Hypoxia-inducible factor pathway and diseases of the vascular wall
Tài liệu tham khảo
Kasivisvanathan, 2011, Hypoxia-inducible factor-1 in arterial disease: a putative therapeutic target, Curr Vasc Pharmacol, 9, 333, 10.2174/157016111795495602
Eberhardt, 2005, Chronic venous insufficiency, Circulation, 111, 2398, 10.1161/01.CIR.0000164199.72440.08
Lim, 2010, Venous hypoxia: a poorly studied etiological factor of varicose veins, J Vasc Res, 48, 185, 10.1159/000320624
Sluimer, 2009, Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis, J Pathol, 218, 7, 10.1002/path.2518
Semenza, 2012, Hypoxia-inducible factors in physiology and medicine, Cell, 148, 399, 10.1016/j.cell.2012.01.021
Wiesener, 2003, Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs, FASEB J, 17, 271, 10.1096/fj.02-0445fje
Talks, 2000, Harris The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages, Am J Pathol, 157, 411, 10.1016/S0002-9440(10)64554-3
Semenza, 2009, Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis, Blood, 114, 2015, 10.1182/blood-2009-05-189985
Semenza, 2009, Regulation of oxygen homeostasis by hypoxia-inducible factor 1, Physiology (Bethesda), 24, 97, 10.1152/physiol.00045.2008
Muz, 2009, Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis, Arthritis Res Ther, 11, 201, 10.1186/ar2568
Konisti, 2012, Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis, Nat Rev Rheumatol, 8, 153, 10.1038/nrrheum.2011.205
Kaelin, 2008, Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway, Mol Cell, 30, 393, 10.1016/j.molcel.2008.04.009
Mahon, 2001, FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity, Genes Dev, 15, 2675, 10.1101/gad.924501
Patiar, 2006, Role of hypoxia-inducible factor-1alpha as a cancer therapy target, Endocr Relat Cancer, 13, S61, 10.1677/erc.1.01290
Semenza, 2010, Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics, Oncogene, 29, 625, 10.1038/onc.2009.441
Lando, 2002, Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch, Science, 295, 858, 10.1126/science.1068592
Ziello, 2007, Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia, Yale J Biol Med, 80, 51
Shackleford, 2010, JAB1/CSN5: a new player in cell cycle control and cancer, Cell Div, 5, 26, 10.1186/1747-1028-5-26
Bitto, 2010, Evidence for markers of hypoxia and apoptosis in explanted human carotid atherosclerotic plaques, J Vasc Surg, 52, 1015, 10.1016/j.jvs.2010.05.116
Sluimer, 2008, Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis, J Am Coll Cardiol, 51, 1258, 10.1016/j.jacc.2007.12.025
Zemplenyi, 1989, Adaptation to arterial wall hypoxia demonstrated in vivo with oxygen microcathodes, Atherosclerosis, 76, 173, 10.1016/0021-9150(89)90101-9
Jurrus, 1977, In vitro tissue oxygen tensions in the rabbit aortic arch, Atherosclerosis, 28, 223, 10.1016/0021-9150(77)90172-1
Cramer, 2003, HIF-1alpha is essential for myeloid cell-mediated inflammation, Cell, 112, 645, 10.1016/S0092-8674(03)00154-5
Murdoch, 2005, Hypoxia regulates macrophage functions in inflammation, J Immunol, 175, 6257, 10.4049/jimmunol.175.10.6257
Burke, 2003, Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy, Am J Pathol, 163, 1233, 10.1016/S0002-9440(10)63483-9
Lobanova, 2006, Hydrogen peroxide metabolism in alveolar macrophages after exposure to hypoxia and heat, Physiol Res, 55, 569, 10.33549/physiolres.930863
Lattimore, 2005, Repetitive hypoxia increases lipid loading in human macrophages-a potentially atherogenic effect, Atherosclerosis, 179, 255, 10.1016/j.atherosclerosis.2004.11.010
Rydberg, 2004, Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages, Arterioscler Thromb Vasc Biol, 24, 2040, 10.1161/01.ATV.0000144951.08072.0b
Bostrom, 2006, Hypoxia converts human macrophages into triglyceride-loaded foam cells, Arterioscler Thromb Vasc Biol, 26, 1871, 10.1161/01.ATV.0000229665.78997.0b
Nakano, 2005, Chronic hypoxia accelerates the progression of atherosclerosis in apolipoprotein E-knockout mice, Hypertens Res, 28, 837, 10.1291/hypres.28.837
Savransky, 2007, Chronic intermittent hypoxia induces atherosclerosis, Am J Respir Crit Care Med, 175, 1290, 10.1164/rccm.200612-1771OC
Chen, 2005, Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque, Coron Artery Dis, 16, 191, 10.1097/00019501-200505000-00009
Luque, 2008, Overexpression of hypoxia/inflammatory markers in atherosclerotic carotid plaques, Front Biosci, 13, 6483, 10.2741/3168
Vink, 2007, HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages, Atherosclerosis, 195, e69, 10.1016/j.atherosclerosis.2007.05.026
Higashida, 2008, Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and E26 transformation-specific-1) and plaque hemorrhage in human carotid atherosclerosis, J Neurosurg, 109, 83, 10.3171/JNS/2008/109/7/0083
Fu, 2010, Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway, BMC Cell Biol, 11, 66, 10.1186/1471-2121-11-66
Li, 2012, Overexpression of ETS-1 is associated with malignant biological features of prostate cancer, Asian J Androl, 14, 860, 10.1038/aja.2012.107
Jiang, 2007, RNA interference for HIF-1alpha inhibits foam cells formation in vitro, Eur J Pharmacol, 562, 183, 10.1016/j.ejphar.2007.01.066
Na, 2011, Positive cross-talk between hypoxia inducible factor-1alpha and liver X receptor alpha induces formation of triglyceride-loaded foam cells, Arterioscler Thromb Vasc Biol, 31, 2949, 10.1161/ATVBAHA.111.235788
Parathath, 2011, Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism, Circ Res, 109, 1141, 10.1161/CIRCRESAHA.111.246363
Drager, 2010, Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis, Curr Opin Endocrinol Diabetes Obes, 17, 161, 10.1097/MED.0b013e3283373624
Asplund, 2010, Hypoxic regulation of secreted proteoglycans in macrophages, Glycobiology, 20, 33, 10.1093/glycob/cwp139
Asplund, 2011, Macrophages exposed to hypoxia secrete proteoglycans for which LDL has higher affinity, Atherosclerosis, 215, 77, 10.1016/j.atherosclerosis.2010.12.017
Castellano, 2011, Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1alpha in human vascular smooth muscle cells, Arterioscler Thromb Vasc Biol, 31, 1411, 10.1161/ATVBAHA.111.225490
Choke, 2006, Hypoxia at the site of abdominal aortic aneurysm rupture is not associated with increased lactate, Ann N Y Acad Sci, 1085, 306, 10.1196/annals.1383.005
Vorp, 2001, Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening, J Vasc Surg, 34, 291, 10.1067/mva.2001.114813
Vorp, 1998, Effect of intraluminal thrombus thickness and bulge diameter on the oxygen diffusion in abdominal aortic aneurysm, J Biomech Eng, 120, 579, 10.1115/1.2834747
Coutard, 2010, Thrombus versus wall biological activities in experimental aortic aneurysms, J Vasc Res, 47, 355, 10.1159/000265569
Vorp, 1996, Does laminated intraluminal thrombus within abdominal aortic aneurysm cause anoxia of the aortic wall?, J Vasc Surg, 23, 540, 10.1016/S0741-5214(96)80027-9
Vorp, 1996, Potential influence of intraluminal thrombus on abdominal aortic aneurysm as assessed by a new non-invasive method, Cardiovasc Surg, 4, 732, 10.1016/S0967-2109(96)00008-7
Freestone, 1995, Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm, Arterioscler Thromb Vasc Biol, 15, 1145, 10.1161/01.ATV.15.8.1145
Hu, 2004, Zhonghua Wai Ke Za Zhi, 42, 1509
Erdozain, 2011, Hypoxia in abdominal aortic aneurysm supports a role for HIF-1alpha and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells, J Vasc Res, 48, 163, 10.1159/000318806
Van Vickle-Chavez, 2006, Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms, J Vasc Surg, 43, 1010, 10.1016/j.jvs.2006.01.004
Sakata, 2007, Possible involvement of myofibroblast in the development of inflammatory aortic aneurysm, Pathol Res Pract, 203, 21, 10.1016/j.prp.2006.08.008
Kurki, 2011, Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-kappaB, hypoxia-inducible factor-1A, and ETS transcription factors, Neurosurgery, 68, 1667, 10.1227/NEU.0b013e318210f001
Rizzo, 2009, LDL size and subclasses in patients with abdominal aortic aneurysm, Int J Cardiol, 134, 406, 10.1016/j.ijcard.2007.12.082
Shimoda, 2011, HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease, Am J Respir Crit Care Med, 183, 152, 10.1164/rccm.201009-1393PP
Stenmark, 2006, Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms, Circ Res, 99, 675, 10.1161/01.RES.0000243584.45145.3f
Jeffery, 2001, Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension, Pharmacol Ther, 92, 1, 10.1016/S0163-7258(01)00157-7
Theo Schermuly, 2005, Prostanoids and phosphodiesterase inhibitors in experimental pulmonary hypertension, Curr Top Dev Biol, 67, 251, 10.1016/S0070-2153(05)67008-1
Hanze, 2007, Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling, Thromb Haemost, 97, 774, 10.1160/TH06-12-0744
Brusselmans, 2003, Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia, J Clin Invest, 111, 1519, 10.1172/JCI15496
Shimoda, 2001, Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia, Am J Physiol Lung Cell Mol Physiol, 281, L202, 10.1152/ajplung.2001.281.1.L202
Yu, 1999, Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha, J Clin Invest, 103, 691, 10.1172/JCI5912
Whitman, 2008, Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes, Am J Physiol Lung Cell Mol Physiol, 294, L309, 10.1152/ajplung.00091.2007
Wang, 2006, Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells, Circ Res, 98, 1528, 10.1161/01.RES.0000227551.68124.98
Shimoda, 2006, HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes, Am J Physiol Lung Cell Mol Physiol, 291, L941, 10.1152/ajplung.00528.2005
Raghavan, 2012, Hypoxia-induced pulmonary arterial smooth muscle cell proliferation is controlled by forkhead box m1, Am J Respir Cell Mol Biol, 46, 431, 10.1165/rcmb.2011-0128OC
Krotova, 2010, Hypoxic upregulation of arginase II in human lung endothelial cells, Am J Physiol Cell Physiol, 299, C1541, 10.1152/ajpcell.00068.2010
Xu, 2004, Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension, FASEB J, 18, 1746, 10.1096/fj.04-2317fje
Tuder, 2001, Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis, J Pathol, 195, 367, 10.1002/path.953
Bonnet, 2006, An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension, Circulation, 113, 2630, 10.1161/CIRCULATIONAHA.105.609008
Bowers, 2004, Oxidative stress in severe pulmonary hypertension, Am J Respir Crit Care Med, 169, 764, 10.1164/rccm.200301-147OC
Archer, 2010, Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target, Circulation, 121, 2661, 10.1161/CIRCULATIONAHA.109.916098
Huang, 1996, Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit, J Biol Chem, 271, 32253, 10.1074/jbc.271.50.32253
Kim, 2011, Epigenetic mechanisms of pulmonary hypertension, Pulm Circ, 1, 347, 10.4103/2045-8932.87300
Sullivan, 1993, Hemodynamics of failing dialysis grafts, Radiology, 186, 867, 10.1148/radiology.186.3.8430200
Rekhter, 1993, Cell proliferation in human arteriovenous fistulas used for hemodialysis, Arterioscler Thromb, 13, 609, 10.1161/01.ATV.13.4.609
Loftus, 1999, MMP inhibition reduces intimal hyperplasia in a human vein graft stenosis model, Ann N Y Acad Sci, 878, 547, 10.1111/j.1749-6632.1999.tb07723.x
Lee, 2005, Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors, J Cell Biol, 169, 681, 10.1083/jcb.200409115
Nakao, 2011, Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts, Cardiovasc Res, 89, 457, 10.1093/cvr/cvq298
Misra, 2005, Adventitial remodeling with increased matrix metalloproteinase-2 activity in a porcine arteriovenous polytetrafluoroethylene grafts, Kidney Int, 68, 2890, 10.1111/j.1523-1755.2005.00763.x
Li, 2007, Cellular and morphological changes during neointimal hyperplasia development in a porcine arteriovenous graft model, Nephrol Dial Transplant, 22, 3139, 10.1093/ndt/gfm415
Misra, 2008, Increased expression of hypoxia-inducible factor-1 alpha in venous stenosis of arteriovenous polytetrafluoroethylene grafts in a chronic renal insufficiency porcine model, J Vasc Interv Radiol, 19, 260, 10.1016/j.jvir.2007.10.029
Misra, 2010, Hypoxia-induced phenotypic switch of fibroblasts to myofibroblasts through a matrix metalloproteinase 2/tissue inhibitor of metalloproteinase-mediated pathway: implications for venous neointimal hyperplasia in hemodialysis access, J Vasc Interv Radiol, 21, 896, 10.1016/j.jvir.2010.02.030
Misra, 2008, Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas, J Vasc Interv Radiol, 19, 252, 10.1016/j.jvir.2007.10.031
Fillinger, 1989, Beneficial effects of banding on venous intimal-medial hyperplasia in arteriovenous loop grafts, Am J Surg, 158, 87, 10.1016/0002-9610(89)90353-X
Fillinger, 1990, Graft geometry and venous intimal-medial hyperplasia in arteriovenous loop grafts, J Vasc Surg, 11, 556, 10.1016/0741-5214(90)90302-Q
Haruguchi, 2003, Intimal hyperplasia and hemodynamic factors in arterial bypass and arteriovenous grafts: a review, J Artif Organs, 6, 227, 10.1007/s10047-003-0232-x
Heise, 2003, Local haemodynamics and shear stress in cuffed and straight PTFE-venous anastomoses: an in-vitro comparison using particle image velocimetry, Eur J Vasc Endovasc Surg, 26, 367, 10.1016/S1078-5884(03)00243-0
Hofstra, 1994, Mismatch in elastic properties around anastomoses of interposition grafts for hemodialysis access, J Am Soc Nephrol, 5, 1243, 10.1681/ASN.V551243
Keynton, 2001, Intimal hyperplasia and wall shear in arterial bypass graft distal anastomoses: an in vivo model study, J Biomech Eng, 123, 464, 10.1115/1.1389461
Krueger, 2002, Computational fluid dynamics and vascular access, Artif Organs, 26, 571, 10.1046/j.1525-1594.2002.07078.x
Meyerson, 2001, The effects of extremely low shear stress on cellular proliferation and neointimal thickening in the failing bypass graft, J Vasc Surg, 34, 90, 10.1067/mva.2001.114819
Van Tricht, 2006, Comparison of the hemodynamics in 6mm and 4-7 mm hemodialysis grafts by means of CFD, J Biomech, 39, 226, 10.1016/j.jbiomech.2004.12.003
Lee, 2000, Association of artery wall hypoxia and cellular proliferation at a vascular anastomosis, J Surg Res, 91, 32, 10.1006/jsre.2000.5891
Santilli, 2000, Transarterial wall oxygen gradients at a prosthetic vascular graft to artery anastomosis in the rabbit, J Vasc Surg, 31, 1229, 10.1067/mva.2000.104590
Hughes, 2009, Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway—a pilot study, Nephrol Dial Transplant, 24, 85, 10.1093/ndt/gfn433
Misra, 2010, Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency, J Vasc Interv Radiol, 21, 1255, 10.1016/j.jvir.2010.02.043
Lim, 2009, Pathogenesis of primary varicose veins, Br J Surg, 96, 1231, 10.1002/bjs.6798
Taccoen, 1996, Measurement of oxygen tension in normal and varicose vein walls, J Mal Vasc, 21, 259
Lee, 2006, Increased expression of hypoxia-inducible factor-1alpha in the internal spermatic vein of patients with varicocele, J Urol, 175, 1045
Lee, 2012, Increased expression of hypoxia-inducible factor-1alpha and metallothionein in varicocele and varicose veins, Phlebology, 27, 409, 10.1258/phleb.2011.011051
Hossein Ghaderian, 2010, Pathogenic mechanisms in varicose vein disease: the role of hypoxia and inflammation, Pathology, 42, 446, 10.3109/00313025.2010.493865
Elvidge, 2006, Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways, J Biol Chem, 281, 15215, 10.1074/jbc.M511408200
Lim, 2011, Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava, J Vasc Surg, 53, 764, 10.1016/j.jvs.2010.09.018
Hamer, 1981, The PO2 in venous valve pockets: its possible bearing on thrombogenesis, Br J Surg, 68, 166, 10.1002/bjs.1800680308
Sevitt, 1974, The structure and growth of valve-pocket thrombi in femoral veins, J Clin Pathol, 27, 517, 10.1136/jcp.27.7.517
Alikhan, 2008, Epidemiology of venous thromboembolism in cardiorespiratory and infectious disease, Am J Med, 121, 935, 10.1016/j.amjmed.2008.05.045
Nizet, 2009, Interdependence of hypoxic and innate immune responses, Nat Rev Immunol, 9, 609, 10.1038/nri2607
Bovill, 2011, Venous valvular stasis-associated hypoxia and thrombosis: what is the link?, Annu Rev Physiol, 73, 527, 10.1146/annurev-physiol-012110-142305
Henke, 2009, Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes, Thromb Res, 123, S72, 10.1016/S0049-3848(09)70148-3
Moldovan, 2003, Role of blood mononuclear cells in recanalization and vascularization of thrombi: past, present, and future, Trends Cardiovasc Med, 13, 265, 10.1016/S1050-1738(03)00108-7
Meissner, 1993, Deep venous insufficiency: the relationship between lysis and subsequent reflux, J Vasc Surg, 18, 596, 10.1016/0741-5214(93)90069-X
Saarinen, 2000, The occurrence of the post-thrombotic changes after an acute deep venous thrombosis. A prospective two-year follow-up study, J Cardiovasc Surg (Torino), 41, 441
Meissner, 1998, Determinants of chronic venous disease after acute deep venous thrombosis, J Vasc Surg, 28, 826, 10.1016/S0741-5214(98)70057-6
Evans, 2010, Hypoxia and upregulation of hypoxia-inducible factor 1{alpha} stimulate venous thrombus recanalization, Arterioscler Thromb Vasc Biol, 30, 2443, 10.1161/ATVBAHA.110.215038
Evans, 2011, Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution, Thromb Res, 128, 346, 10.1016/j.thromres.2011.05.006
Merrill, 2005, A reassessment of vascular endothelial growth factor in central nervous system pathology, J Neurosurg, 103, 853, 10.3171/jns.2005.103.5.0853
Comati, 2007, Upregulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha in leptomeningeal vascular malformations of Sturge-Weber syndrome, J Neuropathol Exp Neurol, 66, 86, 10.1097/nen.0b013e31802d9011
Takagi, 2011, Expression of thioredoxin-1 and hypoxia inducible factor-1alpha in cerebral arteriovenous malformations: possible role of redox regulatory factor in neoangiogenic property, Surg Neurol Int, 2, 61, 10.4103/2152-7806.80356
Ng, 2005, Hypoxia inducible factor-1alpha and expression of vascular endothelial growth factor and its receptors in cerebral arteriovenous malformations, J Clin Neurosci, 12, 794, 10.1016/j.jocn.2005.02.005
Tirakotai, 2005, Immunohistochemical study in dural arteriovenous fistulas and possible role of local hypoxia for the de novo formation of dural arteriovenous fistulas, Clin Neurol Neurosurg, 107, 455, 10.1016/j.clineuro.2004.11.014
Gao, 2009, Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9, J Cereb Blood Flow Metab, 29, 1482, 10.1038/jcbfm.2009.67
Lu, 2011, Increased endothelial progenitor cells and vasculogenic factors in higher-staged arteriovenous malformations, Plast Reconstr Surg, 128, 260, 10.1097/PRS.0b013e3182268afd
Tan, 2011, The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study, J Dig Dis, 12, 349
Giatromanolaki, 2005, The HIF-2alpha/VEGF pathway activation in cutaneous capillary haemangiomas, Pathology, 37, 149, 10.1080/00313020400025011
Sure, 2005, Biological activity of adult cavernous malformations: a study of 56 patients, J Neurosurg, 102, 342, 10.3171/jns.2005.102.2.0342
Koh, 2010, HIF-1alpha and cancer therapy, Recent Results Cancer Res, 180, 15, 10.1007/978-3-540-78281-0_3
Baldewijns, 2010, VHL and HIF signalling in renal cell carcinogenesis, J Pathol, 221, 125, 10.1002/path.2689
Greenberger, 2008, A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth, Mol Cancer Ther, 7, 3598, 10.1158/1535-7163.MCT-08-0510
Kong, 2005, Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity, Cancer Res, 65, 9047, 10.1158/0008-5472.CAN-05-1235
Myllyharju, 2009, HIF prolyl 4-hydroxylases and their potential as drug targets, Curr Pharm Des, 15, 3878, 10.2174/138161209789649457
Harten, 2010, Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection, Antioxid Redox Signal, 12, 459, 10.1089/ars.2009.2870
Nangaku, 2006, Novel drugs and the response to hypoxia: HIF stabilizers and prolyl hydroxylase, Recent Pat Cardiovasc Drug Discov, 1, 129, 10.2174/157489006777442522
Cases, 2007, The latest advances in kidney diseases and related disorders, Drug News Perspect, 20, 647