Effects of long-term dietary nitrate supplementation in mice

Mensinga, 2003, Health implications of exposure to environmental nitrogenous compounds, Toxicological Reviews, 22, 41, 10.2165/00139709-200322010-00005 Tannenbaum, 1985, Nitrate and gastric cancer risks, Nature, 317, 675, 10.1038/317675b0 Moncada, 1991, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacological Reviews, 43, 109 Lundberg, 2008, The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics, Nature Reviews Drug Discovery, 7, 156, 10.1038/nrd2466 Lundberg, 2004, Nitrate, bacteria and human health, Nature Reviews Microbiology, 2, 593, 10.1038/nrmicro929 Weitzberg, 2013, Novel aspects of dietary nitrate and human health, Annual Review of Nutrition, 33, 129, 10.1146/annurev-nutr-071812-161159 Larsen, 2006, Effects of dietary nitrate on blood pressure in healthy volunteers, New England Journal of Medicine, 355, 2792, 10.1056/NEJMc062800 Webb, 2008, Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite, Hypertension, 51, 784, 10.1161/HYPERTENSIONAHA.107.103523 Richardson, 2002, The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans, Nitric Oxide, 7, 24, 10.1016/S1089-8603(02)00010-1 Rodriguez-Mateos, 2015, Interactions between cocoa flavanols and inorganic nitrate: additive effects on endothelial function at achievable dietary amounts, Free Radical Biology and Medicine, 80, 121, 10.1016/j.freeradbiomed.2014.12.009 Larsen, 2011, Dietary inorganic nitrate improves mitochondrial efficiency in humans, Cell Metabolism, 13, 149, 10.1016/j.cmet.2011.01.004 Govoni, 2008, The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash, Nitric Oxide, 19, 333, 10.1016/j.niox.2008.08.003 Kapil, 2013, Physiological role for nitrate-reducing oral bacteria in blood pressure control, Free Radical Biology and Medicine, 55, 93, 10.1016/j.freeradbiomed.2012.11.013 Petersson, 2009, Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash, Free Radical Biology and Medicine, 46, 1068, 10.1016/j.freeradbiomed.2009.01.011 Bazzano, 2008, Intake of fruit, vegetables, and fruit juices and risk of diabetes in women, Diabetes Care, 31, 1311, 10.2337/dc08-0080 Park, 2009, Fruit, vegetable, and fish consumption and heart rate variability: the veterans administration normative aging study, American Journal of Clinical Nutrition, 89, 778, 10.3945/ajcn.2008.26849 Aly, 2010, Potential testicular toxicity of sodium nitrate in adult rats, Food and Chemical Toxicology, 48, 572, 10.1016/j.fct.2009.11.034 Chow, 1980, Effect of nitrate and nitrite in drinking water on rats, Toxicology Letters, 6, 199, 10.1016/0378-4274(80)90192-7 Chow, 2002, Dietary vitamin E and selenium and toxicity of nitrite and nitrate, Toxicology, 180, 195, 10.1016/S0300-483X(02)00391-8 El-Wakf, 2015, Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats, Cytotechnology, 67, 437, 10.1007/s10616-014-9702-7 Maekawa, 1982, Carcinogenicity studies of sodium nitrite and sodium nitrate in F−344 rats, Food and Chemical Toxicology, 20, 25, 10.1016/S0278-6915(82)80005-7 Yang, 2015, Abrogation of adenosine A receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses, Diabetologia, 10.1007/s00125-015-3570-3 Gao, 2015, NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite, Hypertension, 65, 161, 10.1161/HYPERTENSIONAHA.114.04222 Mulvany, 1977, Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats, Circulation Research, 41, 19, 10.1161/01.RES.41.1.19 Brown, 2011, Simultaneous determination of 6 L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray tandem mass spectrometry, Clinical Chemistry, 57, 701, 10.1373/clinchem.2010.155895 Chaoui, 2004, Effects of inorganic nitrates on thyroid gland activity and morphology in female rats, Therapie, 59, 471, 10.2515/therapie:2004079 Jahreis, 1991, Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats, Experimental and Clinical Endocrinology, 97, 109, 10.1055/s-0029-1211049 Oğur, 2000, Effects of high nitrate intake in rats, Journal of Basic and Clinical Physiology and Pharmacology, 11, 47, 10.1515/JBCPP.2000.11.1.47 Carlström, 2010, Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice, Proceedings of the National Acadamy of Science United States of America, 107, 17716, 10.1073/pnas.1008872107 Jahreis, 1987, Growth impairment caused by dietary nitrate intake regulated via hypothyroidism and decreased somatomedin, Endocrinologia Experimentalis, 21, 171 Larsen, 2014, Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans, American Journal of Clinical Nutrition, 99, 843, 10.3945/ajcn.113.079491 Larsen, 2007, Effects of dietary nitrate on oxygen cost during exercise, Acta Physiologica (Oxford), 191, 59, 10.1111/j.1748-1716.2007.01713.x Carlström, 2014, Cross-talk between nitrate–Nitrite-NO and NO synthase pathways in control of vascular NO homeostasis, Antioxidants and Redox Signaling Franceschi, 2014, Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases, Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69, S4, 10.1093/gerona/glu057 WHO, Nitrate and Nitrite in Drinking Water, Background Document for Guidelines for Drinking Water Quality [PDF] 20112011, Available from: 〈http://www.who.int/water_sanitation_health/dwq/chemicals/nitratesnitrite/en/〉 (cited 19.04.15). van Vliet, 1997, Twenty-four-hour duplicate diet study 1994; nitrate and nitrite: method development and intake per person per day, Cancer Letters, 114, 305, 10.1016/S0304-3835(97)04688-0 Boelen, 1996, Relationship between serum 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness, Journal of Endocrinological Investigation, 19, 480, 10.1007/BF03349894 Abo-Zenah, 2008, Relating circulating thyroid hormone concentrations to serum interleukins-6 and −10 in association with non-thyroidal illnesses including chronic renal insufficiency, B.M.C. Endocrine Disorders, 8, 1, 10.1186/1472-6823-8-1 Iglesias, 2003, Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function, Clinical Endocrinology (Oxford), 59, 621, 10.1046/j.1365-2265.2003.01897.x Li, 2014, Clinical evaluation of various thyroid hormones on thyroid function, International Journal of Endocrinology, 2014, 618572, 10.1155/2014/618572 Agnihothri, 2014, Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion, Thyroidology, 24, 19, 10.1089/thy.2013.0055 Astrup, 1996, Low resting metabolic rate in subjects predisposed to obesity: a role for thyroid status, American Journal of Clinical Nutrition, 63, 879, 10.1093/ajcn/63.6.879 Pourhassan, 2014, Impact of body composition during weight change on resting energy expenditure and homeostasis model assessment index in overweight nonsmoking adults, American Journal of Clinical Nutrition, 99, 779, 10.3945/ajcn.113.071829 Jahreis, 1986, Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C-level and growth, Experimental and Clinical Endocrinology, 88, 242 Mukhopadhyay, 2005, Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant, Indian Journal of Physiology and Pharmacology, 49, 284 Zaki, 2004, Impact of nitrate intake in drinking water on the thyroid gland activity in male rat, Toxicology Letters, 147, 27, 10.1016/j.toxlet.2003.10.010 Aroor, 2013, Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance, Metabolism, 62, 1543, 10.1016/j.metabol.2013.07.001 Kedzierski, 2008, Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites, European Journal of Immunology, 38, 3090, 10.1002/eji.200838423 Petursdottir, 2002, Dietary fish oil increases tumor necrosis factor secretion but decreases interleukin-10 secretion by murine peritoneal macrophages, Journal of Nutrition, 132, 3740, 10.1093/jn/132.12.3740 Hirotani, 2010, Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis, Journal of Neuroimmunology, 221, 95, 10.1016/j.jneuroim.2010.02.012 Jädert, 2012, Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury, Free Radical Biology and Medicine, 52, 683, 10.1016/j.freeradbiomed.2011.11.018 Yang, 2015, Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism, Free Radical Biology and Medicine, 83, 159, 10.1016/j.freeradbiomed.2015.02.016