MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions

Amir, 1999, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2, Nat. Genet., 23, 185, 10.1038/13810 Armstrong, 2002, Neuropathology of Rett syndrome, Ment. Retard. Dev. Disabil. Res. Rev., 8, 72, 10.1002/mrdd.10027 Armstrong, 1995, Selective dendritic alterations in the cortex of Rett syndrome, J. Neuropathol. Exp. Neurol., 54, 195, 10.1097/00005072-199503000-00006 Bauman, 1995, Microscopic observations of the brain in Rett syndrome, Neuropediatrics, 26, 105, 10.1055/s-2007-979737 Bauman, 1995, Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome, Neurology, 45, 1581, 10.1212/WNL.45.8.1581 Belichenko, 1994, Rett syndrome: 3-D confocal microscopy of cortical pyramidal dendrites and afferents, NeuroReport, 5, 1509, 10.1097/00001756-199407000-00025 Bird, 2002, DNA methylation patterns and epigenetic memory, Genes Dev., 16, 6, 10.1101/gad.947102 Cameron, 1998, Stem cells and neurogenesis in the adult brain, Curr. Opin. Neurobiol., 8, 677, 10.1016/S0959-4388(98)80099-8 Casanova, 1991, Quantitative magnetic resonance imaging in Rett syndrome, J. Neuropsychiatry Clin. Neurosci., 3, 66, 10.1176/jnp.3.1.66 Cassel, 2004, Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study, Neurobiol. Dis., 15, 206, 10.1016/j.nbd.2003.10.011 Chen, 2001, Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice, Nat. Genet., 27, 327, 10.1038/85906 Chen, 2003, Depression of BDNF Transcription involves calcium-dependent phosphorylation of MECP2, Science, 302, 885, 10.1126/science.1086446 Christodoulou, 2003, RettBASE: the IRSA MECP2 variation database—A new mutation database in evolution, Hum. Mutat., 21, 466, 10.1002/humu.10194 Cohen, 2003, Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis, Mol. Cell. Neurosci., 22, 417, 10.1016/S1044-7431(03)00026-5 Conti, 1994, The neurotransmitters and postsynaptic actions of callosally projecting neurons, Behav. Brain Res., 64, 37, 10.1016/0166-4328(94)90117-1 Coy, 1999, A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3″-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression, Hum. Mol. Genet., 8, 1253, 10.1093/hmg/8.7.1253 Debus, 1983, Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides, Differentiation, 25, 193, 10.1111/j.1432-0436.1984.tb01355.x Egaas, 1995, Reduced size of corpus callosum in autism, Arch. Neurol., 52, 794, 10.1001/archneur.1995.00540320070014 Escayg, 2000, Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2, Nat. Genet., 24, 343, 10.1038/74159 Floeter, 1985, The morphology and phased outgrowth of callosal axons in the fetal rat, Brain Res., 354, 7, 10.1016/0165-3806(85)90064-1 Francis, 1999, Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons, Neuron, 23, 247, 10.1016/S0896-6273(00)80777-1 Frotscher, 1998, Cajal–Retzius cells, Reelin, and the formation of layers, Curr. Opin. Neurobiol., 8, 570, 10.1016/S0959-4388(98)80082-2 Gage, 2000, Mammalian neural stem cells, Science, 287, 1433, 10.1126/science.287.5457.1433 Gates, 2000, Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo, Neuroscience, 98, 437, 10.1016/S0306-4522(00)00106-8 Georgel, 2003, Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation, J. Biol. Chem., 278, 32181, 10.1074/jbc.M305308200 Glaze, 2002, Neurophysiology of Rett syndrome, Ment. Retard. Dev. Disabil. Res. Rev., 8, 66, 10.1002/mrdd.10024 Gleeson, 1999, Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons, Neuron, 23, 257, 10.1016/S0896-6273(00)80778-3 Gorski, 2003, Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites, J. Neurosci., 23, 6856, 10.1523/JNEUROSCI.23-17-06856.2003 Gotoh, 2001, Magnetic resonance imaging and clinical findings examined in adulthood-studies on three adults with Rett syndrome, Brain Dev., 23, S118, 10.1016/S0387-7604(01)00355-2 Guy, 2001, A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome, Nat. Genet., 27, 322, 10.1038/85899 Hagberg, 2002, Clinical manifestations and stages of Rett syndrome, Ment. Retard. Dev. Disabil. Res. Rev., 8, 61, 10.1002/mrdd.10020 Hulspas, 1997, In vitro cell density-dependent clonal growth of EGF-responsive murine neural progenitor cells under serum-free conditions, Exp. Neurol., 148, 147, 10.1006/exnr.1997.6672 Jessell, 2000, Development. The decade of the developing brain, Curr. Opin. Neurobiol., 10, 599, 10.1016/S0959-4388(00)00136-7 Johe, 1996, Single factors direct the differentiation of stem cells from the fetal and adult central nervous system, Genes Dev., 10, 3129, 10.1101/gad.10.24.3129 Jung, 2003, The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells, J. Neurobiol., 55, 86, 10.1002/neu.10201 Kligman, 1988, The S100 protein family, Trends Biochem. Sci., 13, 437, 10.1016/0968-0004(88)90218-6 Kriaucionis, 2003, DNA methylation and Rett syndrome, Hum. Mol. Genet., 12, R221, 10.1093/hmg/ddg286 Kriaucionis, 2004, The major form of MeCP2 has a novel N-terminus generated by alternative splicing, Nucleic Acids Res., 32, 1818, 10.1093/nar/gkh349 Lendahl, 1990, CNS stem cells express a new class of intermediate filament protein, Cell, 60, 585, 10.1016/0092-8674(90)90662-X Lewis, 1992, Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA, Cell, 69, 905, 10.1016/0092-8674(92)90610-O Luikenhuis, 2004, Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice, Proc. Natl. Acad. Sci. U. S. A., 101, 6033, 10.1073/pnas.0401626101 Lunyak, 2002, Corepressor-dependent silencing of chromosomal regions encoding neuronal genes, Science, 298, 1747, 10.1126/science.1076469 Magavi, 2000, Induction of neurogenesis in the neocortex of adult mice, Nature, 405, 951, 10.1038/35016083 Martinowich, 2003, DNA-methylation-related chromatin remodeling in activity-dependent BDNF gene regulation, Science, 302, 890, 10.1126/science.1090842 Marusich, 1994, Hu neuronal proteins are expressed in proliferating neurogenic cells, J. Neurobiol., 25, 143, 10.1002/neu.480250206 Matarazzo, 2004, Temporal and regional differences in the olfactory proteome as a consequence of MeCP2 deficiency, Proc. Natl. Acad. Sci. U. S. A., 101, 7763, 10.1073/pnas.0307083101 McKay, 2000, Stem cells and the cellular organization of the brain, J. Neurosci. Res., 59, 298, 10.1002/(SICI)1097-4547(20000201)59:3<298::AID-JNR2>3.0.CO;2-U Miller, 2000, The prefrontal cortex and cognitive control, Nat. Rev., Neurosci., 1, 59, 10.1038/35036228 Mnatzakanian, 2004, A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome, Nat. Genet., 36, 339, 10.1038/ng1327 Moog, 2003, Neurodevelopmental disorders in males related to the gene causing Rett syndrome in females (MECP2), Eur. J. Paediatr. Neurol., 7, 5, 10.1016/S1090-3798(02)00134-4 Morest, 1966, Perfusion-fixation of the brain with chrome-osmium solutions for the rapid Golgi method, Am. J. Anat., 118, 811, 10.1002/aja.1001180309 Morshead, 2001, A new ‘spin’ on neural stem cells?, Curr. Opin. Neurobiol., 11, 59, 10.1016/S0959-4388(00)00174-4 Mullaney, 2004, Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain, Neuroscience, 123, 939, 10.1016/j.neuroscience.2003.11.025 Mullen, 1992, NeuN, a neuronal specific nuclear protein in vertebrates, Development, 116, 201, 10.1242/dev.116.1.201 Naidu, 2001, Neuroimaging studies in Rett syndrome, Brain Dev., 23, S62, 10.1016/S0387-7604(01)00381-3 Nan, 1997, MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin, Cell, 88, 471, 10.1016/S0092-8674(00)81887-5 Nan, 1998, Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex, Nature, 393, 386, 10.1038/30764 Planells-Cases, 2000, Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice, Biophys. J., 78, 2878, 10.1016/S0006-3495(00)76829-9 Reynolds, 1996, Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell, Dev. Biol., 175, 1, 10.1006/dbio.1996.0090 Reynolds, 1992, A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes, J. Neurosci., 12, 4565, 10.1523/JNEUROSCI.12-11-04565.1992 Shahbazian, 2002, Rett syndrome and MeCP2: linking epigenetics and neuronal function, Am. J. Hum. Genet., 71, 1259, 10.1086/345360 Shahbazian, 2002, Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3, Neuron, 35, 243, 10.1016/S0896-6273(02)00768-7 Shahbazian, 2002, Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation, Hum. Mol. Genet., 11, 115, 10.1093/hmg/11.2.115 Sholl, 1953, Dendritic organization in the neurons of the visual and motor cortices of the cat, J. Anat., 87, 387 Sommer, 1982, Cell that are O4 antigen-positive and O1 antigen-negative differentiate into O1 antigen-positive oligodendrocytes, Neurosci. Lett., 29, 183, 10.1016/0304-3940(82)90351-2 Spreafico, 1995, In situ labeling of apoptotic cell death in the cerebral cortex and thalamus of rats during development, J. Comp. Neurol., 363, 281, 10.1002/cne.903630209 Sprinkle, 1989, 2′,3′-Cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system, Crit. Rev. Neurobiol., 4, 235 Stancheva, 2003, A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by Notch in Xenopus embryos, Mol. Cell, 12, 425, 10.1016/S1097-2765(03)00276-4 Super, 1998, The functions of the preplate in development and evolution of the neocortex and hippocampus, Brain Res. Brain Res. Rev., 27, 40, 10.1016/S0165-0173(98)00005-8 Takizawa, 2001, DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain, Dev. Cell, 1, 749, 10.1016/S1534-5807(01)00101-0 Taupin, 2002, Adult neurogenesis and neural stem cells of the central nervous system in mammals, J. Neurosci. Res., 69, 745, 10.1002/jnr.10378 Tucker, 1990, The roles of microtubule-associated proteins in brain morphogenesis: a review, Brain Res. Brain Res. Rev., 15, 101, 10.1016/0165-0173(90)90013-E van der Kooy, 2000, Why stem cells?, Science, 287, 1439, 10.1126/science.287.5457.1439 Wallace, 1998, Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B, Nat. Genet., 19, 366, 10.1038/448 Xu, 2000, Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB, Neuron, 26, 233, 10.1016/S0896-6273(00)81153-8 Zhao, 2003, Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function, Proc. Natl. Acad. Sci. U. S. A., 100, 6777, 10.1073/pnas.1131928100