The role of C-reactive protein as a prognostic indicator in advanced cancer

Current Oncology Reports - Tập 4 - Trang 250-255 - 2002
Fade Aziz Mahmoud1, Nilo I. Rivera1
1Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, USA

Tóm tắt

C-reactive protein (CRP) is a nonspecific but sensitive marker of inflammation. Interleukin-6 (IL-6), IL-1, and tumor necrosis factor á induce the synthesis of CRP in hepatocytes. Increased CRP level is considered to be an important risk factor for atherosclerosis, myocardial infarction, peripheral vascular disease, and ischemic stroke. It is positively correlated with weight loss, anorexiacachexia syndrome, extent of disease, and recurrence in advanced cancer. Its role as a predictor of survival has been shown in multiple myeloma, melanoma, lymphoma, ovarian, renal, pancreatic, and gastrointestinal tumors. Measurement of CRP is simple, cheap, and routine and provides valuable information in palliative care.

Tài liệu tham khảo

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