Influence of lipolysis on drug absorption from the gastro-intestinal tract

Advanced Drug Delivery Reviews - Tập 25 - Trang 33-46 - 1997
Karen J. MacGregor1, Jonathan K. Embleton1, Jon E. Lacy1, E.Anne Perry1, Linda J. Solomon2, Harry Seager3, Colin W. Pouton2
1R P Scherer Ltd., Frankland Road, Blagrove, Swindon SN5 8YS, UK
2School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
3Scherer DDS, Frankland Road, Blagrove, Swindon SN8 8RU, UK

Tài liệu tham khảo

Humberstone, 1996, Lipid-based vehicles for the oral delivery of poorly water-soluble drugs, Adv. Drug Delivery Rev. Yamahira, 1978, Biopharmaceutical studies of lipid-containing oral dosage forms: relationship between drug absorption and gastric emptying of lipid formulations, J. Pharmacobiol. Dyn., 1, 160, 10.1248/bpb1978.1.160 Welling, 1989, The effects of food on drug absorption, Pharmacol. Ther., 43, 425, 10.1016/0163-7258(89)90019-3 Gibaldi, 1970, Mechanism of surfactant effects on drug absorption, J. Pharm. Sci., 55, 191 O'Driscoll, 1996, Micellar solubilization/self-emulsifying systems for improved absorption of drugs, 126 Carey, 1972, Micelle formation by bile salts. Physical-chemical and thermodynamic considerations, Arch. Intern. Med., 130, 506, 10.1001/archinte.130.4.506 Tso, 1985, Gastrointestinal digestion and absorption of lipid, Adv. Lipid Res., 21, 143, 10.1016/B978-0-12-024921-3.50011-3 O'Connor, 1985, Physical-chemical behavior of bile salts, Adv. Coll. Interface Sci, 22, 1, 10.1016/0001-8686(85)80002-6 Bakatselou, 1991, Solubilization and wetting effects of bile salts on the dissolution of steroids, Pharm. Res., 8, 1461, 10.1023/A:1015877929381 Naylor, 1995, Dissolution of steroids in bile salt solutions is modified by the presence of lecithin, Eur. J. Pharm. Biopharm., 41, 346 Mithani, 1996, Estimation of the increase in solubility as a function of bile salt concentration, Pharm. Res., 13, 163, 10.1023/A:1016062224568 Li, 1996, Solubilization of retinoids by bile salt/phospholipid aggregates, Pharm. Res., 13, 907, 10.1023/A:1016013414457 Solomon, 1996, Solubilization of steroidal compounds by mixed bile salt/ lecithin micelles, 219 Patton, 1985, The light microscopy of triglyceride digestion, Food Microstructure, 4, 29 Ptachcinsky, 1986, Clinical pharmacokinetics of cyclosporin, Clin. Pharmacokinet., 11, 107, 10.2165/00003088-198611020-00002 Kovarik, 1994, Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation, J. Pharm. Sci., 83, 444, 10.1002/jps.2600830336 Loper, 1996, Equivalence of a self-emulsifying drug delivery system (SEDDS) and soybean oil for oral delivery of a 5α-reductase inhibitor in rhesus monkeys, 369 Borgstrom, 1984, Pancreatic Colipase, 151 Embleton, 1996, Structure and function of gastro-intestinal lipases, Adv. Drug Delivery Rev. Alvarez, 1989, The role of calcium ions and BS on the pancreatic lipase-catalyzed hydrolysis of triglyceride emulsions stabilized with lecithin, Pharm. Res., 6, 449, 10.1023/A:1015956104500 van Tilbeurgh, 1992, Structure of the pancreatic lipase-colipase complex, Nature, 359, 159, 10.1038/359159a0 Staggers, 1990, Physical-chemical behaviour of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behaviour and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings, Biochemistry, 29, 2028, 10.1021/bi00460a011 Hernell, 1990, Physical-chemical behaviour of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase behaviour and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings, Biochemistry, 29, 2041, 10.1021/bi00460a012 Challis, 1991, Physicochemical and biopharmaceutical studies of novel self-emulsifying systems for administration by the oral route Larsson, 1986, Effect of phosphatidylcholine and free fatty acids on the activity of pancreatic lipase-colipase, Biochim. Biophys. Acta, 876, 543, 10.1016/0005-2760(86)90042-1 Pouton, 1996, Formulation of self-emulsifying drug delivery systems, Adv. Drug Delivery Rev. Solomon, 1996, Inhibition of lipolysis of medium-chain triglycerides by nonionic surfactants, a structure/activity study, 437