The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Aktories, 1989, The rho gene product expressed in E. coli is a substrate for botulinum ADP-ribosyltransferase C3, Biochem. Biophys. Res. Commun., 158, 209, 10.1016/S0006-291X(89)80199-8 Balch, 1990, Small GTP-binding proteins in vesicular transport, Trends Biochem. Sci., 15, 473, 10.1016/0968-0004(90)90301-Q Benton, 1982, Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?, Blood, 60, 642, 10.1182/blood.V60.3.642.642 Bockus, 1984, Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor, Exp. Cell Res., 153, 186, 10.1016/0014-4827(84)90460-9 Bos, 1988, The ras gene family and human carcinogenesis, Mutation Res., 195, 255, 10.1016/0165-1110(88)90004-8 Bretscher, 1991, Microfilament structure and function in the cortical cytoskeleton, Annu. Rev. Cell Biol., 7, 337, 10.1146/annurev.cb.07.110191.002005 Burridge, 1988, Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton, Annu. Rev. Cell Biol., 4, 487, 10.1146/annurev.cb.04.110188.002415 Chardin, 1989, The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells, EMBO J., 8, 1087, 10.1002/j.1460-2075.1989.tb03477.x Chen, 1975, Mitogenic activity of blood components. I. Thrombin and prothrombin, 72, 131 DePasquale, 1987, Evidence for an actin-containing precursor of the focal contact and the timing of incorporation of vinculin at the focal contact, J. Cell Biol., 105, 2803, 10.1083/jcb.105.6.2803 DePasquale, 1991, Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts, J. Cell Biol., 113, 1352, 10.1083/jcb.113.6.1351 Devreotes, 1988, Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium, Annu. Rev. Cell Biol., 4, 649, 10.1146/annurev.cb.04.110188.003245 Didsbury, 1989, Rac, a novel ras-related family of proteins that are botulinum toxin substrates, J. Biol. Chem., 264, 16378, 10.1016/S0021-9258(19)84716-6 Diekmann, 1991, Bcr encodes a GTPase activating protein for p21rac, Nature, 351, 400, 10.1038/351400a0 Downward, 1990, The ras superfamily of small GTP-binding proteins, Trends Biochem. Sci., 15, 469, 10.1016/0968-0004(90)90300-Z Fukumoto, 1990, Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins, Oncogene, 5, 1321 Garrett, 1989, Identification of distinct cytoplasmic targets for rasR-ras and rho regulatory proteins, J. Biol. Chem., 264, 10, 10.1016/S0021-9258(17)31215-2 Garrett, 1991, Purification and N-terminal sequence of the p21rho GTPase activating protein, rho-GAP, Biochem. J., 276, 833, 10.1042/bj2760833 Gerrard, 1984, Lysophosphatidic acid can activate platelets without increasing 32P-labelling of phosphatidic acid, Biochim. Biophys. Acta, 795, 487, 10.1016/0005-2760(84)90177-2 Gerrard, 1989, Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin, Biochim. Biophys. Acta, 1001, 282, 10.1016/0005-2760(89)90112-4 Greenberg, 1991, Ca2+-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages, J. Cell Biol., 113, 757, 10.1083/jcb.113.4.757 Hall, 1990, The cellular function of small GTP-binding proteins, Science, 249, 635, 10.1126/science.2116664 Hall, 1986, The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras, J. Biol. Chem., 261, 10963, 10.1016/S0021-9258(18)67333-8 Hall, 1989, Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation, J. Cell Biol., 109, 2207, 10.1083/jcb.109.5.2207 Herman, 1985, Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALBc-3T3 cells, J. Cell Biol., 100, 1031, 10.1083/jcb.100.4.1031 Hiraoka, 1992, Both stimulatory and inhibitory GDPGTP exchange proteins, smgGDS and rhoGDI, are active on multiple small GTP-binding proteins, Biochem. Biophys. Res. Commun., 182, 921, 10.1016/0006-291X(92)91820-G Isomura, 1990, Partial purification and characterization of GDP dissociation stimulator (GDS) for the rho proteins from bovine brain cytosol, Biochem. Biophys. Res. Commun., 169, 652, 10.1016/0006-291X(90)90380-6 Jalink, 1990, Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2+-mobilizing stimulus for fibroblasts, J. Biol. Chem., 265, 12232, 10.1016/S0021-9258(19)38335-8 Jennings, 1981, Changes in the cytoskeletal structure of human platelets following thrombin activation, J. Biol. Chem., 256, 6927, 10.1016/S0021-9258(19)69080-0 Johnson, 1990, Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity, J. Cell Biol., 111, 143, 10.1083/jcb.111.1.143 Kadowaki, 1986, Insulin-like growth factors, insulin and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells, J. Biol. Chem., 261, 16141, 10.1016/S0021-9258(18)66689-X Kahn, 1991, Human ADP-ribosylation factors, J. Biol. Chem., 266, 2606, 10.1016/S0021-9258(18)52288-2 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of the bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Lapetina, 1981, The phosphatidylinositol cycle and the regulation of arachidonic acid production, Nature, 292, 373, 10.1038/292367a0 Mellström, 1983, The effect of platelet-derived growth factor on morphology and motility of human glial cells, J. Muscle Res. Cell Motil., 4, 589, 10.1007/BF00712117 Mellström, 1988, Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor, Exp. Cell Res., 177, 347, 10.1016/0014-4827(88)90468-5 Mizuno, 1991, A stimulatory GDPGTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21, 88, 6442 Paterson, 1990, Microinjection of recombinant p21rho induces rapid changes in cell morphology, J. Cell Biol., 111, 1001, 10.1083/jcb.111.3.1001 Ridley, 1992, The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling, Cell, 70, 10.1016/0092-8674(92)90164-8 Rubin, 1988, Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum, Mol. Cell. Biol., 8, 418, 10.1128/MCB.8.1.418 Salmon, 1989, Cytokinesis in animal cells, Curr. Opin. Cell Biol., 1, 541, 10.1016/0955-0674(89)90018-5 Sekine, 1989, Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase, J. Biol. Chem., 264, 8602, 10.1016/S0021-9258(18)81834-8 Serafini, 1991, ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein, Cell, 67, 239, 10.1016/0092-8674(91)90176-Y Sha'afi, 1986, Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin?, J. Cell Biol., 102, 1459, 10.1083/jcb.102.4.1459 Shinjo, 1990, Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42, 87, 9853 Small, 1988, The actin cytoskeleton, Electron Microsc. Rev., 1, 155, 10.1016/S0892-0354(98)90010-7 Smith, 1988, Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene, 67, 31, 10.1016/0378-1119(88)90005-4 Stossel, 1989, From signal to pseudopod, J. Biol. Chem., 264, 18261, 10.1016/S0021-9258(18)51454-X Switzer, 1965, Transport of lysolecithin by albumin in human and rat plasma, J. Lipid Res., 6, 506, 10.1016/S0022-2275(20)39614-0 Tsai, 1989, Inhibition by phospholipids of the interaction between R-ras, rho and their GTPase-activating proteins, Mol. Cell. Biol., 9, 5260, 10.1128/MCB.9.11.5260 Turner, 1991, Transmembrane molecular assemblies in cell-extracellular matrix interactions, Curr. Opin. Cell Biol., 3, 849, 10.1016/0955-0674(91)90059-8 van Corven, 1989, Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins, Cell, 59, 45, 10.1016/0092-8674(89)90868-4 Wang, 1984, Reorganization of actin filament bundles in living fibroblasts, J. Cell Biol., 99, 1478, 10.1083/jcb.99.4.1478