Histoanatomy of anal glands
Tóm tắt
PURPOSE: This study was designed to investigate the histology of adult anal glands using conventional as well as immunochemical methods. METHODS: Fifteen fresh human ani were prepared and stained with conventional and immunohistologic stains. RESULTS: The median number of anal glands in each anus was six (range, 3–10). Sixty-eight (80 percent) of 85 anal glands found were submucosal in extent, seven (8 percent) extended to the circular internal sphincter, seven (8 percent) to the longitudinal internal sphincter, two (2 percent) to the intersphincteric space, and only one (1 percent) penetrated the external anal sphincter. Ampulla-like dilations were noted in anal glands from ten patients only, occurring at the submucosal level in seven ani and at the circular internal sphincter in three ani. Lymphocytic infiltrations were noted around the glands in all ani studied. Mucus-secreting cells were found in all ani, and many glands showed the presence of intraluminal secretions. Immunostaining for smooth muscle actin showed the presence of one to two cell layers of myoepithelial cells surrounding all anal glands. CONCLUSIONS: Anal glands are definite preformed structures with secretory activity.
Tài liệu tham khảo
Seow-Choen F, Nicholls RJ. Anal fistula. Br J Surg 1992;79:197–205.
Hill MR, Shryock EH, Rebell FG. Role of the anal glands in the pathogenesis of anorectal disease. JAMA 1943;121:742–6.
Hill MR, Small CS, Hunt GM, Richards LJ. Development of anal ducts and glands with reference to the pathogenesis of anorectal disease. Arch Pathol 1949;47:350–60.
Lilius HG. Fistula-in-ano: an investigation of human foetal anal ducts and intramuscular glands and a clinical study of 150 patients. Acta Chir Scand [Suppl] 1968;383:1–88.
Kratzer GL, Dockerty MB. Histopathology of the anal duct. Surg Gynecol Obstet 1947;84:333–8.
Morgan CN. Surgical anatomy of the anal canal and rectum. Postgrad Med J 1936;12:287–300.
Kuster GG. Relationship of anal glands to lymphatics. Dis Colon Rectum 1965;8:329–33.
Burke RM, Zavela D, Kaump DH. Significance of the anal gland. Am J Surg 1951;82:659–62.
Parks AG. Pathogenesis and treatment of fistula-in-ano. BMJ 1961;1:463–9.
Fenger F, Filipe MI. Pathology of the anal glands with special reference to their mucin histochemistry. Acta Pathol Microbiol Scand (Sect A) 1977;85:273–85.
Goligher JC. Surgery of the anus, rectum and colon. 3rd ed. London: Balliere Tindall, 1975.
Johnson FP. The development of the rectum in the human embryo. Am J Anat 1914;16:1–57.
Shafik A. A new concept of the anatomy of the anal sphincter mechanism and the physiology of defecation. X. Anorectal sinus and band: anatomic nature and surgical significance. Dis Colon Rectum 1980;23:170–9.
Klosterhalfen B, Offner F, Vogel P, Kirkpatrick CJ. Anatomic nature and surgical significance of anl sinus and anal intramuscular glands. Dis Colon Rectum 1991;34:156–60.
Tucker CC, Hellwig CA. Histopathology of anal crypts. Surg Gynecol Obstet 1933;58:145–9.
Tucker CC, Hellwig CA. Anal ducts: comparative and developmental histology. Arch Surg 1935;31:521–30.
Herrmann G, Desfossess L. La sur la muquese de la region cloacle du rectum. C R Acad Sci III 1880;90:1301–2.
McColl I. The comparative anatomy and pathology of anal glands. Ann R Coll Surg Engl 1967;40:36–67.