Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT 6 receptor antagonists. Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry - Tập 124 - Trang 63-81 - 2016
Anna Więckowska1, Marcin Kołaczkowski2, Adam Bucki2, Justyna Godyń1, Monika Marcinkowska2, Krzysztof Więckowski3, Paula Zaręba1, Agata Siwek4, Grzegorz Kazek5, Monika Głuch-Lutwin4, Paweł Mierzejewski6, Przemysław Bienkowski6, Halina Sienkiewicz-Jarosz6, Damijan Knez7, Tomasz Wichur1, Stanislav Gobec7, Barbara Malawska1
1Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna Str., 30-688, Kraków, Poland
2Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna Str., 30-688, Kraków, Poland
3Department of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna Str., 30-688, Kraków, Poland
4Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna Str., 30-688, Kraków, Poland
5Department of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, 9 Medyczna Str., 30-688, Kraków, Poland
6Institute of Psychiatry and Neurology, 9 Sobieskiego Str., 02-957, Warsaw, Poland
7Faculty of pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia

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