EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells

Adkison, 2006, Differential responses of pulmonary endothelial phenotypes to cyclical stretch, Microvasc. Res., 71, 175, 10.1016/j.mvr.2006.02.007 Alkayed, 2002, Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack, Stroke, 33, 1677, 10.1161/01.STR.0000016332.37292.59 Bao, 2013, Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-kappaB pathway, J. Ethnopharmacol., 146, 543, 10.1016/j.jep.2013.01.019 Buczynski, 2009, Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology, J. Lipid Res., 50, 1015, 10.1194/jlr.R900004-JLR200 Capdevila, 2002, Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases, Prostaglandins Other Lipid Mediat., 68–69, 325, 10.1016/S0090-6980(02)00038-2 De Martin, 2000, The transcription factor NF-kappa B and the regulation of vascular cell function, Arterioscler. Thromb. Vasc. Biol., 20, E83, 10.1161/01.ATV.20.11.e83 Fang, 2012, Chronic intermittent hypoxia exposure induces atherosclerosis in ApoE knockout mice: role of NF-kappaB p50, Am. J. Pathol., 181, 1530, 10.1016/j.ajpath.2012.07.024 Feng, 2012, Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea, Sleep Breath., 16, 283, 10.1007/s11325-011-0519-8 Feng, 2013, EETs and CYP2J2 inhibit TNF-alpha-induced apoptosis in pulmonary artery endothelial cells and TGF-beta1-induced migration in pulmonary artery smooth muscle cells, Int. J. Mol. Med., 32, 685, 10.3892/ijmm.2013.1435 Fleming, 2007, DiscrEET regulators of homeostasis: epoxyeicosatrienoic acids, cytochrome P450 epoxygenases and vascular inflammation, Trends Pharmacol. Sci., 28, 448, 10.1016/j.tips.2007.08.002 Iliff, 2009, Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels, Am. J. Physiol. Heart Circ. Physiol., 296, H1352, 10.1152/ajpheart.00950.2008 Jian, 2008, High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4, Am. J. Respir. Cell Mol. Biol., 38, 386, 10.1165/rcmb.2007-0192OC Jubeli, 2012, E-selectin as a target for drug delivery and molecular imaging, J. Control Release., 158, 194, 10.1016/j.jconrel.2011.09.084 Karara, 1993, Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase, J. Biol. Chem., 268, 13565, 10.1016/S0021-9258(19)38686-7 Keseru, 2010, Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition, Cardiovasc. Res., 85, 232, 10.1093/cvr/cvp281 Landsberger, 2010, Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats, Crit. Care., 14, R223, 10.1186/cc9367 Lawson, 2009, ICAM-1 signaling in endothelial cells, Pharmacol. Rep., 61, 22, 10.1016/S1734-1140(09)70004-0 Li, 2007, Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia, J. Appl. Physiol., 102, 557, 10.1152/japplphysiol.01081.2006 Ling, 2012, Cell adhesion molecules as pharmaceutical target in atherosclerosis, Mini Rev. Med. Chem., 12, 175, 10.2174/138955712798995057 Liu, 2011, Protective effect of alpha-lipoic acid on oxidized low density lipoprotein-induced human umbilical vein endothelial cell injury, Pharmacol. Rep., 63, 1180, 10.1016/S1734-1140(11)70637-5 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262 Lupo, G., Nicotra, A., Giurdanella, G., Anfuso, C.D., Romeo, L., Biondi,G., Tirolo,C., Marchetti, B., Ragusa, N., and Alberghina, M., 2005. Activation of phospholipase A(2) and MAP kinases by oxidized low-density lipoproteins in immortalized GP8.39 endothelial cells. Biochim. Biophys. Acta 1735, 135-150. Mitra, 2011, Oxidized LDL, LOX-1 and atherosclerosis, Cardiovasc. Drugs Ther., 25, 419, 10.1007/s10557-011-6341-5 Nelken, 1991, Monocyte chemoattractant protein-1 in human atheromatous plaques, J. Clin. Invest., 88, 1121, 10.1172/JCI115411 Nelson, 2009, The cytochrome p450 homepage, Hum. Genomics, 4, 59, 10.1186/1479-7364-4-1-59 Node, 1999, Anti-inflammatory properties of cytochrome P450epoxygenase-derived eicosanoids, Science, 285, 1276, 10.1126/science.285.5431.1276 Park, 2009, Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-kappaB activation, Arch. Pharm. Res., 32, 583, 10.1007/s12272-009-1415-7 Pasceri, 2000, Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators, Circulation, 101, 235, 10.1161/01.CIR.101.3.235 Pfister, 2010, Vascular pharmacology of epoxyeicosatrienoic acids, Adv. Pharmacol., 60, 27, 10.1016/B978-0-12-385061-4.00002-7 Revermann, 2009, Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats, J. Hypertens., 27, 322, 10.1097/HJH.0b013e32831aedfa Roldan, 2003, Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature, Thromb. Haemost., 90, 1007, 10.1160/TH02-09-0083 Sajkov, 2009, Obstructive sleep apnea and pulmonary hypertension, Prog. Cardiovasc. Dis., 51, 363, 10.1016/j.pcad.2008.06.001 Savransky, 2007, Chronic intermittent hypoxia predisposes to liver injury, Hepatology, 45, 1007, 10.1002/hep.21593 Smith, 2005, Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor, Proc. Natl. Acad. Sci. USA, 102, 2186, 10.1073/pnas.0409591102 Spiecker, 2005, Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids, Arch. Biochem. Biophys., 433, 413, 10.1016/j.abb.2004.10.009 Sung, 2001, Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis, Mol. Cell Biochem., 216, 121, 10.1023/A:1017383916068 Tanigawa, 2006, Dominant-negative lox-1 blocks homodimerization of wild-type lox-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation, Hypertension, 48, 294, 10.1161/01.HYP.0000229825.98545.5e Tanigawa, 2006, Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1, Atherosclerosis, 188, 245, 10.1016/j.atherosclerosis.2005.10.046 Thomson, 2012, Anti-inflammatory effects of epoxyeicosatrienoic acids, Int. J. Vasc. Med., 2012, 605101 Urban, 1991, NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit, EMBO J., 10, 1817, 10.1002/j.1460-2075.1991.tb07707.x Vermeulen, 2002, Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit, Biochem. Pharmacol., 64, 963, 10.1016/S0006-2952(02)01161-9 Wang, 2013, 6-Shogaol protects against oxidized LDL-induced endothelial injruries by inhibiting oxidized LDL-evoked LOX-1 signaling, Evid. Based Complement Altern. Med., 2013, 503521, 10.1155/2013/503521 Wiesner, 2013, MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma, J. Lipid Res., 54, 1877, 10.1194/jlr.M036343 Williams, 2010, 20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension, J. Cardiovasc. Pharmacol., 56, 336, 10.1097/FJC.0b013e3181f04b1c Xu, 2011, The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases, Adv. Drug Deliv. Rev., 63, 597, 10.1016/j.addr.2011.03.006 Yadav, 2010, MCP-1: chemoattractant with a role beyond immunity: a review, Clin. Chim. Acta, 411, 1570, 10.1016/j.cca.2010.07.006 Yaghi, 2004, Excess nitric oxide decreases cytochrome P-450 2J4 content and P-450-dependent arachidonic acid metabolism in lungs of rats with acute pneumonia, Am. J. Physiol. Lung Cell Mol. Physiol., 286, L1260, 10.1152/ajplung.00273.2003 Yaghi, 2003, Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia, Am. J. Physiol. Lung Cell Mol. Physiol., 285, L1099, 10.1152/ajplung.00039.2003 Zhang, 2012, Olmesartan attenuates the impairment of endothelial cells induced by oxidized low density lipoprotein through downregulating expression of LOX-1, Int. J. Mol. Sci., 13, 1512, 10.3390/ijms13021512 Zhang, 2013, Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1, Arch. Med. Res., 44, 13, 10.1016/j.arcmed.2012.12.001 Zhang, 2011, Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells, J. Cardiovasc. Pharmacol., 57, 721, 10.1097/FJC.0b013e31821a50a8 Zhao, 2012, Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis, Hum. Gene Ther., 23, 688, 10.1089/hum.2011.135 Zhao, 2008, Protective effects of aspirin against oxidized LDL-induced inflammatory protein expression in human endothelial cells, J. Cardiovasc. Pharmacol., 51, 32, 10.1097/FJC.0b013e318159ebaf Zheng, 2010, Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats, Am. J. Respir. Cell Mol. Biol., 43, 740, 10.1165/rcmb.2009-0161OC