Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

Bai, 2010, TIF1γ controls erythroid cell fate by regulating transcription elongation, Cell, 142, 133, 10.1016/j.cell.2010.05.028 Chakravarty, 2009, Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator, Structure, 17, 670, 10.1016/j.str.2009.02.017 Chignola, 2009, The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation, Nucleic Acids Res., 37, 2951, 10.1093/nar/gkp166 Dennler, 1998, Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene, EMBO J., 17, 3091, 10.1093/emboj/17.11.3091 Dupont, 2005, Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase, Cell, 121, 87, 10.1016/j.cell.2005.01.033 Dupont, 2009, FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination, Cell, 136, 123, 10.1016/j.cell.2008.10.051 Groner, 2010, KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading, PLoS Genet., 6, e1000869, 10.1371/journal.pgen.1000869 Hager, 2009, Transcription dynamics, Mol. Cell, 35, 741, 10.1016/j.molcel.2009.09.005 He, 2006, Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFbeta pathway, Cell, 125, 929, 10.1016/j.cell.2006.03.045 Inman, 2002, Stoichiometry of active smad-transcription factor complexes on DNA, J. Biol. Chem., 277, 51008, 10.1074/jbc.M208532200 Inman, 2002, SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, Mol. Pharmacol., 62, 65, 10.1124/mol.62.1.65 Ivanov, 2007, PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing, Mol. Cell, 28, 823, 10.1016/j.molcel.2007.11.012 Jain, 2009, Regulation of p53: TRIM24 enters the RING, Cell Cycle, 8, 3668, 10.4161/cc.8.22.9979 Jenuwein, 2001, Translating the histone code, Science, 293, 1074, 10.1126/science.1063127 Khetchoumian, 2004, TIF1δ, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids, J. Biol. Chem., 279, 48329, 10.1074/jbc.M404779200 Korchynskyi, 2002, Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter, J. Biol. Chem., 277, 4883, 10.1074/jbc.M111023200 Le Scolan, 2008, Transforming growth factor-β suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation, Cancer Res., 68, 3277, 10.1158/0008-5472.CAN-07-6793 Levy, 2005, Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses, Mol. Cell. Biol., 25, 8108, 10.1128/MCB.25.18.8108-8125.2005 Levy, 2007, Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation, Mol. Cell. Biol., 27, 6068, 10.1128/MCB.00664-07 Li, 2006, Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF, Nature, 442, 91, 10.1038/nature04802 Luger, 1997, Characterization of nucleosome core particles containing histone proteins made in bacteria, J. Mol. Biol., 272, 301, 10.1006/jmbi.1997.1235 Meroni, 2005, TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases, Bioessays, 27, 1147, 10.1002/bies.20304 Morinière, 2009, Cooperative binding of two acetylation marks on a histone tail by a single bromodomain, Nature, 461, 664, 10.1038/nature08397 Morsut, 2010, Negative control of Smad activity by ectodermin/Tif1γ patterns the mammalian embryo, Development, 137, 2571, 10.1242/dev.053801 Peng, 2000, Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions, J. Mol. Biol., 295, 1139, 10.1006/jmbi.1999.3402 Posern, 2006, Actin' together: serum response factor, its cofactors and the link to signal transduction, Trends Cell Biol., 16, 588, 10.1016/j.tcb.2006.09.008 Ross, 2006, Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription, EMBO J., 25, 4490, 10.1038/sj.emboj.7601332 Ruthenburg, 2007, Multivalent engagement of chromatin modifications by linked binding modules, Nat. Rev. Mol. Cell Biol., 8, 983, 10.1038/nrm2298 Schmierer, 2005, Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor β-dependent nuclear accumulation of Smads, Mol. Cell. Biol., 25, 9845, 10.1128/MCB.25.22.9845-9858.2005 Schmierer, 2007, TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility, Nat. Rev. Mol. Cell Biol., 8, 970, 10.1038/nrm2297 Schmierer, 2008, Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system, Proc. Natl. Acad. Sci. USA, 105, 6608, 10.1073/pnas.0710134105 Stavreva, 2004, Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes, Mol. Cell. Biol., 24, 2682, 10.1128/MCB.24.7.2682-2697.2004 Taverna, 2006, Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs, Mol. Cell, 24, 785, 10.1016/j.molcel.2006.10.026 Taverna, 2007, How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers, Nat. Struct. Mol. Biol., 14, 1025, 10.1038/nsmb1338 Wang, 2008, Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes, Biochem. Biophys. Res. Commun., 376, 288, 10.1016/j.bbrc.2008.08.143 Wu, 2009, Tgf-β superfamily signaling in embryonic development and homeostasis, Dev. Cell, 16, 329, 10.1016/j.devcel.2009.02.012 Wu, 2011, SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos, PLoS Biol., 9, e1000593, 10.1371/journal.pbio.1000593