Hormonal and metabolic gender differences in a cohort of myotonic dystrophy type 1 subjects: a retrospective, case–control study

Journal of Endocrinological Investigation - Tập 43 Số 5 - Trang 663-675 - 2020
Matteo Spaziani1, Antonella Semeraro1, Elisabetta Bucci2, Fábio Rossi1, Matteo Garibaldi2, Maria Alessia Papassifachis1, Carlotta Pozza3, Antonella Anzuini1, Andrea Lenzi1, Giovanni Antonini2, A. Radicioni1
1Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
2Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Rome, Italy
3Centre for Rare Diseases, Policlinico Umberto I, Rome, Italy

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Harper PS (2001) Myotonic dystrophy. Monckton DG, London

Jansen G, Mahadevan M, Amemiya C, Wormskamp N, Segers B, Hendriks W, O’Hoy K, Baird S, Sabourin L, Lennon G (1992) Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs. Nat Genet 1(4):261–266

Udd B, Krahe R (2012) The myotonic dystrophies: molecular, clinical, and therapeutic challenges. Lancet Neurol 11(10):891–905

De Antonio M, Dogan C, Hamroun D, Mati M, Zerrouki S, Eymard B, Katsahian S, Bassez G, French A (2016) Unravelling the myotonic dystrophy type 1 clinical spectrum: a sytematic registry-based study with implications for disease clasification. Rev Neurol (Paris) 172(10):572–580

Stokes M, Varughese N, Iannaccone S, Castro D (2019) Clinical and genetic characteristics of childhood-onset myotonic dystrophy. Muscle Nerve 60(6):732–738

Miller JW, Urbinati CR, Teng-Umnuay P, Stenberg MG, Byrne BJ, Thornton C, Swanson MS (2000) Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy. EMBO 19(17):4439–4448

Taneja KL, McCurrach M, Schalling M, Housman D, Singer RH (1995) Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues. J Cell Biol 128(6):995–1002

Davis BM, McCurrach ME, Taneja KL, Singer RH, Housman DE (1997) Expansion of a CUG trinucleotide repeat in the 3′-untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc Natll Acad Sci 94:7388–7393

Czubak K, Sedehizadeh S, Kozlowski P, Wojciechowska M (2019) An overview of circular RNAs and their implications in myotonic dystrophy. Int J Mol Sci 20(18):4385. https://doi.org/10.3390/ijms20184385

Mastrogiacomo I, Pagani E, Novelli G, Angelini C, Gennarelli M, Menegazzo E, Bonanni G, Dallapiccola B (1994) Male hypogonadism in myotonic dystrophy is related to (CTG)n triplet mutation. J Endocrinol Invest 17(5):381–383

Vazquez JA, Pinies JA, Martul P, De los Rios A, Gatzambide S, Busturia MA (1990) Hypothalamic-pituitary-testicular function in 70 patients with myotonic dystrophy. J Endocrinol Invest 13(5):375–379

Kaminsky P, Pruna L (2012) A genetic systemic disease: clinical description of type 1 myotonic dystrophy in adults. Rev Med Interne 33(9):514–518

Shieh K, Gilchrist JM, Promrat K (2010) Frequency and predictors of nonalcoholic fatty liver disease in myotonic dystrophy. Muscle Nerve 41(2):197–201

Cruz Gùzman OR, Chávez García AL, Rodríguez-Cruz M (2012) Muscular dystrophies at different ages: metabolic and endocrine alterations. Int J Endocrinol 2012:485376

Roussel MP, Morin M, Gagnon C, Duchesne E (2019) What is known about the effects of exercise or training to reduce skeletal muscle impairments of patients with myotonic dystrophy type 1? A scopimg review. BMC Muscoloskelet Disord 20(1):101

Win AK, Perattur PG, Pulido JS, Pulido CM, Lindor NM (2012) Increased cancer risks in myotonic dystrophy. Mayo Clin Proc 87(2):130–135

Zmuda JM, Cauley JA, Kriska A, Glynn NW, Gutai JP, Kuller LH (1997) Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. Am J Epidemiol 146(8):609–617

Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86(2):724–731. https://doi.org/10.1210/jcem.86.2.7219

Spaziani M, Mileno B, Rossi F, Granato S, Tahani N, Anzuini A, Lenzi A, Radicioni AF (2018) Endocrine and metabolic evaluation of classic Klinefelter syndrome and high grade aneuploidies of sexual chromosomes with male phenotype: are they different clinical conditions? Eur J Endocrinol 178:1–10

Radicioni AF, Tahani N, Spaziani M, Anzuini A, Piccheri C, Semeraro A, Tarani L, Lenzi A (2013) Reference ranges for thyroid hormones in normal Italian children and adolescents and overweight adolescents. J Endocrinol Investig 36(5):326–330

Russ G, Bigorgne C, Royer B, Rouxel A, Bienvenu-Perrard M (2011) The thyroid imaging reporting and data system (TIRADS) for ultrasound of the thyroid. J Radiol 92(7–8):701–713

Daumerie C, Lannoy N, Squifflet JP, Verellen G, Verellen-Dumoulin C (1994) High CTG repeat number in nodular thyroid tissue from a myotonic dystrophy patient. J Med Genet 31(11):891–892

Van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW (2005) Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90(12):6403–6409

De Alfieri W, Nisticò F, Borgogni T, Riello F, Cellai F, Mori C, Nante N, Di Bari M (2013) Thyroid hormones as predictors of short- and long-term mortality in very old hospitalized patients. J Gerontol A Biol Sci Med Sci 68(9):1122–1128

Maia AL, Goemann IM, Meyer EL, Wajner SM (2011) Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinol 209(3):283–297

Pasqualetti G, Calsolaro V, Bernardini S, Linsalata G, Bigazzi R, Caraccio N, Monzani F (2018) Degree of peripheral thyroxin deiodination, frailty, and long-term survival in hospitalized older patients. J Clin Endocrinol Metab 103(5):1867–1876

Emerenziani GP, Izzo G, Vaccaro MG, Quattrone A, Lenzi A, Aversa A (2019) Gender difference and correlation between sexuality, thyroid hormones, cognitive, and physical functions in elderly fit. J Endocrinol Invest 42(6):699–707

Carter JN, Steinbeck KS (1985) Reduced adrenal androgens in patients with myotonic dystrophy. J Clin Endocrinol Metab 60(3):611–614

Johansson Ǻ, Carlström K, Ahrén B, Cederquist K, Krylborg E, Forsberg H, Olsson T (2000) Abnormal cytokine and adrenocortical hormone regulation in myotonic dystrophy. J Clin Endocrinol Metab 85(9):3169–3176

Johansson Ǻ, Andrew R, Forsberg H, Cederquist K, Walker BR, Olsson T (2001) Glucocorticoid metabolism and adrenocortical reactivity to ACTH in myotonic dystrophy. J Clin Endocrinol Metab 86(9):4276–4283

Ørngreen MC, Arlien-Søborg P, Duno M, Hertz JM, Vissing J (2012) Endocrine function in 97 patients with myotonic dystrophy type 1. J Neurol 259(5):912–920

Henriksen OA, Sundsfjord JA, Nyberg-Hansen R (1978) Evaluation of the endocrine functions in dystrophia myotonica. Acta Neurol Scand 58:178–189

May PB, Renny A, Bastek J, Giglio W, Schneider G, Ertel N (1980) Diminished prolactin reserve with myotonic dystrophy. J Endocrinol Invest 3(4):415–418

Canal N, Smirne S, Comi G, Guidobono F, Pecile A, Caviezel F (1982) Study on growth hormone and prolactin secretions in myotonic dystrophy. Acta Neurol Belg 82:178–184

Passeri E, Bugiardini E, Sansone VA, Pizzoccaro A, Fulceri C, Valaperta R, Borgato S, Costa E, Bandera F, Ambrosi B et al (2015) Gonadal failure is associated with visceral adiposity in myotonic dystrophies. Eur J Clin Invest 45(7):702–710

Pizzi A, Fusi S, Forti G, Marconi G (1985) Study of endocrine function in myotonic dystrophy. Ital J Neurol Sci 6(4):457–467

Mastrogiacomo I, Bonanni G, Menegazzo E, Santarossa C, Pagani E, Gennarelli M, Angelini C (1996) Clinical and hormonal aspects of male hypogonadism in myotonic dystrophy. Ital J Neurol Sci 17(1):59–65

Vasquez JA, Pinies JA, Martul P, De los Rios A, Gatzambide S, Busturia MA (1990) Hypotalamic-pituitary-testicular function in 70 patients with Myotonic Dystrophy. J Endocrinol Invest 13:375–379

Lou XY, Nishi Y, Haji M, Antoku Y, Tanaka S, Ikuyama S, Yanase T, Takayanagi R, Nawata H (1994) Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy. Fukuoka Igaku Zasshi 85(5):168–174

Francomano D, Greco EA, Lenzi A, Aversa A (2013) CAG repeat testing of androgen receptor polymorphism: is this necessary for the best clinical management of hypogonadism? J Sex Med 10(10):2373–2381

Kunej T, Teran N, Zorn B, Peterlin B (2004) CTG amplification in the DM1PK gene is not associated with idiopathic male subfertility. Hum Reprod 19(9):2084–2087

Francomano D, Fattorini G, Gianfrilli D, Paoli D, Sgrò P, Radicioni A, Romanelli F, Di Luigi L, Gandini L, Lenzi A, Aversa A (2016) Acute endothelial response to testosterone gel administration in men with severe hypogonadism and its relationship to androgen receptor polymorphism: a pilot study. J Endocrinol Invest 39(3):265–271

Antonini G, Clemenzi A, Bucci E, De Marco E, Morino S, Di Pasquale A, Latino P, Ruga G, Lenzi A, Vanacore N et al (2011) Hypogonadism in DM1 and its relationship to erectile dysfunction. J Neurol 258(7):1247–1253

Matsumura T, Iwahashi H, Funahasci T, Takahashi MP, Saito T, Yasui K, Saito T, Iyama A, Toyooka K, Fujimura H et al (2009) A cross sectional study for glucose intolerance of myotonic distrophy. J Neurol Sci 276:60–65

Dahlqvist JR, Ørngreen MC, Witting N, Vissing J (2015) Endocrine function over time in patients with myotonic dystrophy type 1. Eur J Neurol 22:116–122

Vujnic M, Peric S, Popovic S, Raseta N, Ralic V, Dobricic V, Novakovic I, Rakocevic-Stojanovic V (2015) Metabolic syndrome in patients with Myotonic dystrophy type 1. Muscle Nerve 2(2):273–277

Kalafateli M, Triantos C, Tsamandas A, Kounadis G, Labropoulou-Karatza C (2012) Abnormal liver function tests in a patient with myotonic dystrophy type 1. Ann Hepatol 11:130–133

Achiron A, Barak Y, Magal N, Shohat M, Cohen M, Barar R, Gadoth N (1998) Abnormal liver tests results in myotonic dystrophy. J Clin Gastroenterol 26:292–295

Heatwole C, Miller J, Martens B, Moxley R (2006) Laboratoty abnormalities in ambulatory patients with myotonic dystrophy type 1. Arch Neurol 63:1149–1153

Dogan C, De Antonio M, Hamroun D, Varet H, Fabbro M, Rougier F, Amarof K et al (2016) Gender as a modifying factor influencing myotonic dystrophy type 1 phenotype severity and mortality: a nationwide multiple databases cross-sectional observational study. PLoS One 11(2):e0148264