A pneumonia outbreak associated with a new coronavirus of probable bat origin

Nature - Tập 579 Số 7798 - Trang 270-273 - 2020
Peng Zhou1, Xing‐Lou Yang1, Xian-Guang Wang2, Ben Hu1, Lei Zhang1, Wei Zhang1, Hao-Rui Si1, Yan Zhu1, Bei Li1, Chao-Lin Huang2, Huidong Chen2, Jing Chen1, Yun Luo1, Hua Guo1, Ren-Di Jiang1, Mei-Qin Liu1, Ying Chen1, Xu-Rui Shen1, Xi Wang1, Xiao-Shuang Zheng1, Kai Zhao1, Quan-Jiao Chen1, Fēi Dèng1, Linlin Liu3, Bing Yan1, Fa-Xian Zhan3, Yanyi Wang1, Geng Fu Xiao1, Zheng‐Li Shi1
1CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
2Wuhan Jin Yin-Tan Hospital, Wuhan, China
3Hubei Provincial Center for Disease Control and Prevention, Wuhan, China

Tóm tắt

AbstractSince the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5–7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of . In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.

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Nature

Tập 579 Số 7798

270-273

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