TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer

Cancer Letters - Tập 499 - Trang 137-147 - 2021
Hye Sook Han1,2, Seongju Jeong3, Hyunglae Kim3, Hyung-Don Kim3, A.Reum Kim3, Minsuk Kwon3, Su-Hyung Park3, Chang Gok Woo4, Hee Kyung Kim2, Ki Hyeong Lee1,2, Sung Pil Seo5, Ho Won Kang5,6, Won Tae Kim5,6, Wun-Jae Kim5,6, Seok Joong Yun5,6, Eui-Cheol Shin3
1Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea
2Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea
3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
4Department of Pathology, Chungbuk National University Hospital, Cheongju, Republic of Korea
5Department of Urology, Chungbuk National University Hospital, Cheongju, Republic of Korea
6Department of Urology, Chungbuk National University College of Medicine, Cheongju, Republic of Korea

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