Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma

Cancer Cell - Tập 32 Số 1 - Trang 101-114.e8 - 2017
Hien Dang1, Atsushi Takai1, Marshonna Forgues1, Yotsawat Pomyen1, Haiwei Mou2, Wen Xue3,2, Debashish Ray4, Kevin Ha5, Quaid Morris6,5,4, Timothy R. Hughes5,4, Xin Wei Wang1
1Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
2RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
3Program in Molecular Medicine, Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
4Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada
6Department of Computer Science, University of Toronto, Toronto, ON M5S 3E1, Canada

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Tài liệu tham khảo

Adelman, 2012, Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans, Nat. Rev. Genet., 13, 720, 10.1038/nrg3293

Auerbach, 2013, Relating genes to function: identifying enriched transcription factors using the ENCODE ChIP-Seq significance tool, Bioinformatics, 29, 1922, 10.1093/bioinformatics/btt316

Beer, 2004, Developmental context determines latency of MYC-induced tumorigenesis, PLoS Biol., 2, e332, 10.1371/journal.pbio.0020332

Boyault, 2007, Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets, Hepatology, 45, 42, 10.1002/hep.21467

Busa, 2007, The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells, Oncogene, 26, 4372, 10.1038/sj.onc.1210224

Castello, 2012, Insights into RNA biology from an atlas of mammalian mRNA-binding proteins, Cell, 149, 1393, 10.1016/j.cell.2012.04.031

Castello, 2013, RNA-binding proteins in Mendelian disease, Trends Genet., 29, 318, 10.1016/j.tig.2013.01.004

Chan, 2004, High-throughput tissue microarray analysis of c-myc activation in chronic liver diseases and hepatocellular carcinoma, Hum. Pathol., 35, 1324, 10.1016/j.humpath.2004.06.012

Chen, 2002, Gene expression patterns in human liver cancers, Mol. Biol. Cell, 13, 1929, 10.1091/mbc.02-02-0023

Chen, 2013, Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma, Nat. Med., 19, 209, 10.1038/nm.3043

Dang, 2012, MYC on the path to cancer, Cell, 149, 22, 10.1016/j.cell.2012.03.003

Delmore, 2011, BET bromodomain inhibition as a therapeutic strategy to target c-Myc, Cell, 146, 904, 10.1016/j.cell.2011.08.017

El-Serag, 2011, Hepatocellular carcinoma, N. Engl. J. Med., 365, 1118, 10.1056/NEJMra1001683

Gabay, 2014, MYC activation is a hallmark of cancer initiation and maintenance, Cold Spring Harb. Perspect. Med., 4, 10.1101/cshperspect.a014241

Gerstberger, 2014, A census of human RNA-binding proteins, Nat. Rev. Genet., 15, 829, 10.1038/nrg3813

Hahn, 2002, Rules for making human tumor cells, N. Engl. J. Med., 347, 1593, 10.1056/NEJMra021902

Han, 2013, RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3, J. Clin. Invest., 123, 2103, 10.1172/JCI61820

Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013

Iida, 2012, Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma, Oncol. Rep., 28, 728, 10.3892/or.2012.1821

Jiang, 2010, Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line, Int. J. Cancer, 127, 1011, 10.1002/ijc.25118

Kaposi-Novak, 2009, Central role of c-Myc during malignant conversion in human hepatocarcinogenesis, Cancer Res., 69, 2775, 10.1158/0008-5472.CAN-08-3357

Katz, 2012, Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation, Gastroenterology, 142, 1229, 10.1053/j.gastro.2012.02.009

Kechavarzi, 2014, Dissecting the expression landscape of RNA-binding proteins in human cancers, Genome Biol., 15, R14, 10.1186/gb-2014-15-1-r14

Kim, 2013, Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS, Nature, 495, 467, 10.1038/nature11922

Lee, 2004, Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling, Hepatology, 40, 667, 10.1002/hep.20375

Lee, 2006, A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells, Nat. Med., 12, 410, 10.1038/nm1377

Lowe, 2004, Intrinsic tumour suppression, Nature, 432, 307, 10.1038/nature03098

Lukong, 2008, RNA-binding proteins in human genetic disease, Trends Genet., 24, 416, 10.1016/j.tig.2008.05.004

Mittal, 2009, Dissecting the expression dynamics of RNA-binding proteins in posttranscriptional regulatory networks, Proc. Natl. Acad. Sci. USA, 106, 20300, 10.1073/pnas.0906940106

Nguyen, 2014, Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models, Cancer Cell, 26, 248, 10.1016/j.ccr.2014.06.018

Ortiz-Zapater, 2012, Key contribution of CPEB4-mediated translational control to cancer progression, Nat. Med., 18, 83, 10.1038/nm.2540

Rahl, 2010, c-Myc regulates transcriptional pause release, Cell, 141, 432, 10.1016/j.cell.2010.03.030

Ray, 2009, Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins, Nat. Biotechnol., 27, 667, 10.1038/nbt.1550

Ray, 2013, A compendium of RNA-binding motifs for decoding gene regulation, Nature, 499, 172, 10.1038/nature12311

Roessler, 2010, A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients, Cancer Res., 70, 10202, 10.1158/0008-5472.CAN-10-2607

Roessler, 2012, Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival, Gastroenterology, 142, 957, 10.1053/j.gastro.2011.12.039

Shachaf, 2004, MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer, Nature, 431, 1112, 10.1038/nature03043

Takai, 2016, Three-dimensional organotypic culture models of human hepatocellular carcinoma, Sci. Rep., 6, 21174, 10.1038/srep21174

Teufel, 2012, Snapshot liver transcriptome in hepatocellular carcinoma, J. Hepatol., 56, 990, 10.1016/j.jhep.2011.08.024

Theise, 2014

Thorgeirsson, 2002, Molecular pathogenesis of human hepatocellular carcinoma, Nat. Genet., 31, 339, 10.1038/ng0802-339

Vogelstein, 2013, Cancer genome landscapes, Science, 339, 1546, 10.1126/science.1235122

Wang, 2007, Improved low molecular weight Myc-Max inhibitors, Mol. Cancer Ther., 6, 2399, 10.1158/1535-7163.MCT-07-0005

Wang, 2012, MicroRNAs in liver disease, Gastroenterology, 142, 1431, 10.1053/j.gastro.2012.04.007

Wurth, 2012, Versatility of RNA-binding proteins in cancer, Comp. Funct. Genomics, 2012, 178525, 10.1155/2012/178525

Yin, 2003, Low molecular weight inhibitors of Myc-Max interaction and function, Oncogene, 22, 6151, 10.1038/sj.onc.1206641

Zhu, 2014, TCGA-assembler: open-source software for retrieving and processing TCGA data, Nat. Methods, 11, 599, 10.1038/nmeth.2956