765(01)00164-2
Tobin, 2000, Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptoralpha, Mol. Endocrinol., 14, 741
Chinetti, 2001, PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway, Nat. Med., 7, 53, 10.1038/83348
Santamarina-Fojo, 2001, Regulation and intracellular trafficking of the ABCA1 transporter, J. Lipid Res., 42, 1339, 10.1016/S0022-2275(20)30266-2
Oram, 2001, ABCA1: the gatekeeper for eliminating excess tissue cholesterol, J. Lipid Res., 42, 1173, 10.1016/S0022-2275(20)31566-2
Bortnick, 2000, The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines, J. Biol. Chem., 275, 28634, 10.1074/jbc.M003407200
Remaley, 2001, Apolipoprotein specificity for lipid efflux by the human ABCAI transporter, Biochem. Biophys. Res. Commun., 280, 818, 10.1006/bbrc.2000.4219
Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc. Natl. Acad. Sci. USA., 98, 507, 10.1073/pnas.98.2.507
Fielding, 2000, A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1, Biochemistry, 39, 14113, 10.1021/bi0004192
Wang, 2001, ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein, J. Biol. Chem., 276, 23742, 10.1074/jbc.M102348200
Chen, 2001, Preferential ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux from late endosomes/lysosomes, J. Biol. Chem., 276, 43564, 10.1074/jbc.M107938200
Oram, 1991, High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts, Arterioscler. Thromb., 11, 403, 10.1161/01.ATV.11.2.403
Singaraja, 2001, Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and apoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1, J. Biol. Chem., 10.1074/jbc.M102503200
Klucken, 2000, ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport, Proc. Natl. Acad. Sci. USA., 97, 817, 10.1073/pnas.97.2.817
Von Eckardstein, 2001, ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages, FASEB J., 15, 1555, 10.1096/fj.00-0798com
Kennedy, 2001, Characterization of the human ABCG1 Gene: LXR activates an internal promoter that produces a novel transcript encoding an alternative form of the protein, J. Biol. Chem., 276, 39438, 10.1074/jbc.M105863200
Lorkowski, 2001, Genomic sequence and structure of the human ABCG1 (ABC8) gene, Biochem. Biophys. Res. Commun., 280, 121, 10.1006/bbrc.2000.4089
Luo, 2000, Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element, J. Clin. Invest., 105, 513, 10.1172/JCI8573
Zhang, 2001, Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta, J. Biol. Chem., 276, 43018, 10.1074/jbc.M107823200
Kast, 2001, Activated FXR induces apoC-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids, Mol. Endocrinol., 15, 1720, 10.1210/mend.15.10.0712
Urizar, 2000, The farne-soid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression, J. Biol. Chem., 275, 39313, 10.1074/jbc.M007998200
Jiang, 1999, Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels, J. Clin. Invest., 103, 907, 10.1172/JCI5578
Allan, 1995, Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice, J. Biol. Chem., 270, 26278, 10.1074/jbc.270.44.26278
Allan, 1997, Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster, J. Biol. Chem., 272, 29113, 10.1074/jbc.272.46.29113