Impact of ambient air pollution and wheeze-associated disorders in children in Southeast Asia: a systematic review and meta-analysis

Reviews on Environmental Health - Tập 34 Số 2 - Trang 125-139 - 2019
Ly M.T. Luong1,2,3, Peter D. Sly1,3, Phong K. Thai4, Dung Phung5
1Children’s Health and Environment Program , The University of Queensland , Brisbane, Queensland , Australia
2Faculty of Environmental Sciences, VNU University of Science, Hanoi, Vietnam
3Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia
4Queensland Alliance for Environmental Health Science (QAEHS) , The University of Queensland , Brisbane, Queensland , Australia
5Centre for Environment and Population Health, School of Medicine , Griffith University , Gold Coast, Queensland , Australia

Tóm tắt

Abstract Several systematic reviews have been conducted so far to examine the effect of air pollution on respiratory diseases, but there has not been a corresponding meta-analysis to estimate the effect sizes for wheeze-associated diseases/disorders, which is one of the leading causes of emergency department visits and hospitalizations for children worldwide. The aim of this review is to systematically evaluate the relationship between air pollution and risk of wheeze-associated disorders in children in Southeast Asia. We searched the relevant computerized databases (PubMed, EMBASE, Web of Science, Scopus and Cochrane library) for indexed publications up to July 2018. Finally, eight studies were qualified for performing a random-effect meta-analysis to compute the pooled effect sizes. The results show that each increase of 10 μg/m3 in concentrations of PM2.5, PM1 was associated with 1–2% increase in risk of wheeze-associated disorders. Positive associations were found for PM10, SO2, NO2, NOx but no association was found for CO and O3. We confirmed the strong effect of fine particulate matters on respiratory health and recommend an updated meta-analysis should be done when more studies are available.

Từ khóa


Tài liệu tham khảo

WHO. Air pollution levels rising in many of the world’s poorest cities; 2016 [cited 2018/29/09]. Available from: http://www.who.int/en/news-room/detail/12-05-2016-air-pollution-levels-rising-in-many-of-the-world-s-poorest-cities.

AQICN. World Health Organization: 2014 Air Pollution Ranking; 2015 [cited 2018/29/09]. Available from: http://aqicn.org/faq/2015-05-16/world-health-organization-2014-air-pollution-ranking/.

World Health Organization. WHO Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide – Global update 2005 – Summary of risk assessment. Geneva: WHO; 2006.

WHO. WHO Global Urban Ambient Air Pollution Database (update 2016); 2016 [cited 2018/29/09]. Available from: http://www.who.int/phe/health_topics/outdoorair/databases/cities/en/.

MONRE. National State of Environment Report 2013 on Air quality. Vietnam Environment Administration; 2014.

WHO. Ambient (outdoor) air pollution database 2016; 2016 [cited 2018/29/09]. Available from: http://www.who.int/phe/health_topics/outdoorair/databases/who-aap-database-may2016.xlsx?ua=1.

Langkulsen U, Jinsart W, Karita K, Yano E. Respiratory symptoms and lung function in Bangkok school children. Eur J Public Health 2006;16(6):676–81.

Hong CY, Chia SE, Widjaja D, Saw SM, Lee J, Munoz C, et al. Prevalence of respiratory symptoms in children and air quality by village in rural Indonesia. J Occup Environ Med 2004;46(11):1174–9.

Chew F, Goh D, Ooi B, Saharom R, Hui J, Lee B. Association of ambient air-pollution levels with acute asthma exacerbation among children in Singapore. Allergy 1999;54(4):320–9.

Ritz B, Wilhelm M, Zhao Y. Air pollution and infant death in southern California, 1989–2000. Pediatrics 2006;118(2):493–502.

Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? Am J Epidemiol 2007;166(8):880–8.

Ye Y, Zulu E, Mutisya M, Orindi B, Emina J, Kyobutungi C. Seasonal pattern of pneumonia mortality among under-five children in Nairobi’s informal settlements. Am J Trop Med Hyg 2009;81(5):770–5.

Delfino RJ, Staimer N, Gillen D, Tjoa T, Sioutas C, Fung K, et al. Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environ Health Perspect 2006;114:1736–43.

Andersen ZJ, Wahlin P, Raaschou-Nielsen O, Scheike T, Loft S. Ambient particle source apportionment and daily hospital admissions among children and elderly in Copenhagen. J Expo Sci Environ Epidemiol 2007;17(7):625–36.

Weinmayr G, Romeo E, De Sario M, Weiland SK, Forastiere F. Short-term effects of PM10 and NO2 on respiratory health among children with asthma or asthma-like symptoms: a systematic review and meta-analysis. Environ Health Perspect 2010;118(4):449.

Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med 2002;166(8):1092–8.

Le TG, Ngo L, Mehta S, Do V, Thach T, Vu X, et al. Effects of short-term exposure to air pollution on hospital admissions of young children for acute lower respiratory infections in Ho Chi Minh City, Vietnam. Res Rep Health Eff Inst 2012(169):5–72; discussion 3–83.

Lin W, Huang W, Zhu T, Hu M, Brunekreef B, Zhang Y, et al. Acute respiratory inflammation in children and black carbon in ambient air before and during the 2008 Beijing Olympics. Environ Health Perspect 2011;119(10):1507.

O’Connor GT, Neas L, Vaughn B, Kattan M, Mitchell H, Crain EF, et al. Acute respiratory health effects of air pollution on children with asthma in US inner cities. J Allergy Clin Immunol 2008;121(5):1133–9.e1.

Ostro B, Roth L, Malig B, Marty M. The effects of fine particle components on respiratory hospital admissions in children. Environ Health Perspect 2009;117(3):475.

Karr C, Lumley T, Schreuder A, Davis R, Larson T, Ritz B, et al. Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitis. Am J Epidemiol 2007;165(5):553–60.

Karr C, Lumley T, Shepherd K, Davis R, Larson T, Ritz B, et al. A case-crossover study of wintertime ambient air pollution and infant bronchiolitis. Environ Health Perspect 2006;114:277–81.

Sram RJ, Binkova B, Dostal M, Merkerova-Dostalova M, Libalova H, Milcova A, et al. Health impact of air pollution to children. Int J Hyg Environ Health 2013;216(5):533–40.

Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, et al. Air pollution exposure and lung function in children: the ESCAPE project. Environ Health Perspect (Online) 2013;121(11–12):1357.

Götschi T, Heinrich J, Sunyer J, Künzli N. Long-term effects of ambient air pollution on lung function: a review. Epidemiology 2008;19(5):690–701.

Health Effects Institute. Outdoor air pollution and health in the developing countries of Asia: a comprehensive review. Special report 18, HEI International Scientific Oversight Committee, 2010.

Nhung NTT, Amini H, Schindler C, Kutlar Joss M, Dien TM, Probst-Hensch N, et al. Short-term association between ambient air pollution and pneumonia in children: a systematic review and meta-analysis of time-series and case-crossover studies. Environ Pollut 2017;230:1000–8.

Mehta S, Shin H, Burnett R, North T, Cohen AJ. Ambient particulate air pollution and acute lower respiratory infections: a systematic review and implications for estimating the global burden of disease. Air Qual Atmos Health 2013;6(1):69–83.

World Health Organozation. Pneumonia – Fact sheet No331: World Health Organization; 2015. Available from: http://www.who.int/mediacentre/factsheets/fs331/en/.

World Health Organozation. Asthma – Fact sheet No307: World Health Organization; 2013 [updated 11/2013]. Available from: http://www.who.int/mediacentre/factsheets/fs307/en/.

GINA. Global strategy for asthma management and prevention. Global Intiative for Asthma, 2014. Available from: https://ginasthma.org/.

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. J Am Med Assoc 2000;283(15):2008–12.

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151(4):264–9.

Phung D, Thai PK, Guo Y, Morawska L, Rutherford S, Chu C. Ambient temperature and risk of cardiovascular hospitalization: an updated systematic review and meta-analysis. Sci Total Environ 2016;550:1084–102.

Berman NG, Parker RA. Meta-analysis: neither quick nor easy. BMC Med Res Methodol 2002;2(1):10.

Shah ASV, Lee KK, McAllister DA, Hunter A, Nair H, Whiteley W, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis. Br Med J 2016;354:i4851.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J 2003;327(7414):557.

Borenstein M, Hedges LV, Higgins JP, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods 2010;1(2):97–111.

Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997;315(7109):629–34.

Rothstein H, Sutton A, Borenstein M. Publication Bias in Meta-Analysis. Publication Bias in Meta-Analysis-Prevention, Assessment and Adjustment. Chichester: John Wiley & Sons; 2005.

Vichit-Vadakan N, Ostro BD, Chestnut LG, Mills DM, Aekplakorn W, Wangwongwatana S, et al. Air pollution and respiratory symptoms: results from three panel studies in Bangkok, Thailand. Environ Health Perspect 2001;109(Suppl 3):381.

Vichit-Vadakan N, Vajanapoom N, Ostro B. The Public Health and Air Pollution in Asia (PAPA) Project: estimating the mortality effects of particulate matter in Bangkok, Thailand. Environ Health Perspect 2008;116(9):1179.

Aekplakorn W, Loomis D, Vichit-Vadakan N, Shy C, Plungchuchon S. Acute effects of SO2 and particles from a power plant on respiratory symptoms of children, Thailand. Southeast Asian J Trop Med Public Health 2003;34(4):906–14.

Mehta S, Ngo LH, Van Dzung D, Cohen A, Thach TQ, Dan VX, et al. Air pollution and admissions for acute lower respiratory infections in young children of Ho Chi Minh City. Air Qual Atmos Health 2013;6(1):167–79.

Ly M. T. Luong, Dung Phung, Tran Ngoc Dang, Peter D. Sly, Lidia Morawska, Thai PK. Seasonal association between ambient ozone and hospital admission for respiratory diseases in Hanoi, Vietnam. PloS One 2018;13(9):e0203751.

Nhung NTT, Schindler C, Dien TM, Probst-Hensch N, Perez L, Künzli N. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: an eight-year time series study. Environ Int 2018;110:139–48.

Rahman SRA, Ismail SS, Sahani M, Ramli MF, Latif MT. A case crossover analysis of primary air pollutants association on acute respiratory infection (ARI) among children in urban region of Klang valley, Malaysia. Ann Trop Med Parasitol 2017;10(1):44.

Sterne JAC, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 2000;53(11):1119–29.

USEPA. Final Report: Integrated Science Assessment for Particulate Matter. Washington, DC: U.S. Environmental Protection Agency, EPA/600/R-08/139F; 2009 12/2008.

World Health Organization. WHO Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide 2005. Available from: http://apps.who.int/iris/bitstream/10665/69477/1/WHO_SDE_PHE_OEH_06.02_eng.pdf.

Fuertes E, MacIntyre E, Agius R, Beelen R, Brunekreef B, Bucci S, et al. Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects. Int J Hyg Environ Health 2014;217(8):819–29.

Luong LM, Phung D, Sly PD, Morawska L, Thai PK. The association between particulate air pollution and respiratory admissions among young children in Hanoi, Vietnam. Sci Total Environ 2017;578:249–55.

Halonen JI, Lanki T, Yli-Tuomi T, Kulmala M, Tiittanen P, Pekkanen J. Urban air pollution, and asthma and COPD hospital emergency room visits. Thorax 2008;63(7):635–41.

Kesavachandran C, Pangtey BS, Bihari V, Fareed M, Pathak MK, Srivastava AK, et al. Particulate matter concentration in ambient air and its effects on lung functions among residents in the National Capital Region, India. Environ Monit Assess 2013;185(2):1265–72.

Churg A, Brauer M, del Carmen Avila-Casado M, Fortoul TI, Wright JL. Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 2003;111(5):714.

Nhung NTT, Schindler C, Dien TM, Probst-Hensch N, Perez L, Künzli N. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: an eight-year time series study. Environ Int 2018;110(Suppl C):139–48.

EPA. Integrated Science Assessment for Sulfur Oxides – Health Criteria; 2017. Available from: https://cfpub.epa.gov/ncea/isa/recordisplay.cfm?deid=338596.

World Health Organization. Ambient (outdoor) air quality and health: World Health Organization; 2005. Available from: http://www.who.int/mediacentre/factsheets/fs313/en/.

EPA. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria; 2016. Available from: https://cfpub.epa.gov/ncea/isa/recordisplay.cfm?

ATSDR. Agency for Toxic Substances and Disease Registry. ToxFAQs for nitrogen oxides. 2002. Available from: www.atsdr.cdc.gov/toxfaqs/tf.asp?id=396&tid=69.

USEPA. Final report: Integrated Science Assessment (ISA) for Sulfur Dioxide – Health Criteria. Washington, DC: U.S. Environmental Protection Agency, EPA/600/R-08/047F; 2008 07/2008.

Pikhart H, Bobak M, Kriz B, Danova J, Celko MA, Prikazsky V, et al. Outdoor air concentrations of nitrogen dioxide and sulfur dioxide and prevalence of wheezing in school children. Epidemiology 2000;11(2):153–60.

Pershagen G, Rylander E, Norberg S, Eriksson M, Nordvall SL. Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children. Int J Epidemiol 1995;24(6):1147–53.

Lin S, Liu X, Le LH, Hwang S-A. Chronic exposure to ambient ozone and asthma hospital admissions among children. Environ Health Perspect 2008;116(12):1725.

Yang Q, Chen Y, Shi Y, Burnett RT, McGrail KM, Krewski D. Association between ozone and respiratory admissions among children and the elderly in Vancouver, Canada. Inhal Toxicol 2003;15(13):1297–308.

Ghaffari HR, Aval HE, Alahabadi A, Mokammel A, Khamirchi R, Yousefzadeh S, et al. Asthma disease as cause of admission to hospitals due to exposure to ambient oxidants in Mashhad, Iran. Environ Sci Pollut Res 2017;24(35):27402–8.

Zhang S, Li G, Tian L, Guo Q, Pan X. Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: a systematic review and meta-analysis. Environ Res 2016;148:15–23.

Evans KA, Halterman JS, Hopke PK, Fagnano M, Rich DQ. Increased ultrafine particles and carbon monoxide concentrations are associated with asthma exacerbation among urban children. Environ Res 2014;129:11–9.

Tian L, Qiu H, Pun VC, Lin H, Ge E, Chan JC, et al. Ambient carbon monoxide associated with reduced risk of hospital admissions for respiratory tract infections. Am J Respir Crit Care Med 2013;188(10):1240–5.

U.S. Environmental Protection Agency. Quantitative Risk and Exposure Assessment for Carbon Monoxide – Amended Carbon Monoxide (CO) Standards – Risk and Exposure Assessments from Current Review. North Carolina: Research Triangle Park; 2010.

Fusco D, Forastiere F, Michelozzi P, Spadea T, Ostro B, Arca M, et al. Air pollution and hospital admissions for respiratory conditions in Rome, Italy. Eur Respir J 2001;17(6):1143–50.

Schwartz J. Air pollution and hospital admissions for the elderly in Detroit, Michigan. Am J Respir Crit Care Med 1994;150(3):648–55.

World Health Organization. 7 million premature deaths annually linked to air pollution: World Health Organization; 2014. Available from: http://www.who.int/mediacentre/news/releases/2014/air-pollution/en/.

Cohen AJ, Ross Anderson H, Ostro B, Pandey KD, Krzyzanowski M, Künzli N, et al. The global burden of disease due to outdoor air pollution. J Toxicol Environ Health 2005;68(13–14):1301–7.

Nguyen T, Tran T, Roberts C, Fox G, Graham S, Marais B. Risk factors for child pneumonia-focus on the Western Pacific Region. Paediatr Respir Rev 2017;21:95–101.