The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 Campagnolo, 2005, EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury, Am. J. Pathol., 167, 275, 10.1016/S0002-9440(10)62972-0 Carmeliet, 2003, Angiogenesis in health and disease, Nat. Med., 9, 653, 10.1038/nm0603-653 Chang, 2005, An expression screen reveals modulators of class II histone deacetylase phosphorylation, Proc. Natl. Acad. Sci. USA, 102, 8120, 10.1073/pnas.0503275102 Chang, 2006, Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10, Cell, 126, 321, 10.1016/j.cell.2006.05.040 Cross, 2001, FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition, Trends Pharmacol. Sci., 22, 201, 10.1016/S0165-6147(00)01676-X Eliceiri, 1998, Integrin α v β 3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis, J. Cell Biol., 140, 1255, 10.1083/jcb.140.5.1255 Fitch, 2004, Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells, Dev. Dyn., 230, 316, 10.1002/dvdy.20063 Garzon, 2006, MicroRNA fingerprints during human megakaryocytopoiesis, Proc. Natl. Acad. Sci. USA, 103, 5078, 10.1073/pnas.0600587103 Giroux, 1999, Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta, Curr. Biol., 9, 369, 10.1016/S0960-9822(99)80164-X Harris, 2008, MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1, Proc. Natl. Acad. Sci. USA, 105, 1516, 10.1073/pnas.0707493105 Hayashi, 2004, Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure, J. Clin. Invest., 113, 1138, 10.1172/JCI200419890 He, 2004, MicroRNAs: small RNAs with a big role in gene regulation, Nat. Rev. Genet., 5, 522, 10.1038/nrg1379 Hood, 2002, Tumor regression by targeted gene delivery to the neovasculature, Science, 296, 2404, 10.1126/science.1070200 Jackson, 2007, How do microRNAs regulate gene expression?, Sci. STKE, 367, re1 John, 2008, Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1, J. Biol. Chem., 283, 951, 10.1074/jbc.M705262200 Kocher, 2001, Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function, Nat. Med., 7, 430, 10.1038/86498 Kothary, 1989, Inducible expression of an Hsp68-Lacz hybrid gene in transgenic mice, Development, 105, 707, 10.1242/dev.105.4.707 Kuehbacher, 2007, Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis, Circ. Res., 101, 59, 10.1161/CIRCRESAHA.107.153916 Kutryk, 2003, Angiogenesis of the heart, Microsc. Res. Tech., 60, 138, 10.1002/jemt.10252 Lagos-Quintana, 2002, Identification of tissue-specific microRNAs from mouse, Curr. Biol., 12, 735, 10.1016/S0960-9822(02)00809-6 Landgraf, 2007, A mammalian microRNA expression atlas based on small RNA library sequencing, Cell, 129, 1401, 10.1016/j.cell.2007.04.040 Latronico, 2007, Emerging role of MicroRNAs in cardiovascular biology, Circ. Res., 101, 1225, 10.1161/CIRCRESAHA.107.163147 Lelievre, 2001, Role of the ETS transcription factors in the control of endothelial-specific gene expression and in angiogenesis, Bull. Cancer, 88, 137 Miyoshi, 2004, The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization, Oncogene, 23, 5567, 10.1038/sj.onc.1207759 Musiyenko, 2008, Ectopic expression of miR-126∗, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells, J. Mol. Med., 86, 313, 10.1007/s00109-007-0296-9 Nonami, 2004, Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells, J. Biol. Chem., 279, 52543, 10.1074/jbc.M405189200 Panka, 2006, Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma, Clin. Cancer Res., 12, 2371s, 10.1158/1078-0432.CCR-05-2539 Parker, 2004, The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation, Nature, 428, 754, 10.1038/nature02416 Scheinowitz, 1997, The role of insulin-like and basic fibroblast growth factors on ischemic and infarcted myocardium: A mini review, Int. J. Cardiol., 59, 1, 10.1016/S0167-5273(96)02902-6 Schmidt, 2007, EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution, Development, 134, 2913, 10.1242/dev.002576 Semenza, 2003, Angiogenesis in ischemic and neoplastic disorders, Annu. Rev. Med., 54, 17, 10.1146/annurev.med.54.101601.152418 Soncin, 2003, VE-statin, an endothelial repressor of smooth muscle cell migration, EMBO J., 22, 5700, 10.1093/emboj/cdg549 Suarez, 2007, Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells, Circ. Res., 100, 1164, 10.1161/01.RES.0000265065.26744.17 Syed, 2004, Therapeutic angiogenesis: A biologic bypass, Cardiology, 101, 131, 10.1159/000075994 Takahashi, 1999, Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization, Nat. Med., 5, 434, 10.1038/8462 Tavazoie, 2008, Endogenous human microRNAs that suppress breast cancer metastasis, Nature, 451, 147, 10.1038/nature06487 van Rooij, 2007, MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets, J. Clin. Invest., 117, 2369, 10.1172/JCI33099 van Rooij, 2007, Control of stress-dependent cardiac growth and gene expression by a microRNA, Science, 316, 575, 10.1126/science.1139089 Wakioka, 2001, Spred is a Sprouty-related suppressor of Ras signalling, Nature, 412, 647, 10.1038/35088082 Wang, 2008, Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7, Proc. Natl. Acad. Sci. USA, 105, 7738, 10.1073/pnas.0802857105 Wienholds, 2005, MicroRNA expression in zebrafish embryonic development, Science, 309, 310, 10.1126/science.1114519