Relation of Body Mass Index to High On-Treatment Platelet Reactivity and of Failed Clopidogrel Dose Adjustment According to Platelet Reactivity Monitoring in Patients Undergoing Percutaneous Coronary Intervention

American Journal of Cardiology - Tập 104 - Trang 1511-1515 - 2009
Nathalie Bonello-Palot1, Sébastien Armero2, Franck Paganelli2, Julien Mancini3,4, Axel De Labriolle5, Caroline Bonello6, Nicolas Lévy1, Luc Maillard7, Paul Barragan8, Françoise Dignat-George9,10, Laurence Camoin-Jau9,10, Laurent Bonello2,9
1Département de génétique médicale, Hôpital de la Timone enfant, Marseille, France
2Département de Cardiologie, Hôpital Universitaire Nord, Marseille, France
3Assistance Publique, Hôpitaux de Marseille, Hôpital de la Timone, SSPIM, Marseille, France
4Faculté de Médecine de Marseille, Aix-Marseille Université, LERTIM (EA 3283), Marseille, France
5Service des Soins Intensifs, Département de Cardiologie, Hôpital de Tours, Tours, France
6Service de Santé Publique et Information Médicale, Faculté de Médecine, Hôpital Universitaire Nord, Marseille, France
7Service de Cardiologie, Clinique Axium, Aix-en-Provence, France
8Service de Cardiologie, Clinique les Fleurs, Ollioules, France
9Faculté de Pharmacie, INSERM UMRS 608, Marseille, France
10Laboratoire d'hématologie, Hôpital de la Conception, Marseille, France

Tài liệu tham khảo

Schwarz, 1999, Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets—definition and detection of ticlopidine/clopidogrel effects, Thromb Haemost, 82, 1145, 10.1055/s-0037-1614344 Barragan, 2003, Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator 6 stimulated phosphoprotein phosphorylation, Catheter Cardiovasc Interv, 59, 295, 10.1002/ccd.10497 Bonello, 2007, Vasodilator-stimulated phosphoprotein phosphorylation analysis prior to percutaneous coronary intervention for exclusion of postprocedural major adverse cardiovascular events, J Thromb Haemost, 5, 1630, 10.1111/j.1538-7836.2007.02609.x Frere, 2007, ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome, Thromb Haemost, 98, 838, 10.1160/TH07-04-0296 Blindt, 2007, The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis, Thromb Haemost, 98, 1329, 10.1160/TH07-05-0324 Bonello, 2008, Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study, J Am Coll Cardiol, 51, 1404, 10.1016/j.jacc.2007.12.044 Bonello, 2009, Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis, Am J Cardiol, 103, 5, 10.1016/j.amjcard.2008.08.048 Fontana, 2007, Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects, J Thromb Haemost, 5, 2153, 10.1111/j.1538-7836.2007.02722.x Mega, 2009, Cytochrome p-450 polymorphisms and response to clopidogrel, N Engl J Med, 360, 354, 10.1056/NEJMoa0809171 Angiolillo, 2005, Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment, Diabetes, 54, 2430, 10.2337/diabetes.54.8.2430 Ferroni, 2004, Platelet activation in type 2 diabetes mellitus, J Thromb Haemost, 2, 1282, 10.1111/j.1538-7836.2004.00836.x Erlinge, 2008, Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo, J Am Coll Cardiol, 52, 1968, 10.1016/j.jacc.2008.07.068 Geisler, 2008, Residual platelet activity is increased in clopidogrel- and ASA-treated patients with coronary stenting for acute coronary syndromes compared with stable coronary artery disease, Heart, 94, 743, 10.1136/hrt.2006.100891 Soffer, 2003, Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?, Catheter Cardiovasc Interv, 59, 21, 10.1002/ccd.10494 2009, Genetic determinants of response to clopidogrel and cardiovascular events, N Engl J Med, 360, 363, 10.1056/NEJMoa0808227 Collet, 2009, Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study, Lancet, 373, 309, 10.1016/S0140-6736(08)61845-0 Angiolillo, 2004, Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose Be weight adjusted?, J Invasive Cardiol, 16, 169 Cuisset, 2009, Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response, Thromb Res, 123, 597, 10.1016/j.thromres.2008.04.003 Scherrer, 1991, Effect of weight reduction in moderately overweight patients on recorded ambulatory blood pressure and free cytosolic platelet calcium, Circulation, 83, 552, 10.1161/01.CIR.83.2.552 Kotlyar, 1999, Effects of obesity on the cytochromes P450 enzyme system, Int J Pharmacol Ther, 37, 8