Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease

Free Radical Biology and Medicine - Tập 37 - Trang 1499-1507 - 2004
Luis A. Videla1, Ramón Rodrigo1, Julia Araya2, Jaime Poniachik3
1Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile
2Departamento de Nutrición, Facultad de Medicina, Chile
3Unidad de Gastroenterología, Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Santiago-7, Chile

Tài liệu tham khảo

Chitturi, 2001, Etiopathogenesis of nonalcoholic steatohepatitis, Semin. Liver Dis., 21, 27, 10.1055/s-2001-12927 Angulo, 2002, Nonalcoholic fatty liver disease, N. Engl. J. Med., 346, 1221, 10.1056/NEJMra011775 Matteoni, 1999, Nonalcoholic fatty liver disease: a spectrum of clinical pathological severity, Gastroenterology, 116, 1413, 10.1016/S0016-5085(99)70506-8 Kuwajima, 1991, Animal model of systemic carnitine deficiency: analysis in C3H-2 strain of mouse associated with juvenile visceral steatosis, Biochem. Biophys. Res. Commun., 174, 1090, 10.1016/0006-291X(91)91532-H Bjorkegren, 2002, Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury, J. Biol. Chem., 277, 5476, 10.1074/jbc.M108514200 Sessler, 1998, Polyunsaturated fatty acid regulation of gene expression, J. Nutr., 128, 923, 10.1093/jn/128.6.923 Nakamura, 2000, Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice, J. Nutr., 130, 1561, 10.1093/jn/130.6.1561 Clarke, 2001, Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome, J. Nutr., 131, 1129, 10.1093/jn/131.4.1129 Reddy, 2001, Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis, Am. J. Physiol., 281, G1333 Mahfouz, 1984, Effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat-liver microsomes, Lipids, 19, 214, 10.1007/BF02534800 Sies, 1986, Biochemistry of oxidative stress, Angew. Chem. Int. Ed. Engl., 25, 1058, 10.1002/anie.198610581 Sevanian, 1985, Mechanisms and consequences of lipid peroxidation in biological systems, Ann. Rev. Nutr., 5, 365, 10.1146/annurev.nu.05.070185.002053 Araya, 2004, Increase in long-chain polyunsaturated fatty acids n-6/n-3 ratio in relation to hepatic steatosis in nonalcoholic fatty liver disease patients, Clin. Sci., 106, 635, 10.1042/CS20030326 Yoshikawa, 2002, Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements, J. Biol. Chem., 277, 1705, 10.1074/jbc.M105711200 Matsuzaka, 2002, Dual regulation of mouse delta(5)- and delta(6)-desaturase gene expression by SREBP-1 and PPARalpha, J. Lipid Res., 43, 107, 10.1016/S0022-2275(20)30193-0 Osborne, 2000, Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action, J. Biol. Chem., 275, 32379, 10.1074/jbc.R000017200 Clarke, 1999, Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors, Am. J. Clin. Nutr., 70, 566, 10.1093/ajcn/70.4.566 Kersten, 2002, Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha, and sterol regulatory-element binding protein-1c, Proc. Nutr. Soc., 61, 371, 10.1079/PNS2002169 Lindén, 2002, Influence of peroxisome proliferator-activated receptor α agonists on the intracellular turnover and secretion of apolipoprotein (Apo)B-100 and ApoB-48, J. Biol. Chem., 277, 23044, 10.1074/jbc.M110416200 Charlton, 2002, Apolipoprotein synthesis in nonalcoholic steatohepatitis, Hepatology, 35, 898, 10.1053/jhep.2002.32527 Meunier-Durmort, 1996, Upregulation of the expression of the gene for liver fatty acid-binding protein by long-chain fatty acids, Biochem. J., 319, 483, 10.1042/bj3190483 Carlsson, 2001, Effects of fatty acids and growth hormone on liver fatty acid-binding protein and PPARα in rat liver, Am. J. Physiol., 281, E772 Kersten, 1999, Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting, J. Clin. Invest., 103, 1489, 10.1172/JCI6223 Baylin, 2002, Adipose tissue biomarkers of fatty acid intake, Am. J. Clin. Nutr., 76, 750, 10.1093/ajcn/76.4.750 Larqué, 2000, Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats, Pediatr. Res., 47, 278, 10.1203/00006450-200002000-00021 Burke, 1999, Conditionally essential fatty acid deficiencies in end-stage liver disease, Nutrition, 15, 302, 10.1016/S0899-9007(99)00002-7 Okita, 2002, Habitual food intake and polyunsaturated fatty acid deficiency in liver cirrhosis, Nutrition, 18, 304, 10.1016/S0899-9007(01)00756-0 Videla, 1995, Biochemical mechanisms in hepatotoxicity: oxidative stress induced by xenobiotics and hormonal changes, J. Braz. Assoc. Adv. Sci., 47, 385 Jaeschke, 2002, Mechanisms of hepatotoxicity, Toxicol. Sci., 65, 166, 10.1093/toxsci/65.2.166 Tsukamoto, 2002, Redox regulation of cytokine expression in Kupffer cells, Antioxid. Redox Signaling, 4, 741, 10.1089/152308602760598882 Martindale, 2002, Cellular responses to oxidative stress: signaling for suicide and survival, J. Cell. Physiol., 192, 1, 10.1002/jcp.10119 Klatt, 2000, Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress, Eur. J. Biochem., 267, 4928, 10.1046/j.1432-1327.2000.01601.x Videla, 2004, Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients, Clin. Sci., 106, 261, 10.1042/CS20030285 Cortez-Pinto, 1999, A peroxidação dos lípidos na esteatohepatite não alcoólica: relação com a esteatose, J. Português Gastroenterol., 6, 234 Loguercio, 2001, Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects, J. Hepatol., 35, 568, 10.1016/S0168-8278(01)00192-1 Sanyal, 2001, Nonalcoholic steatohepatitis: association with insulin resistance and mitochondrial abnormalities, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256 García-Monzón, 2000, Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity, J. Hepatol., 33, 716, 10.1016/S0168-8278(00)80301-3 Seki, 2002, In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases, J. Hepatol., 37, 56, 10.1016/S0168-8278(02)00073-9 Stadtman, 1990, Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences, Free Radic. Biol. Med., 9, 315, 10.1016/0891-5849(90)90006-5 Chalasani, 2003, Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis, Hepatology, 37, 544, 10.1053/jhep.2003.50095 Weltman, 1998, Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis, Hepatology, 27, 128, 10.1002/hep.510270121 Lucas, 1998, Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation, Fundam. Clin. Pharmacol., 12, 553, 10.1111/j.1472-8206.1998.tb00985.x de la Maza, 2000, Changes in microsomal activity in alcoholism and obesity, Alcohol. Clin. Exp. Res., 24, 605, 10.1111/j.1530-0277.2000.tb02031.x Lieber, 1997, Cytochrome P-4502E1: its physiological and pathological role, Physiol. Rev., 77, 517, 10.1152/physrev.1997.77.2.517 Zangar, 1997, Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes, Arch. Biochem. Biophys., 337, 217, 10.1006/abbi.1996.9785 Song, 1989, Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization, J. Biol. Chem., 264, 3568, 10.1016/S0021-9258(18)94103-7 Robertson, 2001, Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress, Am. J. Physiol. Gastrointest. Liver Physiol., 281, G1135, 10.1152/ajpgi.2001.281.5.G1135 Koteish, 2001, Animal models of steatosis, Semin. Liver Dis., 21, 89, 10.1055/s-2001-12932 Kaplan, 1998, Leptin, obesity, and liver disease, Gastroenterology, 115, 997, 10.1016/S0016-5085(98)70272-0 Neuschwander-Tetri, 2003, Nonalcoholic steatohepatitis: summary of an AASLD single topic conference, Hepatology, 37, 1202, 10.1053/jhep.2003.50193 Crespo, 2001, Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients, Hepatology, 34, 1158, 10.1053/jhep.2001.29628 Wigg, 2001, The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxemia, and tumor necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis, Gut, 48, 206, 10.1136/gut.48.2.206 Kugelmas, 2003, Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E, Hepatology, 38, 413, 10.1053/jhep.2003.50316 Schulze-Osthoff, 1992, Cytotoxic activity of tumor necrosis factor is mediated by early damage to mitochondrial functions, J. Biol. Chem., 267, 5317, 10.1016/S0021-9258(18)42768-8 Caldwell, 1999, Mitochondrial abnormalities in non-alcoholic steatohepatitis, J. Hepatol., 31, 430, 10.1016/S0168-8278(99)80033-6 Cortéz-Pinto, 1999, Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study, JAMA, 282, 1659, 10.1001/jama.282.17.1659 Delerive, 2001, Peroxisome proliferator-activated receptors in inflammation control, J. Endocrinol., 169, 453, 10.1677/joe.0.1690453 Lavine, 2000, Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study, J. Pediatr., 136, 734, 10.1067/mpd.2000.106566 Hasegawa, 2001, Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study, Aliment. Pharmacol. Ther., 15, 1667, 10.1046/j.1365-2036.2001.01083.x Sekiya, 2003, Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression, Hepatology, 38, 1529, 10.1016/j.hep.2003.09.028 Ip, 2003, Central role of PPAR-α-dependent hepatic lipid turnover in dietary steatohepatitis in mice, Hepatology, 38, 123, 10.1053/jhep.2003.50307 Uesugi, 2001, Delivery of IκB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats, Hepatology, 34, 1149, 10.1053/jhep.2001.29400 Aleynik, 1999, Dilinoleoylphosphatidylcholine is the active antioxidant of polyenylphosphatidylcholine, J. Invest. Med., 47, 507 Aleynik, 2003, Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring S-adenosylmethionine, Alcohol Alcohol., 38, 208, 10.1093/alcalc/agg066