Gambling on putative biomarkers of osteoarthritis and osteochondrosis by equine synovial fluid proteomics

Jeffcott, 1991, Osteochondrosis in the horse–Searching for the key to pathogenesis, Equine Vet J, 23, 331, 10.1111/j.2042-3306.1991.tb03733.x Ferris, 2011, Current joint therapy usage in equine practice: A survey of veterinarians 2009, Equine Vet J, 43, 530, 10.1111/j.2042-3306.2010.00324.x Ross, 2010 McIlwraith, 1996 van Weeren, 2006, Etiology, diagnosis, and treatment of OC(D), Clin Tech Equine Pract, 5, 248, 10.1053/j.ctep.2006.08.002 Ekman, 1998, The pathophysiology of osteochondrosis, Vet Clin North Am Small Anim Pract, 28, 17, 10.1016/S0195-5616(98)50002-2 Jeffcott, 1998, Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (osteochondrosis), Vet J, 156, 177, 10.1016/S1090-0233(98)80121-4 Ytrehus, 2007, Etiology and Pathogenesis of Osteochondrosis, Vet Pathol, 44, 429, 10.1354/vp.44-4-429 Lecocq, 2008, Cartilage matrix changes in the developing epiphysis: Early events on the pathway to equine osteochondrosis?, Equine Vet J, 40, 442, 10.2746/042516408X297453 Frisbie, 1999, Measurement of synovial fluid and serum concentration of the 846 epitope of chondroitin sulfate and carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses, Am J Vet Res, 60, 306 Serteyn, 2010, Gene expression profiling from leukocytes of horses affected by osteochondrosis, J Orthop Res, 28, 965, 10.1002/jor.21089 Olive, 2010, Fat-suppressed spoiled gradient-recalled imaging of equine metacarpophalangeal articular cartilage, Vet Radiol Ultrasound, 51, 107 Hinz, 2011, Comparison of the accuracy of radiography and ultrasonography for detection of articular lesions in horses, Vet Surg, 40, 881 McIlwraith, 2005, Use of synovial fluid and serum biomarkers in equine bone and joint disease: a review, Equine Vet J, 37, 473, 10.2746/042516405774480102 de Grauw, 2009, Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study, Arthritis Res Ther, 11, R35, 10.1186/ar2640 Garvican, 2010, Biomarkers of cartilage turnover. Part 1: markers of collagen degradation and synthesis, Vet J, 185, 36, 10.1016/j.tvjl.2010.04.011 de Grauw, 2011, Assessment of synovial fluid biomarkers in healthy foals and in foals with tarsocrural osteochondrosis, Vet J, 190, 390, 10.1016/j.tvjl.2010.12.001 Sutton, 2009, The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis, Vet J, 179, 10, 10.1016/j.tvjl.2007.08.013 Misumi, 2001, Measurement of cartilage oligomeric matrix protein (COMP) in normal and diseased equine synovial fluids, Osteoarthritis Cartilage, 9, 119, 10.1053/joca.2000.0367 Arai, 2005, Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease, Equine Vet J, 37, 31, 10.2746/0425164054406784 Taylor, 2006, Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population, Equine Vet J, 38, 502, 10.2746/042516406X156073 Ley, 2007, Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology, J Vet Med A Physiol Pathol Clin Med, 54, 346, 10.1111/j.1439-0442.2007.00956.x Arai, 2008, Analysis of cartilage oligomeric matrix protein (COMP) in synovial fluid, serum and urine from 51 racehorses with carpal bone fracture, J Vet Med Sci, 70, 915, 10.1292/jvms.70.915 Frisbie, 2008, Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses, Osteoarthritis Cartilage, 16, 1196, 10.1016/j.joca.2008.03.008 Yamanokuchi, 2009, Sandwich ELISA system for cartilage oligomeric matrix protein in equine synovial fluid and serum, Equine Vet J, 4, 41, 10.2746/042516408X330356 Kamm, 2010, Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi, Equine Vet J, 42, 693, 10.1111/j.2042-3306.2010.00140.x Skiöldebrand, 2001, Concentration of collagen, aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid from equine middle carpal joints, Equine Vet J, 33, 394, 10.2746/042516401776249480 Billinghurst, 2004, Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals, Am J Vet Res, 65, 143, 10.2460/ajvr.2004.65.143 Donabédian, 2008, Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse, Equine Vet J, 40, 253, 10.2746/042516408X273657 Tilleman, 2005, Rheumatology: a close encounter with proteomics, Rheumatology, 44, 1217, 10.1093/rheumatology/keh694 De Ceuninck, 2007, The birth and infancy of proteomic analysis in osteoarthritis research, Curr Opin Mol Ther, 9, 263 Kamphorst, 2007, Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification, J Proteome Res, 6, 4388, 10.1021/pr0704534 Tilleman, 2008, Proteomics in rheumatology, Expert Rev Proteomics, 5, 755, 10.1586/14789450.5.6.755 Camafeita, 2009, Proteomics: New insights into rheumatic diseases, Proteomics Clin Appl, 3, 226, 10.1002/prca.200800146 Cano, 2009, Targeted Synovial Fluid Proteomics for Biomarker Discovery in Rheumatoid Arthritis, Clin Proteomics, 5, 75, 10.1007/s12014-009-9028-1 Rosenkranz, 2010, Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis, Arthritis Rheum, 62, 1813, 10.1002/art.27447 Mateos, 2012, Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF/TOF, J Proteomics, 8 Gobezie, 2007, High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis, Arthritis Res Ther, 9, R36, 10.1186/ar2172 Gibson, 2009, Stratification and monitoring of juvenile idiopathic arthritis patients by synovial proteome analysis, J Proteome Res, 8, 5601, 10.1021/pr900680w Gibson, 2009, Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease, J Proteomics, 7, 656, 10.1016/j.jprot.2009.01.022 Blewis, 2007, A model of synovial fluid lubricant composition in normal and injured joints, Eur Cell Mater, 13, 26, 10.22203/eCM.v013a03 Steel, 2008, Equine synovial fluid analysis, Vet Clin North Am Equine Pract, 24, 437, 10.1016/j.cveq.2008.05.004 Catterall, 2010, Changes in serum and synovial fluid biomarkers after acute injury, Arthritis Res Ther, 12, R229, 10.1186/ar3216 Kokebie, 2011, The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors, Arthritis Res Ther, 13, R50, 10.1186/ar3293 Honsawek, 2010, Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity, Arch Med Res, 41, 593, 10.1016/j.arcmed.2010.11.007 Frisbie, 2007, Clinical, biochemical, and histologic effects of intraarticular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis, Am J Vet Res, 68, 290, 10.2460/ajvr.68.3.290 Fox, 2010, Treatment of knee osteoarthritis with Orthokine®-derived autologous conditioned serum, Expert Rev Clin Immunol, 6, 335, 10.1586/eci.10.17 Hraha, 2011, Autologous conditioned serum: the comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood, Equine Vet J, 43, 516, 10.1111/j.2042-3306.2010.00321.x Malemud, 2010, Anticytokine therapy for osteoarthritis: evidence to date, Drugs Aging, 27, 95, 10.2165/11319950-000000000-00000 Meijer, 2003, The production of anti-inflammatory cytokines in whole blood by physico-chemical induction, Inflamm Res, 52, 404, 10.1007/s00011-003-1197-1 Wehling, 2007, Autologous Conditioned Serum in the Treatment of Orthopedic Diseases: The Orthokine® Therapy, BioDrugs, 21, 323, 10.2165/00063030-200721050-00004 Aigner, 2010, Histopathology atlas of animal model systems - overview of guiding principles, Osteoarthritis Cartilage, 18, S2, 10.1016/j.joca.2010.07.013 Talamo, 2003, Proteins from bovine tissues and biological fluids: defining a reference electrophoresis map for liver, kidney, muscle, plasma and red blood cells, Proteomics, 3, 440, 10.1002/pmic.200390059 Scippa, 2010, The proteome of lentil (Lens culinaris Medik.) seeds: discriminating between landraces, Electrophoresis, 31, 497, 10.1002/elps.200900459 Perkins, 1999, Probability-based protein identification by searching sequence databases using mass spectrometry data, Electrophoresis, 20, 3551, 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 Lin, 2010, The role of ADAMTSs in arthritis, Protein Cell, 33, 10.1007/s13238-010-0002-5 Cáceres, 2010, Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines, J Cell Biochem, 15, 607, 10.1002/jcb.22737 Wu, 2001, α2-Macroglobulin from Rheumatoid Arthritis Synovial Fluid: Functional Analysis Defines a Role for Oxidation in Inflammation, Arch Biochem Biophys, 391, 119, 10.1006/abbi.2001.2408 Hultén, 2002, Dynamics in serum of the inflammatory markers serum amyloid A (SAA), haptoglobin, fibrinogen and alpha2-globulins during induced noninfectious arthritis in the horse, Equine Vet J, 34, 699, 10.2746/042516402776250405 Pejovic, 1995, Determination of the apparent synovial permeability in the knee joint of patients suffering from osteoarthritis and rheumatoid arthritis, Br J Rheumatol, 34, 520, 10.1093/rheumatology/34.6.520 Lauer, 2009, Airway Smooth Muscle Cells Synthesize Hyaluronan Cable Structures Independent of Inter-a-inhibitor Heavy Chain Attachment, J Biol Chem, 284, 5313, 10.1074/jbc.M807979200 Trumble, 2001, Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses, Am J Vet Res, 62, 1467, 10.2460/ajvr.2001.62.1467 Kuroki, 2005, Characterizing osteochondrosis in the dog: potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression, Osteoarthritis Cartilage, 13, 225, 10.1016/j.joca.2004.11.005 Ryan, 2008, Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid, Mol Immunol, 45, 1837, 10.1016/j.molimm.2007.10.043 Kratz, 2010, Terminal monosaccharide screening of synovial immunoglobulins G and A for the early detection of rheumatoid arthritis, Rheumatol Int, 30, 1285, 10.1007/s00296-009-1139-5 John, 2007, Impact of the complement cascade on posttraumatic cartilage inflammation and degradation, Histol Histopathol, 22, 781 Sofat, 2009, Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Review, Int J Exp Pathol, 90, 463, 10.1111/j.1365-2613.2009.00676.x Choi, 2006, The relationship between inflammation and the coagulation system, Swiss Med Wkly, 4, 139 Bradley, 1996, Synthesis of classical pathway complement components by chondrocytes, Immunology, 88, 648 Neumann, 2002, Local production of complement proteins in rheumatoid arthritis synovium, Arthritis Rheum, 46, 934, 10.1002/art.10183 Rosenthal, 2011, Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage, Arthritis Rheum, 63, 401, 10.1002/art.30120 Happonen, 2010, Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis, Arthritis Rheum, 62, 3574, 10.1002/art.27720 Andrades, 1996, Complement proteins are present in developing endochondral bone and may mediate cartilage cell death and vascularization, Exp Cell Res, 15, 208, 10.1006/excr.1996.0269 Jones, 1998, Inactivation of antithrombin III in synovial fluid from patients with rheumatoid arthritis, Ann Rheum Dis, 57, 162, 10.1136/ard.57.3.162 Chang, 2005, Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis, Arthritis Res Ther, 7, 268, 10.1186/ar1487 Flick, 2007, Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif, J Clin Invest, 117, 3224, 10.1172/JCI30134 Craven, 2007, Altered regulation of in-vivo coagulation in orthopedic patients prior to knee or hip replacement surgery, Blood Coagul Fibrinolysis, 18, 219, 10.1097/01.mbc.0000264704.90039.5d Ashraf, 2008, Angiogenesis in osteoarthritis, Curr Opin Rheumatol, 20, 573, 10.1097/BOR.0b013e3283103d12 Busso, 2001, Plasma apolipoprotein(a) co-deposits with fibrin in inflammatory arthritic joints, Am J Pathol, 159, 1445, 10.1016/S0002-9440(10)62531-X Sánchez-Enríquez, 2008, Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms, Rheumatol Int, 29, 63, 10.1007/s00296-008-0633-5 Oliviero, 2009, Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis, Clin Exp Rheumatol, 27, 79 Masuko, 2009, A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation, Clin Exp Rheumatol, 27, 347 Vieth, 2007, Toxicity, policy, and science, J Bone Miner Res, 22, S264, 10.1359/jbmr.07s221 Satoh, 2006, Structure, function and regulation of carboxylesterases, Chem Biol Interact, 162, 195, 10.1016/j.cbi.2006.07.001 Jerkovic, 2005, Afamin is a novel human vitamin e-binding glycoprotein characterization and in vitro expression, J Proteome Res, 4, 889, 10.1021/pr0500105 Henrotin, 2003, The role of reactive oxygen species in homeostasis and degradation of cartilage, Osteoarthritis Cartilage, 11, 747, 10.1016/S1063-4584(03)00150-X Yazar, 2005, Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis, Biol Trace Elem Res, 106, 123, 10.1385/BTER:106:2:123 Regan, 2008, Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury, Osteoarthritis Cartilage, 16, 515, 10.1016/j.joca.2007.09.001 Sutipornpalangkul, 2009, Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis, Int J Rheum Dis, 12, 324, 10.1111/j.1756-185X.2009.01430.x Kagan, 2003, Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell, J Cell Biochem, 8, 660, 10.1002/jcb.10413 Badadani, 2007, Metabolic status of magnesium and ceruloplasmin in Handigodu Joint Disease: a variety of spondylo epi (meta) physeal dysplasia, Clin Chim Acta, 395, 170, 10.1016/j.cca.2008.05.017 van Weeren, 2003, Influence of liver copper status of mare and newborn foal on the development of osteochondrotic lesions, Equine Vet J, 35, 67, 10.2746/042516403775467469 Kisker, 2003, Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and fumor growth in mice, Neoplasia, 5, 32, 10.1016/S1476-5586(03)80015-5 Schneider, 2003, The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone, Crit Rev Eukaryot Gene Expr, 13, 277, 10.1615/CritRevEukaryotGeneExpr.v13.i24.190 Lee, 1992, The extracellular actin-scavenger system and actin toxicity, N Engl J Med, 326, 1335, 10.1056/NEJM199205143262006 Blain, 2009, Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology, Int J Exp Pathol, 90, 1, 10.1111/j.1365-2613.2008.00625.x