MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells

Yanagisawa, 1988, A novel potent vasoconstrictor peptide produced by vascular endothelial cells, Nature, 332, 411, 10.1038/332411a0

Lerman, 1995, Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans, Circulation, 92, 2426, 10.1161/01.CIR.92.9.2426

Ito, 1991, Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes, Circ. Res., 69, 209, 10.1161/01.RES.69.1.209

Nagendran, 2013, Endothelin axis is upregulated in human and rat right ventricular hypertrophy, Circ. Res., 112, 347, 10.1161/CIRCRESAHA.111.300448

Horgan, 1991, Mechanism of endothelin-1-induced pulmonary vasoconstriction, Circ. Res., 69, 157, 10.1161/01.RES.69.1.157

Sedeek, 2003, Role of reactive oxygen species in endothelin-induced hypertension, Hypertension, 42, 806, 10.1161/01.HYP.0000084372.91932.BA

Boffa, 2001, Regression of renal vascular fibrosis by endothelin receptor antagonism, Hypertension, 37, 490, 10.1161/01.HYP.37.2.490

Albertini, 2003, Role of endothelin ETA receptors in sepsis-induced mortality, vascular leakage, and tissue injury in rats, Eur. J. Pharmacol., 474, 129, 10.1016/S0014-2999(03)02037-5

Anggrahini, 2009, Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation, Cardiovas. Res., 82, 143, 10.1093/cvr/cvp026

May, 1996, Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks, Pain, 67, 375, 10.1016/0304-3959(96)03137-5

Denton, 2006, Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions, Ann. Rheum. Dis., 65, 1336, 10.1136/ard.2005.048967

Browatzki, 2000, Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells, Basic Res. Cardiol., 95, 98, 10.1007/s003950050170

Sutcliffe, 2009, Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1, Brit. J. Pharmacol., 157, 436, 10.1111/j.1476-5381.2009.00143.x

Yang, 2004, Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice, Circulation, 109, 255, 10.1161/01.CIR.0000105701.98663.D4

Piechota, 2011, Influence of nuclear factor-kappaB inhibition on endothelin-1 induced lung edema and oxidative stress in rats, J. Physiol. Pharmacol., 62, 183

Bode, 2005, Inducible covalent posttranslational modification of histone H3, Sci. STKE, 2005, 10.1126/stke.2812005re4

Wang, 2012, MLL1, a H3K4 methyltransferase, regulates the TNFalpha-stimulated activation of genes downstream of NF-kappaB, J. Cell Sci., 125, 4058, 10.1242/jcs.103531

Fang, 2011, Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury, Circ. Res., 108, 797, 10.1161/CIRCRESAHA.111.240655

Hanna, 2009, Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase, J. Biol. Chem., 284, 23125, 10.1074/jbc.M109.019059

Zhang, 2007, A novel role of Brg1 in the regulation of SRF/MRTFA-dependent smooth muscle-specific gene expression, J. Biol. Chem., 282, 25708, 10.1074/jbc.M701925200

Lockman, 2007, The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression, Circ. Res., 101, e115, 10.1161/CIRCRESAHA.107.164178

Sun, 2006, Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function, Mol. Cell. Biol., 26, 5809, 10.1128/MCB.00024-06

Tian, 2013, Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice, Hepatology, 58, 576, 10.1002/hep.26207

Rosette, 1995, Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B, J. Cell Biol., 128, 1111, 10.1083/jcb.128.6.1111

Yang, 2013, Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1, Nucleic Acids Res., 41, 6005, 10.1093/nar/gkt311

Wu, 2008, Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS, Mol. Cell. Biol., 28, 7337, 10.1128/MCB.00976-08

Chen, 2013, Brahma-related gene 1 (Brg1) epigenetically regulates CAM activation during hypoxic pulmonary hypertension, Cardiovas. Res., 100, 363, 10.1093/cvr/cvt214

Fang, 2009, RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells, Nucleic Acids Res., 37, 4393, 10.1093/nar/gkp398

Fang, 2013, Proinflammatory stimuli engage brahma related gene 1 and brahma in endothelial injury, Circ. Res., 113, 986, 10.1161/CIRCRESAHA.113.301296

Shilatifard, 2012, The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis, Annu. Rev. Biochem., 81, 65, 10.1146/annurev-biochem-051710-134100

Ramirez-Carrozzi, 2006, Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response, Genes Dev., 20, 282, 10.1101/gad.1383206

Naito, 2009, BRG1 increases transcription of proinflammatory genes in renal ischemia, J. Am. Soc. Nephrol., 20, 1787, 10.1681/ASN.2009010118

He, 2012, Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes, Cell Cycle, 11, 617, 10.4161/cc.11.3.19115

Wang, 2002, Potentiation of serum response factor activity by a family of myocardin-related transcription factors, Proc. Natl. Acad. Sci. U.S.A., 99, 14855, 10.1073/pnas.222561499

Cen, 2003, Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes, Mol. Cell. Biol., 23, 6597, 10.1128/MCB.23.18.6597-6608.2003

Li, 2006, Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells, Mol. Cell. Biol., 26, 5797, 10.1128/MCB.00211-06

Olson, 2010, Linking actin dynamics and gene transcription to drive cellular motile functions, Nat. Rev. Mol. Cell. Biol., 11, 353, 10.1038/nrm2890

Xia, 2013, Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20, Immunity, 39, 470, 10.1016/j.immuni.2013.08.016

Austenaa, 2012, The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis, Immunity, 36, 572, 10.1016/j.immuni.2012.02.016

Xu, 2014, Transcriptional regulation of endothelial dysfunction in atherosclerosis: an epigenetic perspective, J. Biomed. Res., 28, 47, 10.7555/JBR.27.20130055

Stephan, 2004, Albumin stimulates the accumulation of extracellular matrix in renal tubular epithelial cells, Am. J. Nephrol., 24, 14, 10.1159/000075347

Wiggins, 2010, NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus, J. Am. Soc. Nephrol., 21, 587, 10.1681/ASN.2009060663

Wynn, 2013, Macrophage biology in development, homeostasis and disease, Nature, 496, 445, 10.1038/nature12034

Perez-Lluch, 2011, Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing, Nucleic Acids Res., 39, 4628, 10.1093/nar/gkq1322

Alexander, 2012, Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease, Annu. Rev. Physiol., 74, 13, 10.1146/annurev-physiol-012110-142315

Wang, 2012, Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A, J. Biol. Chem., 287, 28067, 10.1074/jbc.M112.379487

Azadani, 2012, Biomechanical comparison of human pulmonary and aortic roots, Eur. J. Cardio-Thoracic Surgery, 41, 1111, 10.1093/ejcts/ezr163

Frid, 1997, Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease, Arterioscler. Throm. Vasc. Biol., 17, 1203, 10.1161/01.ATV.17.7.1203

Heineke, 2006, Regulation of cardiac hypertrophy by intracellular signalling pathways, Nat. Rev. Mol. Cell. Biol., 7, 589, 10.1038/nrm1983