Liver function tests and their interpretation
Tóm tắt
Liver function tests (LFT) are a helpful screening tool, which are an effective modality to detect hepatic dysfunction. Since the liver performs a variety of functions so no single test is sufficient to provide complete estimate of function of liver. Often clinicians are faced with reports that do not tally with the clinical condition of the patient and they face difficulty in interpreting the LFT. An attempt is being made to study and understand the LFT and simplify their interpretation with algorithms.
Tài liệu tham khảo
Daniel SP, Marshall MK. Evaluation of the liver: laboratory tests. Schiff’s diseases of the liver, 8th edn. USA; JB Lippincott publications, 1999; 205–239.
Rosen HR, Keefe EB. Evaluation of abnormal liver enzymes, use of liver tests and the serology of viral hepatitis: Liver disease, diagnosis and management. 1st ed. New York; Churchill livingstone publishers, 2000; 24–35.
Sherlock S. Assessment of liver function Disease of liver and biliary system: Sheila Sherlock, 10th edn, London; Blackwell science ltd, 1997; 17–32.
Friedman SF, Martin P, Munoz JS. Laboratory evaluation of the patient with liver disease. Hepatology, a textbook of liver disease. Philedelphia; Saunders publication, 2003; 1: 661–709.
Rosalki SB, Mcintyre N. Biochemical investigations in the management of liver disease. Oxford textbook of clinical hepatology, 2nd ed. New York; Oxford university press, 1999; 503–521.
American Gastroenterological association. American gastroenterological association medical position statement: Evaluation of liver chemistry tests. Gastroenterology 2002; 123: 1364–1366.
Green RM, Flamm S. AGA technical review of evaluation of liver chemistry tests. Gastroenterology 2002; 123: 1367–1384.
Boyde TRC, Latner AL. Starch gel electrophoresis of transaminases in human tissues extracts and serum. Biochem J 1961; 82: 52–57.
Nalpus B, Vassault A, Charpin S et al. Serum mitochondrial aspartate amonitransferase as a marker of chronic alcoholism: diagnostic value and interpretation in a liver unit. Hepatology 1986; 6: 608–613.
Rej R. Measurement of aminotransferases, aspartate aminotransferases. CRC Crit Rev Clin Lab Sci 1985; 21: 99–103.
Dunn M et al the disappearance rate of glutamic oxaloacetic transaminase from the circulation and its distribution in the body’s fluid compartments and secretions. J Lab Clin Med 1958; 51; 259.
Frankl HD, Merrit JH. Enzyme activity in the serum and common bile duct. Am J Gastroenterol 1959; 31: 166–169.
Katkov WN, Friedman LS Cody H et al. Elevated serum alanine aminotransferases levels in blood donors; the contribution of hepatitis C virus. Ann Intern Med 1991; 115: 882–887.
Park GJH, Lin BPC, Ngu MC et al. Aspartate aminotransferases: alanine aminotransferases ratio in chronic hepatitis C infection: is it a predictor of cirrhosis? 2000; 15: 386–389.
Yasuda K, Okuda K, Endo N et al. Hypoaminotransferasemia in apatients undergoing long term hemodialysis: clinical and biochemical appraisal. Gastroenterology 1995; 109: 1295–1299.
Cohen GA, Goffinet JA, Donabedian RK et al. Observations on decreased serum glutamic oxaloacetic transaminase (SGOT) activity in azotemic patients. Ann Intern Med 1976; 84: 275–281.
Hagerstrand I: distribution of alkaline phosphatase activity in healthy and diseased human liver tissue. Acta Pathol Microbiol Scand 1975; 83: 519–524.
Gordon T. Factors associated with serum alkaline phosphatase level. Arch Pathol Lab Med 1993; 117: 187–193.
Reichling JJ, Kaplan MM. Clinical use of serum enzymes in liver disease. Dig Dis Sci 1988; 33: 1601–1614.
Kaplan MM. Serum alkaline phosphatase-another piece is added to the puzzle. Hepatology 1986; 6: 526–531.
Warnes TW, Hine P, Kay G. Intestinal alkaline phosphatase in the diagnosis of liver disease. Gut 1977; 18: 274–279.
Simko V. Alkaline phosphatases in biology and medicine. Dig Dis 1991; 9: 189–193.
Shaver WA, Bhatt H, Combes B. Low serum alkaline phosphatase activity in Wilson disease. Hepatology 1986; 6: 859–863.
Sallie R, Katsiyiannakis L, Baldwin D et al. Failure of simple biochemical indexes to reliably differenciate fulminant Wilson’s disease from other causes of fulminant liver failure. Hepatology 1992; 16: 1206–1211.
Jansen PLM, Muller M. The molecular genetics of familial intrahepatic cholestasis 2000; 47: 1–5.
Forman WB, Barnhart MI. Cellular site for fibinogen synthesis. JAMA 1964; 187: 168–174.
Mizuno A, Uematsu T, Gotoh S et al. The measurement of caffeine concentration in scalp hair as an indicator of liver Disease 1996; 48: 660–665.
Anderson GF, Barnhart MI. intracellular localization of prothrombin. Proc Soc Exp Biol Med 1964; 116: 1–4.
Jefferson DM et al. Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes. Hepatology 1985; 5: 14–19.
Rothschild MA et al. Albumin synthesis in cirrhotic subjects studied with carbonate 14 C. J Clin Invest 1969; 48: 344–349.
Hasch E at al. Albumin synthesis rate as a measure of liver function in patients with cirrhosis. Arch Intern Med 1967; 182: 38–44.