Lipid A Acylation and Bacterial Resistance against Vertebrate Antimicrobial Peptides

Alpuche-Aranda, 1992, Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes, Proc. Natl. Acad. Sci. USA, 89, 10079, 10.1073/pnas.89.21.10079 Altschul, 1990, Basic local alignment search tool, J. Mol. Biol., 215, 403, 10.1016/S0022-2836(05)80360-2 Bechinger, 1997, Structure and functions of channel-forming peptides, J. Membr. Biol., 156, 197, 10.1007/s002329900201 Belden, 1994, Further characterization of the PhoP regulon, Infect. Immun., 62, 5095, 10.1128/IAI.62.11.5095-5101.1994 Caroff, 1988, Detergent-accelerated hydrolysis of bacterial endotoxins and determination of the anomeric configuration of the glycosyl phosphate present in the “isolated lipid A” fragment of the Bordetella pertusis endotoxin, Carbohydr. Res., 175, 273, 10.1016/0008-6215(88)84149-1 Darveau, 1983, Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains, J. Bacteriol., 155, 831, 10.1128/JB.155.2.831-838.1983 Darveau, 1991, Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo, Antimicrob. Agents Chemother., 35, 1153, 10.1128/AAC.35.6.1153 Darveau, 1992, Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity, J. Clin. Invest., 90, 447, 10.1172/JCI115880 Davies, 1994, Inactivation of antibiotics and the dissemination of resistance genes, Science, 264, 375, 10.1126/science.8153624 Elliott, 1988, Characterization of Tn 10d-Cam, Mol. Gen. Genet., 213, 332, 10.1007/BF00339599 Fields, 1989, A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells, Science, 243, 1059, 10.1126/science.2646710 Fu, 1991, Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli, Gene, 100, 195, 10.1016/0378-1119(91)90366-J Gabay, 1994, Ubiquitous natural antibiotics, Science, 264, 373, 10.1126/science.8153623 Garcia-Vescovi, 1996, Mg2+ as an extracellular signal, Cell, 84, 165, 10.1016/S0092-8674(00)81003-X Goldman, 1997, Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis, Cell, 88, 553, 10.1016/S0092-8674(00)81895-4 Groisman, 1992, Resistance to host antimicrobial peptides is necessary for Salmonella virulence, Proc. Natl. Acad. Sci. USA, 89, 11939, 10.1073/pnas.89.24.11939 Gunn, 1996, PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance, J. Bacteriol., 178, 6857, 10.1128/jb.178.23.6857-6864.1996 Gunn, 1995, Characterization of the S. typhimurium pagC/pagD chromosomal region, J. Bacteriol., 177, 5040, 10.1128/jb.177.17.5040-5047.1995 Gunn, 1998, PmrA-PmrB regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance, Mol. Microbiol., 27, 1171, 10.1046/j.1365-2958.1998.00757.x Gunn, 1998, Identification of PhoP-PhoQ activated genes within a duplicated region of the Salmonella typhimurium chromosome, Microb. Pathog., in press Guo, 1997, Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ, Science, 276, 250, 10.1126/science.276.5310.250 Guzman, 1995, Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter, J. Bacteriol., 177, 4121, 10.1128/jb.177.14.4121-4130.1995 Hancock, 1998, Cationic peptides, Trends Biotechnol., 16, 82, 10.1016/S0167-7799(97)01156-6 Heithoff, 1997, Bacterial infection as assessed by in vivo gene expression, Proc. Natl. Acad. Sci. USA, 94, 934, 10.1073/pnas.94.3.934 Helander, 1994, Increased substitution of phosphate groups in lipopolysaccharides and lipid A of the polymyxin-resistant pmrA mutants of Salmonella typhimurium, Mol. Microbiol., 11, 481, 10.1111/j.1365-2958.1994.tb00329.x Hillenkamp, F. (1994). Matrix-assisted laser desorption ionization (MALDI). In Biological Mass Spectrometry: Present and Future, T. Matsuo, R.M. Caprioli, M.L. Gross, and Y. Seyama, eds. (Chichester, England: John Wiley and Sons Ltd.), pp. 101–118. Hohmann, 1996, Evaluation of a phoP/phoQ deleted, aroA deleted live oral S. typhi vaccine strain in human volunteers, Vaccine, 14, 19, 10.1016/0264-410X(95)00173-X Hu, 1996, Overproduction of three genes leads to camphor resistance and chromosome condensation in Escherichia coli, Genetics, 143, 1521, 10.1093/genetics/143.4.1521 Jacob, 1994, Potential therapeutic applications of magainins and other antimicrobial agents of animal origin, Ciba Found. Symp., 186, 197 Kleckner, 1991, Uses of transposons with emphasis on Tn10, Methods Enzymol., 204, 139, 10.1016/0076-6879(91)04009-D Maniatis, 1982 Martin, 1995, Defensins and other endogenous peptide antibiotics of vertebrates, J. Leukoc. Biol., 58, 128, 10.1002/jlb.58.2.128 Medzhitov, 1997, Innate immunity, Cell, 91, 295, 10.1016/S0092-8674(00)80412-2 Mekalanos, 1992, Environmental signals controlling expression of virulence determinants in bacteria, J. Bacteriol., 174, 1, 10.1128/jb.174.1.1-7.1992 Miller, 1990, Constitutive expression of the PhoP regulon attenuates Salmonella virulence and survival within macrophages, J. Bacteriol., 172, 2485, 10.1128/jb.172.5.2485-2490.1990 Miller, 1989, A two-component regulatory system (phoP/phoQ) controls Salmonella typhimurium virulence, Proc. Natl. Acad. Sci. USA, 86, 5054, 10.1073/pnas.86.13.5054 Miller, 1990, Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium, Infect. Immun., 58, 3706, 10.1128/IAI.58.11.3706-3710.1990 Murray, C.K., and Beckwith, J. (1996). Export of proteins to the cell envelope in Escherichia coli. In Escherichia coli and Salmonella, F.C. Neidhardt, R. Curtiss III, J.L. Ingraham, E.C.C. Lin, K.B. Low, B. Magasanik, W.S. Reznikoff, M. Riley, M. Schaechter, and H.E. Umbarger, eds. (Washington, D.C.: ASM Press), pp. 967–978. Raetz, C.R.H. (1996). Bacterial lipopolysaccharides: a remarkable family of bioactive macroamphiphiles. In Escherichia coli and Salmonella, F.C. Neidhardt, R. Curtiss III, J.L. Ingraham, E.C.C. Lin, K.B. Low, B. Magasanik, W.S. Reznikoff, M. Riley, M. Schaechter, and H.E. Umbarger, eds. (Washington, D.C.: ASM Press), pp. 1035–1063. Rana, 1990, Interactions between Salmonella typhimurium lipopolysaccharide and the antimicrobial peptide, magainin 2 amide, FEBS Lett., 261, 464, 10.1016/0014-5793(90)80616-Q Skorupski, 1996, Positive selection vectors for allelic exchange, Gene, 169, 47, 10.1016/0378-1119(95)00793-8 Smith, 1996, Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid, Cell, 85, 229, 10.1016/S0092-8674(00)81099-5 Somerville, 1996, A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide, J. Clin. Invest., 97, 359, 10.1172/JCI118423 Soravia, 1988, Antimicrobial properties of peptides from Xenopus granular gland secretions, FEBS Lett., 228, 337, 10.1016/0014-5793(88)80027-9 Steinberg, 1997, Protegrin-1, Antimicrob. Agents Chemother., 41, 1738, 10.1128/AAC.41.8.1738 Stolzenberg, 1997, Epithelial antibiotic induced in states of disease, Proc. Natl. Acad. Sci. USA, 94, 8686, 10.1073/pnas.94.16.8686 Vaara, 1993, Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium, Antimicrob. Agents. Chemother., 37, 2255, 10.1128/AAC.37.11.2255 Wang, 1998, Ionization within a cylindrical capacitor, Anal. Chem., 70, 205, 10.1021/ac971036l Xu, 1997, Mercaptobenzothiazoles, J. Am. Soc. Mass. Spectrom., 8, 116, 10.1016/S1044-0305(96)00233-4 Yost, 1990, Tandem mass spectrometry, Methods Enzymol., 193, 154, 10.1016/0076-6879(90)93415-H