Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol
Tóm tắt
The efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power. In addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol.
Tài liệu tham khảo
Bloomfield SS, Barden TP, Mitchell J (1977) Naproxen, aspirin, and codeine in postpartum uterine pain. Clin Pharmacol Ther 21: 414–421
Bloomfield SS, Cissell GB, Peters NM, Mitchell J, Nelson ED, Barden TP (1987) Anirolac vs. naproxen for postpartum uterine pain. Clin Pharmacol Ther 42: 89–95
Csapo AI, Pulkkinen MO, Henzl MR (1977) The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 13: 193–199
Henzl MR, Buttram V, Segre EJ, Bessler S (1977) The treatment of dysmenorrhoea with naproxen sodium. A report on two independent double-blind trials. Am J Obstet Gynecol 127: 818–823
Lawrence RA (1989) Breastfeeding - A guide for the medical profession. 3rd ed. Mosby, St. Louis
Lehmann EL (1975) Nonparametrics: Statistical methods based on ranks. Holden-Day, San Francisco
Lundström V, Green K, Wiqvist N (1976) Prostaglandins, indomethacin and dysmenorrhoea. Prostaglandins 11: 893–904
Milsom I, Andersch B (1984) Ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhea. Br J Obstet Gynaecol 91: 1129–1135
Pulkkinen MO, Csapo AI (1978) The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 15: 1055–1062
Skovlund E, Walløe L (1988) A sequential two-sample test developed by stochastic simulation. J Stat Comput Simul 29: 87–104
Skovlund E, Walløe L (1989) Estimation of treatment difference following a sequential clinical trial. JASA 84: 823–828
Skovlund E (1991) Truncation of a two sample sequential Wilcoxon test. Biometr J, 3 (in press)
Skovlund E, Fyllingen G, Landre H, Nesheim B-I (1991) Comparison of postpartum pain treatments using a sequential trial design. I. Paracetamol versus placebo. Eur J Clin Pharmacol, 40, (in press)