Mammalian autophagy: core molecular machinery and signaling regulation

Current Opinion in Cell Biology - Tập 22 - Trang 124-131 - 2010
Zhifen Yang1, Daniel J Klionsky1,2
1Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA
2Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109-2216, USA

Tài liệu tham khảo

Klionsky, 2005, The molecular machinery of autophagy: unanswered questions, J Cell Sci, 118, 7, 10.1242/jcs.01620 Massey, 2006, Chaperone-mediated autophagy in aging and disease, Curr Top Dev Biol, 73, 205, 10.1016/S0070-2153(05)73007-6 Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639 Yang, 2009, An overview of the molecular mechanism of autophagy, Curr Top Microbiol Immunol, 335, 1 Xie, 2007, Autophagosome formation: core machinery and adaptations, Nat Cell Biol, 9, 1102, 10.1038/ncb1007-1102 Jung, 2009, ULK–Atg13–FIP200 complexes mediate mTOR signaling to the autophagy machinery, Mol Biol Cell, 20, 1992, 10.1091/mbc.E08-12-1249 Kundu, 2008, Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation, Blood, 112, 1493, 10.1182/blood-2008-02-137398 Young, 2009, Autophagy mediates the mitotic senescence transition, Genes Dev, 23, 798, 10.1101/gad.519709 Kamada, 2000, Tor-mediated induction of autophagy via an Apg1 protein kinase complex, J Cell Biol, 150, 1507, 10.1083/jcb.150.6.1507 Ganley, 2009, ULK1·ATG13·FIP200 complex mediates mTOR signaling and is essential for autophagy, J Biol Chem, 284, 12297, 10.1074/jbc.M900573200 Hosokawa, 2009, Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required for autophagy, Mol Biol Cell, 20, 1981, 10.1091/mbc.E08-12-1248 Hara, 2008, FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells, J Cell Biol, 181, 497, 10.1083/jcb.200712064 Mercer, 2009, A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy, Autophagy, 5, 649, 10.4161/auto.5.5.8249 Fujita, 2008, The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy, Mol Biol Cell, 19, 2092, 10.1091/mbc.E07-12-1257 Hanada, 2007, The Atg12–Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy, J Biol Chem, 282, 37298, 10.1074/jbc.C700195200 Sou, 2008, The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice, Mol Biol Cell, 19, 4762, 10.1091/mbc.E08-03-0309 Fujita, 2008, An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure, Mol Biol Cell, 19, 4651, 10.1091/mbc.E08-03-0312 Itakura, 2008, Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG, Mol Biol Cell, 19, 5360, 10.1091/mbc.E08-01-0080 Sun, 2008, Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase, Proc Natl Acad Sci U S A, 105, 19211, 10.1073/pnas.0810452105 Liang, 2006, Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG, Nat Cell Biol, 8, 688, 10.1038/ncb1426 Matsunaga, 2009, Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages, Nat Cell Biol, 11, 385, 10.1038/ncb1846 Zhong, 2009, Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex, Nat Cell Biol, 11, 468, 10.1038/ncb1854 Takahashi, 2007, Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis, Nat Cell Biol, 9, 1142, 10.1038/ncb1634 Takahashi, 2009, Bif-1/endophilin B1: a candidate for crescent driving force in autophagy, Cell Death Differ, 16, 947, 10.1038/cdd.2009.19 Liang, 2008, Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking, Nat Cell Biol, 10, 776, 10.1038/ncb1740 Fimia, 2007, Ambra1 regulates autophagy and development of the nervous system, Nature, 447, 1121, 10.1038/nature05925 Young, 2006, Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes, J Cell Sci, 119, 3888, 10.1242/jcs.03172 Reggiori, 2004, The Atg1–Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure, Dev Cell, 6, 79, 10.1016/S1534-5807(03)00402-7 Ropolo, 2007, The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells, J Biol Chem, 282, 37124, 10.1074/jbc.M706956200 Calvo-Garrido, 2008, Vacuole membrane protein 1 is an endoplasmic reticulum protein required for organelle biogenesis, protein secretion, and development, Mol Biol Cell, 19, 3442, 10.1091/mbc.E08-01-0075 Nowak, 2009, The TP53INP2 protein is required for autophagy in mammalian cells, Mol Biol Cell, 20, 870, 10.1091/mbc.E08-07-0671 Codogno, 2005, Autophagy and signaling: their role in cell survival and cell death, Cell Death Differ, 12, 1509, 10.1038/sj.cdd.4401751 Zeng, 2008, Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy, Cancer Res, 68, 2384, 10.1158/0008-5472.CAN-07-6163 Thoreen, 2009, An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1, J Biol Chem, 284, 8023, 10.1074/jbc.M900301200 Inoki, 2002, TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling, Nat Cell Biol, 4, 648, 10.1038/ncb839 Ma, 2005, Phosphorylation and functional inactivation of TSC2 by Erk: implications for tuberous sclerosis and cancer pathogenesis, Cell, 121, 179, 10.1016/j.cell.2005.02.031 Furuta, 2004, Ras is involved in the negative control of autophagy through the class I PI3-kinase, Oncogene, 23, 3898, 10.1038/sj.onc.1207539 Pattingre, 2003, Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells, J Biol Chem, 278, 16667, 10.1074/jbc.M210998200 Sarbassov, 2005, Phosphorylation and regulation of Akt/PKB by the rictor–mTOR complex, Science, 307, 1098, 10.1126/science.1106148 Mammucari, 2007, FoxO3 controls autophagy in skeletal muscle in vivo, Cell Metab, 6, 458, 10.1016/j.cmet.2007.11.001 Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol Cell, 30, 214, 10.1016/j.molcel.2008.03.003 Liang, 2007, The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis, Nat Cell Biol, 9, 218, 10.1038/ncb1537 Høyer-Hansen, 2007, Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2, Mol Cell, 25, 193, 10.1016/j.molcel.2006.12.009 Herrero-Martin, 2009, TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells, EMBO J, 28, 677, 10.1038/emboj.2009.8 Papandreou, 2008, Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L, Cell Death Differ, 15, 1572, 10.1038/cdd.2008.84 Levine, 2008, p53: the Janus of autophagy?, Nat Cell Biol, 10, 637, 10.1038/ncb0608-637 Feng, 2005, The coordinate regulation of the p53 and mTOR pathways in cells, Proc Natl Acad Sci U S A, 102, 8204, 10.1073/pnas.0502857102 Crighton, 2006, DRAM, a p53-induced modulator of autophagy, is critical for apoptosis, Cell, 126, 121, 10.1016/j.cell.2006.05.034 Tasdemir, 2008, Regulation of autophagy by cytoplasmic p53, Nat Cell Biol, 10, 676, 10.1038/ncb1730 Morselli, 2008, Mutant p53 protein localized in the cytoplasm inhibits autophagy, Cell Cycle, 7, 3056, 10.4161/cc.7.19.6751 Levine, 2008, Bcl-2 family members: dual regulators of apoptosis and autophagy, Autophagy, 4, 600, 10.4161/auto.6260 Maiuri, 2007, Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1, EMBO J, 26, 2527, 10.1038/sj.emboj.7601689 Wei, 2008, JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy, Mol Cell, 30, 678, 10.1016/j.molcel.2008.06.001 Zalckvar, 2009, DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy, EMBO Rep, 10, 285, 10.1038/embor.2008.246