NDRG4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis

Adachi, 2004, Identification of SCN3B as a novel p53-inducible proapoptotic gene, Oncogene, 23, 7791, 10.1038/sj.onc.1208067 Chomova, 2016, Look into brain energy crisis and membrane pathophysiology in ischemia and reperfusion, Stress, 19, 341, 10.1080/10253890.2016.1174848 Cui, 2018, Protection of anthocyanin from Myrica rubra against cerebral ischemia-reperfusion injury via modulation of the TLR4/NF-κB and NLRP3 pathways, Molecules, 23, 10.3390/molecules23071788 Czabotar, 2014, Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy, Nat. Rev. Mol. Cell Biol., 15, 49, 10.1038/nrm3722 de Kloet, 2018, Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation, Front. Neuroendocrinol., 49, 124, 10.1016/j.yfrne.2018.02.003 Ding, 2012, NDRG4 is downregulated in glioblastoma and inhibits cell proliferation, OMICS, 16, 263, 10.1089/omi.2011.0146 Durukan, 2007, Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia, Pharmacol. Biochem. Behav., 87, 179, 10.1016/j.pbb.2007.04.015 Feigin, 2016, Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013, Lancet Neurol., 15, 913, 10.1016/S1474-4422(16)30073-4 Guan, 2000, Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer, Cancer Res., 60, 749 Guo, 2018, Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis, Exp. Cell Res., 368, 59, 10.1016/j.yexcr.2018.04.013 Jiang, 2017, AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging, Ageing Res. Rev., 38, 18, 10.1016/j.arr.2017.07.001 Jiang, 2018, Deciphering the roles of FOXO1 in human neoplasms, Int. J. Cancer, 23 Khoshnam, 2017, Pathogenic mechanisms following ischemic stroke, Neurol. Sci., 38, 1167, 10.1007/s10072-017-2938-1 Kitowska, 2010, N-myc downstream regulated  1 gene and its place in the cellular machinery, Acta Biochim. Pol., 57, 15, 10.18388/abp.2010_2367 Kotipatruni, 2012, NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas, Integr. Biol. (Camb), 4, 1185, 10.1039/c2ib20168b Kotipatruni, 2015, NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells, Oncotarget, 6, 17594, 10.18632/oncotarget.4009 Kovacevic, 2006, The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer, Carcinogenesis, 27, 2355, 10.1093/carcin/bgl146 Kuida, 2000, Caspase-9, Int. J. Biochem. Cell Biol., 32, 121, 10.1016/S1357-2725(99)00024-2 Laptenko, 2006, Transcriptional regulation by p53: one protein, many possibilities, Cell Death Differ., 13, 951, 10.1038/sj.cdd.4401916 Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 Liberale, 2018, Ischemic stroke across sexes: what is the status quo?, Front. Neuroendocrinol. Liu, 2008, N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis, Nucleic Acids Res., 36, 5335, 10.1093/nar/gkn504 Lv, 2018, PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders, Ageing Res. Rev., 44, 8, 10.1016/j.arr.2018.03.004 Melotte, 2009, N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer, J. Natl. Cancer Inst., 101, 916, 10.1093/jnci/djp131 Oda, 2000, A BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis, Science, 288, 1053, 10.1126/science.288.5468.1053 Okuda, 2008, Differential expression patterns of NDRG family proteins in the central nervous system, J. Histochem. Cytochem., 56, 175, 10.1369/jhc.7A7323.2007 Pavithra, 2018, Aromadendrene oxide 2, induces apoptosis in skin epidermoid cancer cells through ROS mediated mitochondrial pathway, Life Sci., 197, 19, 10.1016/j.lfs.2018.01.029 Perelman, 2012, JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry, Cell Death Dis., 3, e430, 10.1038/cddis.2012.171 Porter, 1999, Emerging roles of caspase-3 in apoptosis, Cell Death Differ., 6, 99, 10.1038/sj.cdd.4400476 Qu, 2002, Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family, Mol. Cell. Biochem., 229, 35, 10.1023/A:1017934810825 Qu, 2008, Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish, Dev. Biol. (Basel), 317, 486, 10.1016/j.ydbio.2008.02.044 Richardson, 2016, Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells, BMC Complement. Altern. Med., 16, 389, 10.1186/s12906-016-1368-6 Sasi, 2009, Regulated cell death pathways: new twists in modulation of BCL2 family function, Mol. Cancer Ther., 8, 1421, 10.1158/1535-7163.MCT-08-0895 Sax, 2002, BID regulation by p53 contributes to chemosensitivity, Nat. Cell Biol., 4, 842, 10.1038/ncb866 Schilling, 2009, NDRG4 is required for cell cycle progression and survival in glioblastoma cells, J. Biol. Chem., 284, 25160, 10.1074/jbc.M109.012484 Schmitt, 2002, Dissecting p53 tumor suppressor functions in vivo, Cancer Cell, 1, 289, 10.1016/S1535-6108(02)00047-8 Stein, 2004, NDRG1 is necessary for p53-dependent apoptosis, J. Biol. Chem., 279, 48930, 10.1074/jbc.M400386200 Sun, 2009, Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia, Nat. Neurosci., 12, 1300, 10.1038/nn.2395 Sun, 2013, NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury, Basic Res. Cardiol., 108, 341, 10.1007/s00395-013-0341-5 Sun, 2018, Ischemic postconditioning alleviates cerebral ischemia-reperfusion injury through activating autophagy during early reperfusion in rats, Neurochem. Res., 25 Takahashi, 2005, Expression of Ndrg2 in the rat frontal cortex after antidepressant and electroconvulsive treatment, Int. J. Neuropsychopharmacol., 8, 381, 10.1017/S1461145705005134 Wawryk-Gawda, 2014, P53 protein in proliferation, repair and apoptosis of cells, Protoplasma, 251, 525, 10.1007/s00709-013-0548-1 Xin, 2018, FOXO1/3: potential suppressors of fibrosis, Ageing Res. Rev., 41, 42, 10.1016/j.arr.2017.11.002 Xing, 2016, N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway, Basic Res. Cardiol., 111, 11, 10.1007/s00395-015-0519-0 Yamamoto, 2011, NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to  cerebral ischemia, J. Biol. Chem., 286, 26158, 10.1074/jbc.M111.256446 Yu, 2018, Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation, Biochim. Biophys. Acta, 1864, 563, 10.1016/j.bbadis.2017.11.023 Zhang, 2014, Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion, Proc. Natl. Acad. Sci. U. S. A., 111, 10684, 10.1073/pnas.1411026111 Zhao, 2001, Cloning and expression pattern of the human NDRG3 gene, Biochim. Biophys. Acta, 1519, 134, 10.1016/S0167-4781(01)00210-X Zhou, 2001, Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart, Genomics, 73, 86, 10.1006/geno.2000.6496