Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct—an immunohistochemical study of 110 cases of hepatolithiasis

Okuda, 2002, Cholangiocarcinoma: recent progress. Part 1: epidemiology and etiology, J Gastroenterol Hepatol, 17, 1049, 10.1046/j.1440-1746.2002.02781.x Patel, 2001, Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States, Hepatology, 33, 1353, 10.1053/jhep.2001.25087 Martin, 2003, Intrahepatic cholangiocarcinoma. Current management, Minerva Chir, 58, 469 Shimonishi, 2000, Precancerous lesions of intrahepatic cholangiocarcinoma, J Hepatobiliary Pancreat Surg, 7, 542, 10.1007/s005340070002 Nakanuma, 2003, Anatomic and molecular pathology of intrahepatic cholangiocarcinoma, J Hepatobiliary Pancreat Surg, 10, 265, 10.1007/s00534-002-0729-3 Nakanuma, 2000, Intrahepatic cholangiocarcinoma, 237 Chen, 2001, Intraductal papillary neoplasia of the liver associated with hepatolithiasis, Hepatology, 34, 651, 10.1053/jhep.2001.28199 Nakanuma, 2002, Biliary papillary neoplasm of the liver, Histol Histopathol, 17, 851 Bergquist, 2001, Biliary dysplasia, cell proliferation and nuclear DNA-fragmentation in primary sclerosing cholangitis with and without cholangiocarcinoma, J Intern Med, 249, 69, 10.1046/j.1365-2796.2001.00775.x Shimonishi, 2002, Increasing expression of gastrointestinal phenotypes and p53 along with histologic progression of intraductal papillary neoplasia of the liver, Hum Pathol, 33, 503, 10.1053/hupa.2002.124030 Nakanuma, 1997, Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply, Microsc Res Tech, 38, 552, 10.1002/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H Zen, 2005, Proposal of histologic criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: a preliminary report based on interobserver agreement, Pathol Int, 55, 180, 10.1111/j.1440-1827.2005.01816.x Longnecker, 2000, Intraductal papillary-mucinous neoplasms of the pancreas, 237 Liver Cancer Study Group of Japan, 2000 2002 Adsay, 2002, The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis, Mod Pathol, 15, 1087, 10.1097/01.MP.0000028647.98725.8B Kim, 2002, Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas, Gastroenterology, 123, 1052, 10.1053/gast.2002.36018 Sasaki, 1998, Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction, Hepatology, 27, 54, 10.1002/hep.510270110 Zen, 2002, Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis, Am J Pathol, 161, 1475, 10.1016/S0002-9440(10)64423-9 Shibahara, 2004, Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms, Am J Surg Pathol, 28, 327, 10.1097/00000478-200403000-00005 Luttges, 2003, Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable, Mod Pathol, 16, 537, 10.1097/01.MP.0000072748.65178.2F Handra-Luca, 2004, Correlation between patterns of DNA mismatch repair hmlh1 and hmsh2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas, Virchows Arch, 444, 235, 10.1007/s00428-003-0966-0 Abraham, 2003, Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract, Hum Pathol, 34, 902, 10.1016/S0046-8177(03)00337-X Yonezawa, 1999, Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor, Pathol Int, 49, 45, 10.1046/j.1440-1827.1999.00823.x Yonezawa, 2002, The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms, J Hepatobiliary Pancreat Surg, 9, 328, 10.1007/s005340200037 Luttges, 2001, The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma, Am J Surg Pathol, 25, 942, 10.1097/00000478-200107000-00014